638-94-8

• 常用中文名：地索奈德
• 常用英文名：Desonide
• CAS号：638-94-8
• 分子式：C₂₄H₃₂O₆
• 分子量：416.507
• 相关类别： 生物化工 抑制剂 内分泌及激素(Endocrinology & Hormones) Glucocorticoid Receptor 激动剂
• 发布时间：2018-09-27 23:07:41
• 更新时间：2026-07-01 14:36:44
• Desonide是非氟化皮质类固醇抗炎剂,能作用于糖皮质激素受体。

名称

• 中文名: 地索奈德
• 英文名: desonide
• 中文别名: 布地奈德F; (11Β,16Α)-11,21-二羟基-16,17-[(1-甲基亚乙基)双(氧)]孕-1,4-二烯-3,20-二酮; 湖北地索奈德原料药; 羟泼尼缩松; 布地奈德杂质F(地奈德); 乙腈中地索奈德溶液,100ΜG/ML; 布地奈德杂质06; 地奈德; 布地奈德杂质6(布地奈德杂质F); 布地奈德杂质F; 地索奈德原料药; 地奈德原料; 地索奈德 标准品; 地索奈德(中间体); 地索奈德杂质16; Desonide 10mM * 1mL in DMSO试剂; 地索萘德; 地索奈德 现货; 地索奈德原料; 地索耐德; 布地奈德杂质F(去索尼德); 待索利德; 11BETA,21-二羟基-16ALPHA,17ALPHA-(亚异丙基二氧基)孕甾-1,4-二烯-3,20-二酮; Desonide 10mg试剂; 地奈德原料药; 地奈德 标准品; 地奈德(布地奈德杂质F); 待索利德(地索奈德); 地奈德对照品; 布地奈德杂质F(DESONIDE); 地奈德:地索奈德; 地索奈德原料药厂; (1S,2S,4R,8S,9S,11S,12S,13R)-11-羟基-8-(2-羟基乙酰基)-6,6,9,13-四甲基-5,7-二氧杂五环[10.8.0.02,.0,.013,1]二十碳-14,17-二烯-16-酮; 地奈德杂质; 布地奈德杂质F (DESONIDE); 地奈德, Desonide 激素类; 地奈德Desonide; (6,6BS,7S,8AS,8BS,11,12AS,12BS)-7-羟基-8B-(2-羟基乙酰基)-6A,8A,10,10-四甲基-1,2,6A,6B,7,8,8A,8B,11A,12,12A,12B-十二氢-4H-萘并[2',1':4,5]茚并[1,2-D][1,3]二氧戊环-4-酮; 布地奈德杂质F(去诺德); 地索奈德 待索利德; 布地奈德-ZF; 地索奈德衍生物; 地索柰德; 地索奈德,10 MM DMSO 溶液
• 英文别名: 1,4-PREGNADIEN-11-BETA, 16-ALPHA, 17,21-TETROL-3,20-DIONE 16,17-ACETONIDE; 16alpha,17-[1-Methylethylidenebis(oxy)]-11beta,21-dihydroxypregna-1,4-diene-3,20-dione (Desonide); (11β,16α)-11,21-Dihydroxy-16,17-[(1-Methylethylidene)bis(oxy)]pregna -1,4-diene-3,20-dione; Desonade; 16a,17a-Isopropylidenedioxyprednisolone; 11beta,21-Dihydroxy-16alpha,17alpha-(isopropylidenedioxy)pregna-1,4-diene-3,20-dione; (11,16a)-11,21-Dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione; Desowen; (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacétyl)-4a,6a,8,8-tétraméthyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodécahydro-2H-naphto[2',1':4,5]indéno[1,2-d][1,3]dioxol-2-one; Pregna-1,4-diene-3,20-dione, 11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (11b,16a); Sterax; 16a-Hydroxyprednisole-16,17-acetonide; 11b,16a,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione Cyclic 16,17-Acetal with Acetone; 16a-Hydroxy-D1-hydrocortisone-16a,17a-acetonide; DesonideQ: What is Desonide Q: What is the CAS Number of Desonide Q: What is the storage condition of Desonide; 1, 4-PREGNADIEN-11β, 16α, 17, 21-TETROL-3, 20-DIONE 16, 17-ACETONIDE; TRIDESILON; Desonidemicro; Budesonide Acetonide; DesonideBioc; desonidum [INN_la]; Desonide (Budesonide Impurity F); Pregna-1,4-diene-3,20-dione, 11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (11β,16α); Desonide (Budesonide acetonide); MFCD00866151; Budesonide Impurity 6; Budesonide impurity F; steroderm; (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-Hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-on; (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-6b-Glycoloyl-5-hydroxy-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one; 16α-Hydroxyprednisolone Acetonide; 11b,21-Dihydroxy-16a,17-isopropylidenedioxy-1,4-pregnadiene-3,20-dione; d-2083; 16a,17-[1-Methylethylidenebis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione; (11b,16a)-11,21-dihydroxy-16,17-((1-methylethylidene)bis(oxy))-pregna-1,4-diene-3,20-dione; Budesonide iMpurit F; EINECS 211-351-6; (6,6bS,7S,8aS,8bS,11,12aS,12bS)-7-hydroxy-8b-(2-hydroxyacetyl)-6a,8a,10,10-tetramethyl-1,2,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-4H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4-one; The Ned; API Steriods Desonide Powder Dosage Usage Effect and Benefit; (11beta,16alpha)-11,21-Dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione; Desonide, 10 mM in DMSO; Prednacinolone; Desonide Impurity 16; (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one; Be Consolide; Desonide Solution in Acetonitrile, 100μg/mL; Locapred; 16-alpha-hydroxyprednisole-16,17-acetonide; Desonide Impurity-E; Tridesilon; Budesonide Impurity F(Desonide); Amino-2-methyl-283H-tetrazole; 16a-Hydroxyprednisolone-16a,17-acetonide; Steroderm; 16a-Hydroxyprednisolone Acetonide; Desonide, >=; PREDNACINOLONE; 16α,17-[1-methylethylidenebis(oxy)]-11β,21-dihydroxypregna-1,4-diene-3,20-dione; DESONIDE; Budesonide Impurity 6(Budesonide Impurity F); Desonide //BP; Budesonide Impurity F (Desonide); 11β,16α,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone; 17-acetonide,16-alpha-hydroxy-prednisolone-1; Topifug; Desonide/(6,6bS,7S,8aS,8bS,11,12aS,12bS)-7-hydroxy-8b-(2-hydroxyacetyl)-6a,8a,10,10-tetramethyl-1,2,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-4H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4-one; 11,21-Dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 580.1±50.0 °C at 760 mmHg
• 熔点: 274 - 275ºC
• 分子式: C₂₄H₃₂O₆
• 分子量: 416.507
• 闪点: 196.9±23.6 °C
• 精确质量: 416.219879
• PSA: 93.06000
• LogP: 2.62
• 外观性状: 固体;White to Almost white powder to crystal
• 蒸汽压: 0.0±3.7 mmHg at 25°C
• 折射率: 1.598
• 储存条件: Refrigerator

生物活性

• 描述: Desonide是非氟化皮质类固醇抗炎剂,能作用于糖皮质激素受体。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 糖皮质激素受体
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Kahanek, N., C. Gelbard, and A. Hebert, Desonide: a review of formulations, efficacy and safety. Expert Opin Investig Drugs, 2008. 17(7): p. 1097-104.

  [2]. Castanedo-Cazares, J.P., et al., Topical niacinamide 4% and desonide 0.05% for treatment of axillary hyperpigmentation: a randomized, double-blind, placebo-controlled study. Clin Cosmet Investig Dermatol, 2013. 6: p. 29-36.

  [3]. Parish, D. and N. Scheinfeld, Desonide foam: a review. Drugs Today (Barc), 2008. 44(1): p. 55-62.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TU2800000 CHEMICAL NAME : Prednisolone-16,17-acetonide, 16-alpha-hydroxy- CAS REGISTRY NUMBER : 638-94-8 LAST UPDATED : 199203 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C24-H32-O6 MOLECULAR WEIGHT : 416.56 WISWESSER LINE NOTATION : T F5 E5 B666 GO IO RV AHTTTT&J A1 CQ E1 FV1Q H1 H1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 93 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 20,522,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3710 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,111,1970

安全

• 危害码 (欧洲): Xn
• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2937210000

合成路线

13951-70-7 ~% 638-94-8

文献：Journal of the American Chemical Society, , vol. 81, p. 4573

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