382-67-2

• 常用中文名：去羟米松
• 常用英文名：Desoximetasone
• CAS号：382-67-2
• 分子式：C₂₂H₂₉FO₄
• 分子量：376.462
• 相关类别： 分析化学 标准品 法医和兽医标准品
• 发布时间：2018-02-14 08:00:00
• 更新时间：2026-07-01 21:19:23
• Desoximetasone(Topicort)是一种皮质类固醇,可用于缓解皮疹等多种皮肤疾病。
• 用于治疗炎症引起的一些条件，如过敏反应，湿疹和牛皮癣的外用类固醇。

名称

• 中文名: 去羟米松
• 英文名: desoximetasone
• 中文别名: 9-氟-11Β,21-二羟基-16Α-甲基孕甾-1,4-二烯-3,20-二酮; 去羟米松,10 MM DMSO 溶液; 去羟米松溶液,100PPM; 去氧米松; 去氧米托索; 地塞米松杂质杂质F; DESOXIMETASONE 去羟米松; 去羟米松 标准品; 解吸西米松杂质; 去氧肟酮; 去羟米松/地塞米松杂质F; 区羟米松; 脱氧米松 标准品; 去羟米松DESOXIMETASONE; (8S,9R,10S,11S,13S,14S,16R,17S)-9-氟-11-羟基-17-(2-羟基乙酰基)-10,13,16-三甲基-6,7,8,9,10,11,12,13,14,15,16,17-十二氢-3H-环戊二烯并[A]菲-3-酮; 地塞米松磷酸钠杂质F; 脱氧米松; 地塞米松杂质F; 地塞米松杂质6(地塞米松杂质F); 脱羟氟美松; 脱氧迈大松; 妥布霉素地塞米松杂质F; 去肟酶酮; 地塞米松磷酸酯杂质; 去羟米松(地塞米松杂质)
• 英文别名: Dexamethasone Impurity G; Dexamethasone Impurity F; Dexamethasone impurity 1/Dexamethasone impurity F/(8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one; Desoxymetasone F; esoximetasone; 1,4-PREGNADIEN-9-ALPHA-FLUORO-16-ALPHA-METHYL-11-BETA, 21-DIOL-3,20-DIONE; 9-Fluoro-11-β,21-dihydroxy-16-α-methylpregna-1,4-diene-3,20-dione; 17-DeoxydexaMethasone; (8S,9R,10S,11S,13S,14S,16R,17S); Pregna-1,4-diene-3,20-dione,9-fluoro-11,21-dihydroxy-16-Methyl-, (11b,16a); Topisolon; desoximetasone [INN_en]; Desoxymetasone; Dexamethasone Impurity -F; desoxymethasone; 17-Deoxymethasone; Dexamethasone Impurity F (desoxydexamethasone); deoxymethasone; desoximetasonum [INN_la]; Desoxymetasone D5; Desoximetasone,9-Fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione; Stidex; Desoximetasone 40; DESOXYMETASONE; EINECS 206-845-3; Desoximetasona; (11β,16α)-9-Fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione; Desoximetasonum; r2113; Tobramycin and dexamethasone impurity F; pregna-1,4-diene-3,20-dione,9-fluoro-11,21-dihydroxy-16-methyl-,(11-beta,16; 1, 4-PREGNADIEN-9α-FLUORO-16α-METHYL-11β, 21-DIOL-3, 20-DIONE; 20-dione,9-fluoro-11-beta,21-dihydroxy-16-alpha-methyl-pregna-4-diene-3; 9-fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione; Desoximetasone Solution, 100ppm; 9-fluoro-11b,21-dihydroxy-16a-methylpregna-1,4-diene-3,20-dione; (11β,16α)-9-Fluoro-11,21-dihydroxy-16-Methyl-pregna-1,4-diene-3,20-dione; DESOXIMETASONE;A ;17-DEOXY DEXAMETHASONE;HOE; Dexamethasone Impurity 6(Dexamethasone Impurity F); a41304; Desoximetasone, 10 mM in DMSO; DESOXIMETASONE; 17-deoxymethansone; desoximetasona [INN_es]; Desoximetason; Desoximethasone; (8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-triMethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one; topicorte; 9-FLUORO-11BETA,21-DIHYDROXY-16ALPHA-METHYLPREGNA-1,4-DIENE-3,20-DIONE; MFCD00083301; Pregna-1,4-diene-3,20-dione, 9-fluoro-11,21-dihydroxy-16-methyl-, (11β,16α); Dexamethasone Imp F; 21-desoxybetamethasone; 9-Fluoro-16α-Methyl-1-corticosterone; 9-Fluoro-11beta,21-dihydroxy-16alph; 17-desoximethasone

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 532.3±50.0 °C at 760 mmHg
• 熔点: 217ºC
• 分子式: C₂₂H₂₉FO₄
• 分子量: 376.462
• 闪点: 275.7±30.1 °C
• 精确质量: 376.204987
• PSA: 74.60000
• LogP: 2.20
• 外观性状: 白色
• 蒸汽压: 0.0±3.2 mmHg at 25°C
• 折射率: 1.574
• 储存条件: Refrigerator

生物活性

• 描述: Desoximetasone(Topicort)是一种皮质类固醇,可用于缓解皮疹等多种皮肤疾病。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Desoximetasone, From Wikipedia

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TU3834000 CHEMICAL NAME : Pregna-1,4-diene-3,20-dione, 9-fluoro-11-beta,21-dihydroxy-16-alpha-methyl- CAS REGISTRY NUMBER : 382-67-2 LAST UPDATED : 199612 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C22-H29-F-O4 MOLECULAR WEIGHT : 376.51 WISWESSER LINE NOTATION : L E5 B666 OV AHTTT&J A1 BF CQ E1 FV1Q G1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 225 ug/kg SEX/DURATION : female 8-16 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 71,367,1975 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 900 ug/kg SEX/DURATION : female 8-16 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - other effects Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 71,367,1975 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 4800 ug/kg SEX/DURATION : female 7-15 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 71,367,1975 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 3600 ug/kg SEX/DURATION : female 7-15 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - other effects Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 71,367,1975

安全

• 符号: GHS07, GHS08
• 信号词: Warning
• 危害声明: H302-H312-H315-H317-H319-H332-H335-H351
• 警示性声明: P261-P280-P305 + P351 + P338
• 个人防护装备: Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
• 危害码 (欧洲): Xn:Harmful;
• 风险声明 (欧洲): R20/21/22;R36/37/38;R40;R43
• 安全声明 (欧洲): S22-S26-S36
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3
• RTECS号: TU3834000
• 海关编码: 2914700090

合成路线

50-02-2 ~83% 382-67-2

文献：TARO PHARMACEUTICAL INDUSTRIES LTD.; CHERNIAK, Simon; CYJON, Rosa; OZER, Ilana; NUDELMAN, Igor Patent: WO2012/11106 A1, 2012 ; Location in patent: Page/Page column 15-16 ;

上下游产品

上游产品  1
50-02-2
下游产品  1
75262-69-0

海关

海关编码	2914700090
中文概述	2914700090 其他酮及醌的卤化、磺化衍生物（包括硝化和亚硝化衍生物）. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:5.5% 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 丙酮报明包装
Summary	HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%