11006-33-0

• 常用中文名：腐草霉素
• 常用英文名：Phleomycin
• CAS号：11006-33-0
• 分子式：C₅₂H₇₅N₁₆O₂₁S₂
• 分子量：1324.38000
• 相关类别： 原料药 人工合成抗感染类药 抗真菌类药
• 发布时间：2018-03-10 08:00:00
• 更新时间：2024-01-15 06:19:26
• Phleomycin 是在链霉菌中发现的广谱糖肽类抗生素 (antibiotic) 源于链霉菌。与博莱霉素类似,它是一种有效的 DNA 裂解剂,与 DNA 结合并插入,破坏双螺旋结构的完整性。与博莱霉素 (HY-17565A) 类似,它是一种有效的 DNA 裂解剂,与 DNA 结合并插入,破坏双螺旋结构的完整性。

名称

• 中文名: 腐草霉素
• 英文名: phleomycin from strepomyces verticillus
• 英文别名: PHLEOMYCIN; MFCD00131846; phleomycincomplex; PHLEOMYCIN (STREPTOMYCES VERTICILLUS); phleomycin from streptomyces*verticillus; ZEOCIN(TM)

物化性质

• 密度: 1.83 g/cm3
• 沸点: 1718.8ºC at 760 mmHg
• 分子式: C₅₂H₇₅N₁₆O₂₁S₂
• 分子量: 1324.38000
• 闪点: 993.3ºC
• 精确质量: 1323.47000
• PSA: 664.89000
• 外观性状: light blue
• 蒸汽压: 0mmHg at 25°C
• 折射率: 1.777
• 储存条件:

  密封于2-8°C阴凉干燥处。

• 稳定性:

  遵照规格使用和储存则不会分解。

• 水溶解性: H2O: 10 mg/mL, clear, blue
• 分子结构:

  1、摩尔折射率：无可用

  2、 摩尔体积（cm³/mol）： 无可用

  3、 等张比容（90.2K）：无可用

  4、 表面张力（dyne/cm）：无可用

• 计算化学:

  1、 疏水参数计算参考值（XlogP）：-10.2

  2、 氢键供体数量：20

  3、 氢键受体数量：29

  4、 可旋转化学键数量：0

  5、 拓扑分子极性表面积（TPSA）：648

  6、 重原子数量：91

  7、 表面电荷：0

  8、 复杂度：2650

  9、 同位素原子数量：0

  10、 确定原子立构中心数量：9

  11、 不确定原子立构中心数量：10

  12、 确定化学键立构中心数量：0

  13、 不确定化学键立构中心数量：0

  14、 共价键单元数量：1

• 更多:

  1. 性状：无可用

  2. 密度（g/mL,25/4℃）： 无可用

  3. 相对蒸汽密度（g/mL,空气=1）：无可用

  4. 熔点（ºC）：无可用

  5. 沸点（ºC,常压）：无可用

  6. 沸点（ºC,5.2kPa）： 无可用

  7. 折射率： 无可用

  8. 闪点（ºC）： 无可用

  9. 比旋光度（º）：无可用

  10. 自燃点或引燃温度（ºC）：无可用

  11. 蒸气压（kPa,25ºC）：无可用

  12. 饱和蒸气压（kPa,60ºC）：无可用

  13. 燃烧热（KJ/mol）：无可用

  14. 临界温度（ºC）：无可用

  15. 临界压力（KPa）：无可用

  16. 油水（辛醇/水）分配系数的对数值：无可用

  17. 爆炸上限（%,V/V）：无可用

  18. 爆炸下限（%,V/V）： 无可用

  19. 溶解性：溶于水，蓝色澄清溶液

生物活性

• 描述: Phleomycin 是在链霉菌中发现的广谱糖肽类抗生素 (antibiotic) 源于链霉菌。与博莱霉素类似,它是一种有效的 DNA 裂解剂,与 DNA 结合并插入,破坏双螺旋结构的完整性。与博莱霉素 (HY-17565A) 类似,它是一种有效的 DNA 裂解剂,与 DNA 结合并插入,破坏双螺旋结构的完整性。
• 相关类别:
  研究领域 >> 癌症
  研究领域 >> 感染
  信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成
  信号通路 >> 抗感染 >> 细菌
• 靶点:

  IC50: Antibiotic[1]

• 参考文献:

  [1]. Kamila Stokowa-Sołtys, et al. Phleomycin complex - Coordination mode and in vitro cleavage of DNA. J Inorg Biochem. 2019 Jun;195:71-82.

MSDS

Name: Zeocin Material Safety Data Sheet Synonym: Phleomycin CAS: 11006-33-0 Section 1 - Chemical Product MSDS Name:Zeocin Material Safety Data Sheet Synonym:Phleomycin Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 11006-33-0 Zeocin 100 unlisted Hazard Symbols: XN Risk Phrases: 22 40 42/43 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Harmful if swallowed. Limited evidence of a carcinogenic effect. May cause sensitization by inhalation and skin contact.The toxicological properties of this material have not been fully investigated.Mutagen. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. Skin contact may cause an allergic skin reaction (sensitization) in a small proportion of individuals. Ingestion: Harmful if swallowed. May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated. Inhalation: May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. May cause dyspnea (difficult or labored breathing). May cause respiratory sensitization. Chronic: Laboratory experiments have resulted in mutagenic effects. Section 4 - FIRST AID MEASURES Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid. Skin: In case of contact, flush skin with plenty of water. Remove contaminated clothing and shoes. Get medical aid if irritation develops and persists. Wash clothing before reuse. Ingestion: If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid. Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Treat symptomatically and supportively. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or appropriate foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 11006-33-0: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: blue Odor: odorless pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: Not available. Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Soluble. Specific Gravity/Density: Molecular Formula: C13H28N3O12 Molecular Weight: 418.21 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable at room temperature in closed containers under normal storage and handling conditions. Conditions to Avoid: Dust generation. Incompatibilities with Other Materials: Strong oxidizing agents. Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide. Hazardous Polymerization: Has not been reported. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 11006-33-0: SY0525000 LD50/LC50: CAS# 11006-33-0: Oral, mouse: LD50 = 371 mg/kg; Oral, rat: LD50 = 649 mg/kg. Carcinogenicity: Zeocin - Not listed by ACGIH, IARC, or NTP. Other: See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Products which are considered hazardous for supply are classified as Special Waste and the disposal of such chemicals is covered by regulations which may vary according to location. Contact a specialist disposal company or the local waste regulator for advice. Empty containers must be decontaminated before returning for recycling. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XN Risk Phrases: R 22 Harmful if swallowed. R 40 Limited evidence of a carcinogenic effect. R 42/43 May cause sensitization by inhalation and skin contact. Safety Phrases: S 22 Do not breathe dust. S 36/37 Wear suitable protective clothing and gloves. WGK (Water Danger/Protection) CAS# 11006-33-0: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 11006-33-0 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 11006-33-0 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

毒理学数据: 1 。 试验方法：腹腔 摄入剂量： 50 mg/kg/10D-I 测试对象：啮齿动物-鼠 毒性类型： MutipleDose 毒性作用： 慢性数据-死亡 2 。 试验方法： 摄入剂量： 200毫微克/盘 测试对象：细菌-大肠杆菌 毒性类型：突变 毒性作用： 详细的毒副作用没有报告以外的其他致死剂量值。 3 。 试验方法： 摄入剂量： 500 ug/L/30M 测试对象：细菌-大肠杆菌 毒性类型：突变 毒性作用： 详细的毒副作用没有报告以外的其他致死剂量值。 生态学数据: 该物质对环境可能有危害，对水体应给予特别注意。 CHEMICAL IDENTIFICATION RTECS NUMBER : SY0525000 CHEMICAL NAME : Phleomycin CAS REGISTRY NUMBER : 11006-33-0 LAST UPDATED : 199806 DATA ITEMS CITED : 21 MOLECULAR FORMULA : C13-H28-N3-O12 MOLECULAR WEIGHT : 418.44 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 649 mg/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 4 mg/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 371 mg/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 13 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 25 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 21 mg/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 2500 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 13 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 50 mg/kg/10D-I TOXIC EFFECTS : Related to Chronic Data - death TYPE OF TEST : Sex chromosome loss and nondisjunction TYPE OF TEST : Cytogenetic analysis MUTATION DATA TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Rodent - mouse Ovary DOSE/DURATION : 1 mg/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 6,289,1968

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302
• 个人防护装备: dust mask type N95 (US);Eyeshields;Gloves
• 危害码 (欧洲): Xn: Harmful;Xi: Irritant;
• 风险声明 (欧洲): R22
• 安全声明 (欧洲): 26-36
• 危险品运输编码: UN 2811
• WGK德国: 3
• RTECS号: SY0525000
• 包装等级: III
• 危险类别: 6.1(b)