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638-94-8

638-94-8 structure
638-94-8 structure
  • Name: Desonide
  • Chemical Name: desonide
  • CAS Number: 638-94-8
  • Molecular Formula: C24H32O6
  • Molecular Weight: 416.507
  • Catalog: Biochemical Inhibitor Endocrinology & Hormones Glucocorticoid Receptor Agonist
  • Create Date: 2018-09-27 23:07:41
  • Modify Date: 2026-07-01 14:36:44
  • Desonide is a nonfluorinated corticosteroid anti-inflammatory agent used topically for dermatoses.Target: Glucocorticoid ReceptorDesonide is a low-potency topical corticosteroid that has been used for decades in the treatment of steroid-responsive dermatoses [1]. Desonide induced significant colorimetric improvement compared with placebo. A good to excellent response was achieved in 30% for desonide, and 6% for placebo. Decreased pigmentation in the desonide-treated axillae was associated with recovery of disruption at the basal membrane. Desonide showed depigmenting properties in women with axillary hyperpigmentation [2]. Given the favorable safety profile of all other desonide preparations and their utility as a low potency corticosteroid, desonide foam promises to be a useful addition to the armamentarium, when other desonide vehicles might be less acceptable [3].
Name desonide
Synonyms 1,4-PREGNADIEN-11-BETA, 16-ALPHA, 17,21-TETROL-3,20-DIONE 16,17-ACETONIDE
16alpha,17-[1-Methylethylidenebis(oxy)]-11beta,21-dihydroxypregna-1,4-diene-3,20-dione (Desonide)
(11β,16α)-11,21-Dihydroxy-16,17-[(1-Methylethylidene)bis(oxy)]pregna -1,4-diene-3,20-dione
Desonade
16a,17a-Isopropylidenedioxyprednisolone
11beta,21-Dihydroxy-16alpha,17alpha-(isopropylidenedioxy)pregna-1,4-diene-3,20-dione
(11,16a)-11,21-Dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
Desowen
(4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacétyl)-4a,6a,8,8-tétraméthyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodécahydro-2H-naphto[2',1':4,5]indéno[1,2-d][1,3]dioxol-2-one
Pregna-1,4-diene-3,20-dione, 11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (11b,16a)
Sterax
16a-Hydroxyprednisole-16,17-acetonide
11b,16a,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione Cyclic 16,17-Acetal with Acetone
16a-Hydroxy-D1-hydrocortisone-16a,17a-acetonide
DesonideQ: What is Desonide Q: What is the CAS Number of Desonide Q: What is the storage condition of Desonide
1, 4-PREGNADIEN-11β, 16α, 17, 21-TETROL-3, 20-DIONE 16, 17-ACETONIDE
TRIDESILON
Desonidemicro
Budesonide Acetonide
DesonideBioc
desonidum [INN_la]
Desonide (Budesonide Impurity F)
Pregna-1,4-diene-3,20-dione, 11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (11β,16α)
Desonide (Budesonide acetonide)
MFCD00866151
Budesonide Impurity 6
Budesonide impurity F
steroderm
(4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-Hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-on
(4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-6b-Glycoloyl-5-hydroxy-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
16α-Hydroxyprednisolone Acetonide
11b,21-Dihydroxy-16a,17-isopropylidenedioxy-1,4-pregnadiene-3,20-dione
d-2083
16a,17-[1-Methylethylidenebis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione
(11b,16a)-11,21-dihydroxy-16,17-((1-methylethylidene)bis(oxy))-pregna-1,4-diene-3,20-dione
Budesonide iMpurit F
EINECS 211-351-6
(6,6bS,7S,8aS,8bS,11,12aS,12bS)-7-hydroxy-8b-(2-hydroxyacetyl)-6a,8a,10,10-tetramethyl-1,2,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-4H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4-one
The Ned
API Steriods Desonide Powder Dosage Usage Effect and Benefit
(11beta,16alpha)-11,21-Dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
Desonide, 10 mM in DMSO
Prednacinolone
Desonide Impurity 16
(4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
Be Consolide
Desonide Solution in Acetonitrile, 100μg/mL
Locapred
16-alpha-hydroxyprednisole-16,17-acetonide
Desonide Impurity-E
Tridesilon
Budesonide Impurity F(Desonide)
Amino-2-methyl-283H-tetrazole
16a-Hydroxyprednisolone-16a,17-acetonide
Steroderm
16a-Hydroxyprednisolone Acetonide
Desonide, >=
PREDNACINOLONE
16α,17-[1-methylethylidenebis(oxy)]-11β,21-dihydroxypregna-1,4-diene-3,20-dione
DESONIDE
Budesonide Impurity 6(Budesonide Impurity F)
Desonide //BP
Budesonide Impurity F (Desonide)
11β,16α,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone
17-acetonide,16-alpha-hydroxy-prednisolone-1
Topifug
Desonide/(6,6bS,7S,8aS,8bS,11,12aS,12bS)-7-hydroxy-8b-(2-hydroxyacetyl)-6a,8a,10,10-tetramethyl-1,2,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-4H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4-one
11,21-Dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
Description Desonide is a nonfluorinated corticosteroid anti-inflammatory agent used topically for dermatoses.Target: Glucocorticoid ReceptorDesonide is a low-potency topical corticosteroid that has been used for decades in the treatment of steroid-responsive dermatoses [1]. Desonide induced significant colorimetric improvement compared with placebo. A good to excellent response was achieved in 30% for desonide, and 6% for placebo. Decreased pigmentation in the desonide-treated axillae was associated with recovery of disruption at the basal membrane. Desonide showed depigmenting properties in women with axillary hyperpigmentation [2]. Given the favorable safety profile of all other desonide preparations and their utility as a low potency corticosteroid, desonide foam promises to be a useful addition to the armamentarium, when other desonide vehicles might be less acceptable [3].
Related Catalog
References

[1]. Kahanek, N., C. Gelbard, and A. Hebert, Desonide: a review of formulations, efficacy and safety. Expert Opin Investig Drugs, 2008. 17(7): p. 1097-104.

[2]. Castanedo-Cazares, J.P., et al., Topical niacinamide 4% and desonide 0.05% for treatment of axillary hyperpigmentation: a randomized, double-blind, placebo-controlled study. Clin Cosmet Investig Dermatol, 2013. 6: p. 29-36.

[3]. Parish, D. and N. Scheinfeld, Desonide foam: a review. Drugs Today (Barc), 2008. 44(1): p. 55-62.
Density 1.3±0.1 g/cm3
Boiling Point 580.1±50.0 °C at 760 mmHg
Melting Point 274 - 275ºC
Molecular Formula C24H32O6
Molecular Weight 416.507
Flash Point 196.9±23.6 °C
Exact Mass 416.219879
PSA 93.06000
LogP 2.62
Vapour Pressure 0.0±3.7 mmHg at 25°C
Index of Refraction 1.598
Storage condition Refrigerator

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU2800000
CHEMICAL NAME :
Prednisolone-16,17-acetonide, 16-alpha-hydroxy-
CAS REGISTRY NUMBER :
638-94-8
LAST UPDATED :
199203
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C24-H32-O6
MOLECULAR WEIGHT :
416.56
WISWESSER LINE NOTATION :
T F5 E5 B666 GO IO RV AHTTTT&J A1 CQ E1 FV1Q H1 H1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
93 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 20,522,1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3710 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,111,1970
Hazard Codes Xn
RIDADR NONH for all modes of transport
HS Code 2937210000
13951-70-7 structure

13951-70-7

~%

638-94-8 structure

638-94-8

Literature: Journal of the American Chemical Society, , vol. 81, p. 4573
Precursor  1

DownStream  2

HS Code 2937210000
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