62732-44-9

• 常用中文名：2,3,5,6,7,8-六氢-1H-环戊并[b]喹啉-9-胺
• 常用英文名：Ipidacrine
• CAS号：62732-44-9
• 分子式：C₁₂H₁₆N₂
• 分子量：188.26900
• 相关类别： 信号通路 神经信号通路 疼痛
• 发布时间：2018-12-23 09:39:42
• 更新时间：2024-01-02 11:01:52
• 2,3,5,6,7,8-六氢-1H-环戊烷[b]喹啉-9-胺是一种药物活性化合物,是一种促智剂,用作胆碱酯酶抑制剂,用于治疗阿尔茨海默病[1]。

名称

• 中文名: 2,3,5,6,7,8-六氢-1H-环戊并[b]喹啉-9-胺
• 英文名: 2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinolin-9-amine
• 英文别名: Amiridine; Ipidacrine; 9-amino-2,3,5,6,7,8-hexahydro-1-cyclopenta<b>quinoline; Amiridin

物化性质

• 密度: 1.17 g/cm3
• 沸点: 367.969ºC at 760 mmHg
• 分子式: C₁₂H₁₆N₂
• 分子量: 188.26900
• 闪点: 203.991ºC
• 精确质量: 188.13100
• PSA: 38.91000
• LogP: 2.61250
• 折射率: 1.634
• 储存条件: 2-8°C，密封，干燥

生物活性

• 描述: 2,3,5,6,7,8-六氢-1H-环戊烷[b]喹啉-9-胺是一种药物活性化合物,是一种促智剂,用作胆碱酯酶抑制剂,用于治疗阿尔茨海默病[1]。
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> 神经信号通路 >> 疼痛
• 参考文献:

  [1]. A.Dubika, K. Veldre, et al. Phase Transitions of Ipidacrine Hydrochloride Polymorphs and Hydrates. The Open Conference Proceedings Journal, 2011, 2, 21-27.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : GY5897400 CHEMICAL NAME : 1H-Cyclopenta(b)quinolin-9-amine, 2,3,5,6,7,8-hexahydro- CAS REGISTRY NUMBER : 62732-44-9 BEILSTEIN REFERENCE NO. : 0475930 LAST UPDATED : 199612 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C12-H16-N2 MOLECULAR WEIGHT : 188.30 WISWESSER LINE NOTATION : TC566 BNT&TJ HZ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 39 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - miosis (pupillary constriction) Behavioral - tremor Gastrointestinal - hypermotility, diarrhea REFERENCE : PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 11,184,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 52 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 23,709,1989

安全

• 危害码 (欧洲): Xi

合成路线

58996-10-4 ~76% 62732-44-9

文献：Upadysheva, A. V.; Grigor'eva, N. D.; Ryabokobylko, Yu. S.; Znamenskaya, A. P. Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983 , p. 95 - 99 Khimiya Geterotsiklicheskikh Soedinenii, 1983 , vol. 19, # 1 p. 107 - 111

108-94-1 2941-23-3 ~% 62732-44-9

文献：Pharmaceutical Chemistry Journal, , vol. 26, # 9-10 p. 769 - 772 Khimiko-Farmatsevticheskii Zhurnal, , vol. 26, # 9-10 p. 83 - 85

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