3973-18-0

• 常用中文名：丙炔醇乙氧基化合物
• 常用英文名：Propynol Ethoxylate
• CAS号：3973-18-0
• 分子式：C₅H₈O₂
• 分子量：100.116
• 相关类别： 信号通路 蛋白裂解靶向嵌合体 PROTAC Linker
• 发布时间：2018-07-12 08:28:53
• 更新时间：2026-07-01 09:09:17
• Propynol Ethoxylate 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

名称

• 中文名: 丙炔醇乙氧基化合物
• 英文名: Propynol Ethoxylate
• 中文别名: 丙炔-单乙二醇-羟基; MONOCLONAL ANTI-CYSTATIN B 小鼠抗; 2-(2-丙炔-1-基氧基)乙醇; 丙炔醇乙氧基醚; 乙氧基化丙炔醇PME; 重组人 Cystatin E/CST6蛋白 (His标签)-PKSH032326; PME 羟乙基炔丙基醚; PME羟乙基炔丙基醚 / 丙炔醇乙氧基醚; PME-100丙炔醇乙氧基醚; 炔醇乙氧基醚; PME 丙炔醇乙氧基化合物; CST6 多克隆抗体-E-AB-14922; 重组小鼠CST6蛋白(HIS TAG); 丙炔醇丙/乙氧基醚; 丙炔醇乙氧基化物; Cytochrome b 多克隆抗体-E-AB-16373; 羟乙基炔丙基醚(PME); 炔基乙二醇羟基; 乙氧基丙炔醇; PME羟乙基炔丙基醚 / 丙炔醇乙氧基醚 PROPYNE ETHOXYLATE; 炔基单聚乙二醇羟基; 羟乙基炔丙基醚; 丙炔醇乙氧基化物(PME); 羟基-乙二醇-丙炔; 2-(2-丙炔氧基)乙醇; 果胶果酯酶; 丙炔醇乙氧基化合物(PME); 丙炔醇乙氧基化合物,PROPGYL-PEG2-ALCOHOL; 炔丙基-PEG2-醇; 丙炔-二聚乙二醇; PME 丙炔醇乙氧基化物; 人胱抑素B(CSTB)ELISA试剂盒 YB70285Hu
• 英文别名: HC=CH2-PEG1-OH; ethoxyL; Cytochrome b-c1 complex subunit 3; Recombinant Mouse Cst6 Protein, His Tag; Recombinant Human Cystatin M/CST6 Protein, His Tag; 3-Oxa-5-hexyne-1-ol; Stefin B; Ethanol, 2-(2-propyn-1-yloxy); HC≡C-CH2-PEG1-OH; Propynol ethoxylate; Ubiquinol-cytochrome-c reductase complex cytochrome b subunit; 2-(prop-2-yn-1-yloxy)ethan-1-ol; HO-PEG1-Propgyl; Propyne ethoxylate; ISOVALERYL-W-STA-A-STA-OCH3; Anti-Stefin B antibody produced in rabbit; 2-prop-2-ynoxyethanol; PSTATIN A METHYL ESTER; Anti-CSTB (C-terminal) antibody produced in goat; MFCD06411441; Hydroxyethyl propypgyl ether (PME); Ethylene glycol monopropgyl ether; 3-(2-Hydroxyethoxy)-1-propyne; 2-(prop-2-ynyloxy)ethanol; 2-(Prop-2-yn-1-yloxy)ethanol; Complex III subunit III; propgyl alcohol ethoxylate; EINECS 223-601-1; 2-(2-propynyloxy)Ethanol; Alkyne-PEG1-OH; Propgyl-PEG1-OH; Ethanol, 2-(2-propynyloxy); CST6; Propynol Ethoxylate (>; Liver Thiol Proteinase Inhibitor; ISOVALERYL-V-V-STA-A-STA-OCH3; PME (Propynol ethoxylate); 2-(2-Propyn-1-yloxy)ethanol; Cystatin B human; MTCYB; 4-oxa-1-hexyn-6-ol; 2-(2-propynyloxy)Ethanol，Propgyl alcohol mono ethanol ether; Complex III subunit 3; ANTI-CYTB (CENTER) antibody produced in rabbit; PME; HO-PEG1-Propyne; cystatin B (stefin B); Ethoxy propinealcohol; Ethoxylated propgyl alcohol; 2-(2-propynyloxy)-ethano; Propynol ethoxylate (PME); MT-CYB

物化性质

• 密度: 1.0±0.1 g/cm3
• 沸点: 168.7±15.0 °C at 760 mmHg
• 分子式: C₅H₈O₂
• 分子量: 100.116
• 闪点: 68.9±14.6 °C
• 精确质量: 100.052429
• PSA: 29.46000
• LogP: -0.25
• 外观性状: 无色至淡黄色液体
• 蒸汽压: 0.5±0.7 mmHg at 25°C
• 折射率: 1.446
• 储存条件: -20°C

生物活性

• 描述: Propynol Ethoxylate 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC Linker
• 靶点:

  PEGs

• 体外研究: PROTACs包含两种不同的配体,它们通过连接体连接；一种是E3泛素连接酶的配体,另一种是靶蛋白的配体。PROTACs利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白[1]。
• 参考文献:

  [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

安全

• 危害码 (欧洲): Xi
• 风险声明 (欧洲): 36
• 安全声明 (欧洲): 26

合成路线

107-21-1 106-96-7 ~60% 3973-18-0

文献：Kislukhin, Alexander A.; Higginson, Cody J.; Hong, Vu P.; Finn Journal of the American Chemical Society, 2012 , vol. 134, # 14 p. 6491 - 6497

339531-56-5 ~% 3973-18-0

文献：RIB-X PHARMACEUTICALS, INC. Patent: WO2004/29066 A2, 2004 ; Location in patent: Page/Page column 281 ;

18938-38-0 ~67% 3973-18-0

文献：Bovicelli; Mincione; Patamia Synthetic Communications, 1991 , vol. 21, # 7 p. 907 - 913

106-96-7 ~% 3973-18-0

文献：Hoffmann-La Roche Inc. Patent: US6130239 A1, 2000 ; US 6130239 A

5390-04-5 540-51-2 ~% 3973-18-0

文献：Erver, Florian; Kuttner, Julian R.; Hilt, Gerhard Journal of Organic Chemistry, 2012 , vol. 77, # 19 p. 8375 - 8385

107-21-1 624-65-7 ~% 3973-18-0

文献：Faure,R.; Descotes,G. Bulletin de la Societe Chimique de France, 1966 , p. 1569 - 1575 Full Text Show Details Bottini,A.T. et al. Journal of Organic Chemistry, 1965 , vol. 30, p. 2988 - 2994

14846-79-8 ~% 3973-18-0

文献：Atavin,A.S. et al. Journal of Organic Chemistry USSR (English Translation), 1967 , vol. 3, p. 10 - 12 Zhurnal Organicheskoi Khimii, 1967 , vol. 3, # 1 p. 12 - 15

39115-81-6 107-07-3 ~% 3973-18-0

文献：Pola,J. et al. Collection of Czechoslovak Chemical Communications, 1978 , vol. 43, p. 760 - 768

上下游产品

上游产品  10
107-21-1 106-96-7 339531-56-5 18938-38-0
5390-04-5 540-51-2 624-65-7 14846-79-8
39115-81-6 107-07-3
下游产品  4
18668-74-1 111-45-5 69392-36-5 51580-41-7