5575-21-3

• 常用中文名：头孢洛宁
• 常用英文名：Cephalonium
• CAS号：5575-21-3
• 分子式：C₂₀H₁₈N₄O₅S₂
• 分子量：458.51
• 相关类别： 原料药 抗生素类药物 头孢菌素类药
• 发布时间：2018-06-22 16:12:22
• 更新时间：2024-01-02 20:08:05
• 头孢洛尼是第一代β-内酰胺头孢菌素类抗生素,广泛用于研究包括葡萄球菌在内的革兰氏阳性菌引起的乳腺炎[1][2][3]。

名称

• 中文名: 头孢洛宁 水合物
• 英文名: (6R,7R)-3-[(4-carbamoylpyridin-1-ium-1-yl)methyl]-8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• 中文别名: 头孢洛宁
• 英文别名: Cephalonium; Cefalonum; Cefalonio [INN-Spanish]; Cefalonium [INN-Latin]; Cefalonium Hydrate; CEFALONIUM; EINECS 226-948-7

物化性质

• 熔点: 147-150° (dec)
• 分子式: C₂₀H₁₈N₄O₅S₂
• 分子量: 458.51
• 精确质量: 458.07200
• PSA: 190.05000
• 储存条件: 2-8°C

生物活性

• 描述: 头孢洛尼是第一代β-内酰胺头孢菌素类抗生素,广泛用于研究包括葡萄球菌在内的革兰氏阳性菌引起的乳腺炎[1][2][3]。
• 相关类别:
  研究领域 >> 感染
  研究领域 >> 炎症/免疫
  信号通路 >> 抗感染 >> 细菌
• 靶点:

  β-lactam

• 参考文献:

  [1]. Harada K, et, al. Assessment of the Usefulness of Cefapirin and Cefalonium Disks for Susceptibility Testing of Staphylococcus aureus Isolates from Bovine Mastitis. Antibiotics (Basel). 2020 Apr 21;9(4):197.

  [2]. Demon D, et, al. The intramammary efficacy of first generation cephalosporins against Staphylococcus aureus mastitis in mice. Vet Microbiol. 2012 Nov 9;160(1-2):141-50.

  [3]. Berry EA, et, al. Effect of an intramammary teat seal and dry cow antibiotic in relation to dry period length on postpartum mastitis. J Dairy Sci. 2007 Feb;90(2):760-5.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UU2800000 CHEMICAL NAME : Pyridinium, 4-carbamoyl-1-((2-carboxy-8-oxo-7-(2-(2-thienyl)aceta mido)-5-thia-1-aza- bicyclo(4.2.0)oct-2-en-3-yl)methyl)- hydroxide, inner salt CAS REGISTRY NUMBER : 5575-21-3 LAST UPDATED : 199712 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C20-H18-N4-O5-S2 MOLECULAR WEIGHT : 458.54 WISWESSER LINE NOTATION : T46 ANV ES GUTJ HVQ CMV1- BT5SJ& G1- AT6KJ DVZ &Q HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2750 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971

安全

• 危害码 (欧洲): Xn