528851-31-2

• 常用中文名：盐酸环丙沙星杂质C
• 常用英文名：desethylene ciprofloxacin, hydrochloride
• CAS号：528851-31-2
• 分子式：C₁₅H₁₇ClFN₃O₃
• 分子量：341.77
• 相关类别： 分析化学 标准品 药典标准品和杂志标准品
• 发布时间：2016-11-29 06:39:28
• 更新时间：2026-07-27 18:32:06
• Desethylene Ciprofloxacin hydrochloride 是环丙沙星 (Ciprofloxacin (HY-B0356)) 的主要代谢物。环丙沙星是一种具有口服活性拓扑异构酶 IV 抑制剂。Desethylene Ciprofloxacin hydrochloride 具有抗菌活性。

名称

• 中文名: 盐酸环丙沙星杂质C
• 英文名: 7-(2-aminoethylamino)-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid,hydrochloride
• 中文别名: 盐酸环丙沙星杂质Ⅲ杂质C7-[(2-氨乙基)氨基]-1-环丙基-6-氟-4-氧代-1,4-二氢喹啉-3-羧酸; 环丙沙星杂质3(环丙沙星杂质C); 盐酸环丙沙星杂质C盐酸盐; 环丙沙星杂质C 盐酸盐; 环丙沙星杂质C; 环丙沙星乙二胺类似物标准品; 环丙沙星乙二胺类似物; 7-((2-氨基乙基)氨基)-1-环丙基-6-氟-4-氧代-1,4-二氢喹啉-3-羧酸 盐酸盐; 脱乙烯环丙沙星盐酸盐; 环丙沙星杂质C HCL; 环丙沙星杂质C(恩诺沙星杂质G); 环丙沙星杂质3、盐酸脱乙烯环丙沙星(对照品); 环丙沙星杂质Ⅲ(环丙沙星杂质 C) 7-[(2-氨乙基)氨基]-1-环丙基-6-氟-4-氧代-1,4-二氢喹啉-3-羧酸; 去乙烯环丙沙星 盐酸盐; 去乙烯基环丙沙星盐酸盐; 环丙沙星杂质C盐酸盐(恩诺沙星杂质G盐酸盐); 去乙基烯环丙沙星,盐酸盐; 环丙沙星杂质Ⅲ（环丙沙星杂质 C） 7-[(2-氨乙基)氨基]-1-环丙基-6-氟-4-氧代-1，4-二氢喹啉-3-羧酸; 环丙沙星杂质3; 去乙基烯环丙沙星，盐酸盐
• 英文别名: Ciprofloxacin Impurity C HCl/Desethylene Ciprofloxacin HCl; 7-[(2-Aminoethyl)amino]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecboxylic Acid; BAY-r 3964,M1-Ciprofloxacin,7-[(2-Aminoethyl)amino]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid; 7-[(2-Aminoethyl)amino]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-cboxylic Acid Hydrochl; 7-[(2-Aminoethyl)amino]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecboxylic acid hydrochloride; Enrofloxacin IMp. G , HCl; Ciprofloxacin Hydrochloride Impurity Ⅲ:Ciprofloxacin Impurity C; Labetalol Impurity C HCl; 7-((2-aminoethyl)amino)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-cboxylic acid hydrochloride; Ciprofloxacin ImpuritⅢ:(Ciprofloxacin Impurity C) 7-[(2-Aminoethyl)amino]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecboxylic Acid; Enrofloxacin Impurity-G /Ciprofloxacin Impurity-C (Ciprofloxacin ethylenediamine compound)-HCL SALT; Ciprofloxacin Impurity-C / Enrofloxacin Impurity-G (Ciprofloxacin ethylenediamine compound)-HCL SALT; Fluoroquinolonic acid C; Ciprofloxacin Impurity C HCl(Enrofloxacin Impurity G HCl); DESETHYLENE CIPROFLOXACIN, HYDROCHLORIDE; BAY-r3964,M1-Ciprofloxacin,7-[(2-Aminoethyl)amino]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecboxylicAci; Ciprofloxacin Impurity 3(Ciprofloxacin Impurity C); 7-((2-aminoethyl)amino)-6-chloro-1-cyclopropyl-4-oxo-1,4-dihydroquinoline-3-cboxylic acid hydrochloride; BAY-r 3964, M1-Ciprofloxacin, 7-[(2-Aminoethyl)amino]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecboxylic Acid; 7-[(2-Aminoethyl)amino]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-cboxylic Acid Hydrochloride (Ethylenediamine Compound Hydrochloride); Ciprofloxacin IMpurity C HCl; Desethylene Ciprofloxacin,Hydrochloride; Ciprofloxacin Hydrochloride Impurity C as Hydrochloride; 7-(2-aminoethylamino)-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-cboxylic acid,hydrochloride; Enrofloxacin Imp. G (EP),HCl; Ciprofloxacin Ethylene Diamine; Ciprofloxacin IMpurity C; 7-[(2-amino-ethyl)amino]-1-cyclopropyl-1,4-dihydro-6-fluoro-4-oxo-quinoline-3-carboxylic acid hydrochloride; Ciprofloxacin Ethylenediamine Analog

物化性质

• 熔点: >240ºC dec.
• 分子式: C₁₅H₁₇ClFN₃O₃
• 分子量: 341.77
• 精确质量: 341.09400
• PSA: 97.35000
• LogP: 3.11960
• 储存条件: -20°C Freezer, Under Inert Atmosphere

生物活性

• 描述: Desethylene Ciprofloxacin hydrochloride 是环丙沙星 (Ciprofloxacin (HY-B0356)) 的主要代谢物。环丙沙星是一种具有口服活性拓扑异构酶 IV 抑制剂。Desethylene Ciprofloxacin hydrochloride 具有抗菌活性。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Šíma M, et al. Factors Affecting the Metabolic Conversion of Ciprofloxacin and Exposure to Its Main Active Metabolites in Critically Ill Patients: Population Pharmacokinetic Analysis of Desethylene Ciprofloxacin. Pharmaceutics. 2022 Aug 4;14(8):1627.

安全

• 符号: GHS06, GHS09
• 信号词: Danger
• 危害声明: H301-H410
• 警示性声明: P273-P301 + P310-P501
• 危害码 (欧洲): T,N
• 风险声明 (欧洲): 25-50/53
• 安全声明 (欧洲): 45-60-61
• 危险品运输编码: UN 2811 6.1 / PGIII

合成路线

86393-33-1 107-15-3 ~% 528851-30-1 528851-31-2

文献：WO2004/101590 A1, ; Page 32-33 ;

上下游产品

上游产品  2
86393-33-1 107-15-3
下游产品  0