638-94-8

• 常用中文名：地索奈德
• 常用英文名：Desonide
• CAS号：638-94-8
• 分子式：C₂₄H₃₂O₆
• 分子量：416.507
• 相关类别： 生物化工 抑制剂 内分泌及激素(Endocrinology & Hormones) Glucocorticoid Receptor 激动剂
• 发布时间：2018-09-27 23:07:41
• 更新时间：2024-01-01 19:00:44
• 甾体类皮质激素，治疗内源性湿疹。

名称

• 中文名: 地索奈德
• 英文名: desonide
• 英文别名: Prednacinolone; (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one; 16a,17a-Isopropylidenedioxyprednisolone; 2H-naphth[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one, 4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-, (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-; Desowen; 2H-Naphth[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one, 4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-5-hydroxy-6b-(2-hydroxyacetyl)-4a,6a,8,8-tetramethyl-, (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-; Locapred; Desonide; (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacétyl)-4a,6a,8,8-tétraméthyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodécahydro-2H-naphto[2',1':4,5]indéno[1,2-d][1,3]dioxol-2-one; Sterax; 11b,16a,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione Cyclic 16,17-Acetal with Acetone; 16a-Hydroxy-D1-hydrocortisone-16a,17a-acetonide; 16a-Hydroxyprednisolone-16a,17-acetonide; Steroderm; 16a-Hydroxyprednisolone Acetonide; TRIDESILON; desonidum [INN_la]; MFCD00866151; 11β,16α,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone; (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-Hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-on; (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-6b-Glycoloyl-5-hydroxy-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one; 11b,21-Dihydroxy-16a,17-isopropylidenedioxy-1,4-pregnadiene-3,20-dione; Topifug; d-2083; EINECS 211-351-6; 11,21-Dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione; Budesonide Impurity 6

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 580.1±50.0 °C at 760 mmHg
• 熔点: 274 - 275ºC
• 分子式: C₂₄H₃₂O₆
• 分子量: 416.507
• 闪点: 196.9±23.6 °C
• 精确质量: 416.219879
• PSA: 93.06000
• LogP: 2.62
• 外观性状: 固体;White to Almost white powder to crystal
• 蒸汽压: 0.0±3.7 mmHg at 25°C
• 折射率: 1.598
• 储存条件: Refrigerator

生物活性

• 描述: Desonide是非氟化皮质类固醇抗炎剂,能作用于糖皮质激素受体。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 糖皮质激素受体
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Kahanek, N., C. Gelbard, and A. Hebert, Desonide: a review of formulations, efficacy and safety. Expert Opin Investig Drugs, 2008. 17(7): p. 1097-104.

  [2]. Castanedo-Cazares, J.P., et al., Topical niacinamide 4% and desonide 0.05% for treatment of axillary hyperpigmentation: a randomized, double-blind, placebo-controlled study. Clin Cosmet Investig Dermatol, 2013. 6: p. 29-36.

  [3]. Parish, D. and N. Scheinfeld, Desonide foam: a review. Drugs Today (Barc), 2008. 44(1): p. 55-62.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TU2800000 CHEMICAL NAME : Prednisolone-16,17-acetonide, 16-alpha-hydroxy- CAS REGISTRY NUMBER : 638-94-8 LAST UPDATED : 199203 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C24-H32-O6 MOLECULAR WEIGHT : 416.56 WISWESSER LINE NOTATION : T F5 E5 B666 GO IO RV AHTTTT&J A1 CQ E1 FV1Q H1 H1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 93 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 20,522,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3710 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,111,1970

安全

• 危害码 (欧洲): Xn
• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2937210000

合成路线

13951-70-7 ~% 638-94-8

文献：Journal of the American Chemical Society, , vol. 81, p. 4573

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