152-97-6

• 常用中文名：氟可龙
• 常用英文名：Fluocortolone
• CAS号：152-97-6
• 分子式：C₂₂H₂₉FO₄
• 分子量：376.462
• 相关类别： 原料药 激素及调节内分泌功能类药 肾上腺皮质激素类药
• 发布时间：2018-04-26 08:00:00
• 更新时间：2024-01-02 11:49:32
• Fluocortolone 是一种口服有效的抗炎剂,可有效降低血浆纤维蛋白原水平。Fluocortolone 在大鼠的佐剂关节型炎症模型中抑制 Mycobacterium butyricum 诱导的足部水肿 (3-12 mg/kg)。

名称

• 中文名: 氟可龙
• 英文名: Fluocortolone
• 英文别名: FLUORCORTOLONE; Pregna-1,4-diene-3,20-dione, 6-fluoro-11,21-dihydroxy-16-methyl-, (6α,11β,16α)-; SH-742; 6a-Fluoro-16a-methyl-1-dehydrocorticosterone; Fluorocortolone; Fluocortolon; flucortolone; 6a-Fluoro-16a-methyl-D1,4-pregnadiene-11b,21-diol-3,20-dione; EINECS 205-811-5; (6α,11β,16α)-6-Fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione; methylfluorodehydrocorticosterone; Fluocortolone

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 537.4±50.0 °C at 760 mmHg
• 熔点: 113-116ºC
• 分子式: C₂₂H₂₉FO₄
• 分子量: 376.462
• 闪点: 278.8±30.1 °C
• 精确质量: 376.204987
• PSA: 74.60000
• LogP: 1.86
• 外观性状: 淡黄色固体
• 蒸汽压: 0.0±3.2 mmHg at 25°C
• 折射率: 1.572
• 储存条件: 2~8°C
• 分子结构:

  1、 摩尔折射率：98.61

  2、 摩尔体积（cm³/mol）：299.9

  3、 等张比容（90.2K）：796.6

  4、 表面张力（dyne/cm）：49.7

  5、 极化率（10-24cm3）：39.09

生物活性

• 描述: Fluocortolone 是一种口服有效的抗炎剂,可有效降低血浆纤维蛋白原水平。Fluocortolone 在大鼠的佐剂关节型炎症模型中抑制 Mycobacterium butyricum 诱导的足部水肿 (3-12 mg/kg)。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Bhargava A S. Effect of anti-inflammatory agents on adjuvant-induced edema modified for primary test[J]. Pharmacological Research Communications, et al. Effect of anti-inflammatory agents on adjuvant-induced edema modified for primary test[J]. Pharmacological Research Communications, 1971, 3(1): 83-91. .

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TU3832500 CHEMICAL NAME : Pregna-1,4-diene-3,20-dione, 6-alpha-fluoro-11-beta,21-dihydroxy-16-alpha-methyl- CAS REGISTRY NUMBER : 152-97-6 LAST UPDATED : 199612 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C22-H29-F-O4 MOLECULAR WEIGHT : 376.51 WISWESSER LINE NOTATION : L E5 B666 OV AHTTT&J A1 CQ E1 FV1Q G1 LF HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 70 mg/kg SEX/DURATION : female 12 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : YKRYAH Yakubutsu Ryoho. Medicinal Treatment. (Tokyo, Japan) V.1-14, 1968-81. Suspended. Volume(issue)/page/year: 9,1623,1976 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 20 mg/kg SEX/DURATION : female 12 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : YKRYAH Yakubutsu Ryoho. Medicinal Treatment. (Tokyo, Japan) V.1-14, 1968-81. Suspended. Volume(issue)/page/year: 9,1623,1976 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 70 mg/kg SEX/DURATION : female 13 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) REFERENCE : YKRYAH Yakubutsu Ryoho. Medicinal Treatment. (Tokyo, Japan) V.1-14, 1968-81. Suspended. Volume(issue)/page/year: 9,1623,1976 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 70 mg/kg SEX/DURATION : female 13 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) REFERENCE : YKRYAH Yakubutsu Ryoho. Medicinal Treatment. (Tokyo, Japan) V.1-14, 1968-81. Suspended. Volume(issue)/page/year: 9,1623,1976 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Administration onto the skin DOSE : 2500 ug/kg SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : AMBED4 AMI-Berichte. (Berlin, Fed. Rep. Ger.) No. 1-2, 1978-82. Volume(issue)/page/year: (1),127,1988 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 30 mg/kg SEX/DURATION : female 7-18 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) REFERENCE : YKRYAH Yakubutsu Ryoho. Medicinal Treatment. (Tokyo, Japan) V.1-14, 1968-81. Suspended. Volume(issue)/page/year: 10,151,1977

安全

• 危害码 (欧洲): Xn
• 海关编码: 2942000000

海关

海关编码	2942000000