153439-40-8

• 常用中文名：盐酸非索非那定
• 常用英文名：Fexofenadine hydrochloride
• CAS号：153439-40-8
• 分子式：C₃₂H₄₀ClNO₄
• 分子量：538.117
• 相关类别： 生物化工 抑制剂 神经信号通路(Neuronal Signaling) Histamine Receptor 抑制剂
• 发布时间：2018-04-17 08:00:00
• 更新时间：2026-06-29 20:34:20
• Fexofenadine是第三代抗组胺药,用于治疗过敏症状,如花粉热,鼻塞和荨麻疹。

名称

• 中文名: 盐酸非索非那定
• 英文名: Fexofenadine Hydrochloride
• 中文别名: 索那定盐酸盐; 非索那定盐酸盐; 盐酸非索芬那定; FEXOFENADINE HYDROCHLORIDE 盐酸非索非那定; 非索非那定盐酸盐; FEXOFENADINE HCL 盐酸非索非那定; FEXOFENADINE-D10旽CL; 非索芬那定HCL; alpha,alpha-二甲基-4-[1-羟基-4-[4-(羟基二苯甲基)-1-派啶]丁基]-苯乙酸盐酸盐; 乙腈中盐酸非索非那定; FEXOFENADINE HYDROCHLORIDE,H1 RECTOR拮抗剂; 非索芬那定盐酸盐; 2-(4-(1-羟基-4-(4-(羟基二苯甲基)哌啶-1-基)丁基)苯基)-2-甲基丙酸 盐酸盐; 盐酸非索非那定 153-8; 盐酸非索非那定 标准品; 盐酸非索非那定对照品; 盐酸非索非那丁; 盐酸非索非那定 盐酸盐153-8; 盐酸非索非那定 其他西药原料; Benzeneacetic acid, 4-​[1-​hydroxy-​4-​[4-​(hydroxydiphenylmeth​yl)​-​1-​piperidinyl]​butyl]​-​α,​α-​dimethyl-​, hydrochloride
• 英文别名: Fexofenadine HCl; 4-[1-Hydroxy-4-[4-(hydroxydiphenylMethyl)-1-piperidinyl]butyl]-α,α-diMethylbenzeneacetic Acid Hydrochloride; benzeneacetic acid, 4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-α,α-dimethyl-, hydrochloride; Fexofenidine hydrochloride,MDL 16455 hydrochloride,Terfenidine carboxylate hydrochloride; Fexofenadine Hydrochloride IP//Ph. Eur/BP; Fexofenadine (hydrochloride); Fexofenadine Hydrochloride (Y000789)Q: What is Fexofenadine Hydrochloride (Y000789) Q: What is the CAS Number of Fexofenadine Hydrochloride (Y000789); 2-[4-[1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butyl]phenyl]-2-methyl-propanoic acid hydrochloride; Allea; 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic aci; FERULICACIDPIPERAZINE; Feksine; 2-[4-[1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]-1-piperidyl]butyl]phenyl]-2-methyl-propionic acid hydrochloride; Fexofenadine Hydrochloride RS; 2-{4-[(1R)-1-hydroxy-4-[4-(hydroxydiphenylMethyl)piperidin-1-yl]butyl]phenyl}-2-Methylpropanoic acid; Fexofenadine hydrochloride, H1 rector antagonist; Terfenadinecboxylate Hydrochloride; Benzeneacetic acid, 4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-α,α-dimethyl-, hydrochloride (1:1); Fexofen; Fexadyne; Fexofenadine hydrochloride,Fexofenidine hydrochloride, MDL 16455 hydrochloride, Terfenidine cboxylate hydrochloride; FEXOFENADINE-D10 HCL; Fexofenadine hydrochloride CRS; α,α-Dimethyl-4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-benzeneaceticacidhydrochloride; Fexo; Benzeneaceticacid, 4-[1-hydroxy-4-[4-(hydroxydiphenylMethyl)-1-piperidinyl]butyl]-a,a-diMethyl-,hydrochloride (1:1); 2-[4-[1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butyl]phenyl]-2-methylpropanoic acid hydrochloride; Fexofenadine hydrochloride Fexofenadine hcl; (Cboxyterfenadine-D10,Terfenadinecboxylate); benzeneacetic acid, 4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-a,a-dimethyl-, hydrochloride (1:1); FexofenadineHydrochloride>; Fexofenadine hydrochloride salt; Benzeneacetic acid, 4-​[1-​hydroxy-​4-​[4-​(hydroxydiphenylmeth​yl)​-​1-​piperidinyl]​butyl]​-​α,​α-​dimethyl-​, hydrochloride; α,α-dimethyl-4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]benzeneacetic acid; Fexofenadine hydrochloride //BP; Telfast BD; Fexofenadine hydrochloride 100 μg/mL in Acetonitrile; Fexofenadine HCl - Bio-X; Telfast; Fexofenadine HydrochlorideQ: What is Fexofenadine Hydrochloride Q: What is the CAS Number of Fexofenadine Hydrochloride Q: What is the storage condition of Fexofenadine Hydrochloride Q: What e the applications of Fexofenadine Hydrochloride; Vivafeks; Fexofenidine hydrochloride, MDL 16455 hydrochloride, Terfenidine cboxylate hydrochloride; Non - Determination of hydrochloride; 2-[4-(1-hydroxy-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}butyl)phenyl]-2-methylpropanoic acid hydrochloride; (138-8) fexofenadine hydrochloride; Benzeneacetic acid, 4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-α,α-dimethyl-, hydrochloride; 2-[4-(1-Hydroxy-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}butyl)phenyl]-2-methylpropansäurehydrochlorid; Fexofenidine hydrochloride MDL 16455 hydrochloride Terfenidine carboxylate hydrochloride; MDL 16455A; Alernex; (R)-2-(4-(1-hydroxy-4-(4-(hydroxydiphenylMethyl)piperidin-1-yl)butyl)phenyl)-2-Methylpropanoic acid hydrochloride; FEXOFENADINE HYDROCHLORIDE; 2-[4-(1-Hydroxy-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}butyl)phenyl]-2-methylpropanoic acid hydrochloride (1:1); acide 2-[4-(1-hydroxy-4-{4-[hydroxy(diphényl)méthyl]pipéridin-1-yl}butyl)phényl]-2-méthylpropanoïque chlorhydrate; MFCD08064193; 153-8 Fexofenadine hydrochloride; UNII:2S068B75ZU; Fexofenadine(Hclform); 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid h; feofenadine hydrochloride; 2-[4-(1-Hydroxy-4-{4-[hydroxy(diphenyl)methyl]-1-piperidinyl}butyl)phenyl]-2-methylpropanoic acid hydrochloride (1:1); Fexofenadine Hydrochloride IP/BP; Cboxyterfenadine Hydrochloride; 2-[4-[1-Hydroxy-4-[4-(hydroxy-diphenyl-methyl)-1-piperidyl]-butyl]phenyl]-2-methyl-propanoic acid hydrochloride; Fexofenadine hydrochloride b

物化性质

• 熔点: 148-150oC
• 分子式: C₃₂H₄₀ClNO₄
• 分子量: 538.117
• 精确质量: 537.264587
• PSA: 81.00000
• LogP: 6.25040
• 外观性状: 固体;White to Almost white powder to crystal
• 储存条件: −20°C
• 水溶解性: 可溶于：甲醇

生物活性

• 描述: Fexofenadine是第三代抗组胺药,用于治疗过敏症状,如花粉热,鼻塞和荨麻疹。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体
  信号通路 >> 免疫及炎症 >> 组胺受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Bachert C, et al. A review of the efficacy of desloratadine, fexofenadine, and levocetirizine in the treatment of nasal congestion in patients with allergic rhinitis. Clin Ther 31 (5): 921-44.

  [2]. Compalati E, et al. Systematic review on the efficacy of fexofenadine in seasonal allergic rhinitis: a meta-analysis of randomized, double-blind, placebo-controlled clinical trials.". International Archives of Allergy and Immunology 156 (1): 1-15.

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危害码 (欧洲): Xi
• 风险声明 (欧洲): 36/37/38
• 安全声明 (欧洲): 26-36
• 危险品运输编码: NONH for all modes of transport