查看所有供应商和价格请点击：

174636-32-9

174636-32-9结构式

中文名	(-)-(S)-N-(alpha-乙基苄基)-3-羟基-2-苯基喹啉-4-羧酰胺
英文名	3-hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide
中文别名	(S)-3-羟基-2-苯基-N-(1-苯丙基)喹啉-4-甲酰胺 3-羟基-2-苯基-N-[(1S)-1-苯基丙基]-4-喹啉甲酰胺 (S)-3-羟基-2-苯基-N-(1-苯基丙基)喹啉-4-甲酰胺他尔奈坦
英文别名	3-Hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecboxamide (S)-3-Hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-cboxamide SB-223412; SB223412; SB 4-Quinolinecboxamide, 3-hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl] 3-hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-cboxamide (-)-3-Hydroxy-2-phenyl-N-[1(S)-phenylpropyl]quinoline-4-cboxamide Talnetant, 10 mM in DMSO 3-hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-cboxamide schizophrenia,SB223412,NK rector,Inhibitor,hNK-2,Talnetant,Neurokinin Rector,Tachykinin rector,NK3 rector,SB-223412,inhibit Talnetant/(S)-3-hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-cboxamide (-)-(S)-N-(alpha-ethylbenzyl)-3-hydroxy-2-phenylquinoline-4-cboxaMide UNII-CZ3T9T146K (S)-N-(1-Phenylpropyl)-3-hydroxy-2-phenylquinoline-4-carboxamide,SB-223412 TALNETANT//SB223412//3-hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-cboxaMide (S)-N-(1-Phenylpropyl)-3-hydroxy-2-phenylquinoline-4-cboxamide

描述	Talnetant (SB 223412)是高活性NK3受体选择性拮抗剂,Ki为1.4 nM,比对hNK-2受体的抑制性高100倍,对hNK-1无亲和性。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> 神经激肽受体信号通路 >> 神经信号通路 >> 神经激肽受体研究领域 >> 神经疾病
参考文献	[1]. Giardina GA, et al. Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 2. Identification of (S)-N-(1-phenylpropyl)-3-hydroxy-2-phenylquinoline-4-carboxamide (SB 223412). J Med Chem. 1999 Mar 25;42(6):1053- [2]. Houghton LA, et al. Effect of the NK(3) receptor antagonist, talnetant, on rectal sensory function and compliance in healthy humans. Neurogastroenterol Motil. 2007 Sep;19(9):732-43. [3]. Dawson LA, et al. In vitro and in vivo characterization of the non-peptide NK3 receptor antagonist SB-223412 (talnetant): potential therapeutic utility in the treatment of schizophrenia. Neuropsychopharmacology. 2008 Jun;33(7):1642-52.