前往化源商城
入驻化源商城

品牌现货直购
供应商:我要出现这里





查看所有供应商和价格请点击:

53912-89-3生产厂家

53912-89-3价格

53912-89-3

53912-89-3结构式
53912-89-3结构式
  • 常用中文名:(+)-假木贼碱盐酸盐
  • 常用英文名:(+)-Anabasine hydrochloride
  • CAS号:53912-89-3
  • 分子式:C10H15ClN2
  • 分子量:198.69200
  • 相关类别: 分析化学 标准品 标准物质
  • 发布时间:2017-10-23 08:18:30
  • 更新时间:2024-01-04 17:53:03
  • (+)-Anabasine hydrochloride 是一种在烟草中发现的生物碱,是一种有效的 nAChR 激动剂。(+)-Anabasine hydrochloride 可诱导内源性表达人胎儿肌肉型 nAChRs 的 TE671 细胞去极化,EC50 值为 0.7 µM。

化源商城直购

中文名 (+)-假木贼碱盐酸盐
英文名 (S)-1,2,3,4,5,6-Hexahydro-[2,3']bipyridinyl hydrochloride
英文别名 Gamibasin
Anabasine monohydrochloride
Anabasin hydrochloride
Anabaside hydrochloride
Anabasin chloride
anabasine hydrochloride
描述 (+)-Anabasine hydrochloride 是一种在烟草中发现的生物碱,是一种有效的 nAChR 激动剂。(+)-Anabasine hydrochloride 可诱导内源性表达人胎儿肌肉型 nAChRs 的 TE671 细胞去极化,EC50 值为 0.7 µM。
相关类别
靶点

nAChR[1]

参考文献

[1]. Green BT, et, al. Actions of piperidine alkaloid teratogens at fetal nicotinic acetylcholine receptors. Neurotoxicol Teratol. May-Jun 2010; 32(3): 383-90.

[2]. Palmer-Young EC, et, al. Context-dependent medicinal effects of anabasine and infection-dependent toxicity in bumble bees. PLoS One. 2017 Aug 23; 12(8): e0183729.

密度 1.014g/cm3
沸点 271ºC at 760mmHg
分子式 C10H15ClN2
分子量 198.69200
闪点 93.3ºC
精确质量 198.09200
PSA 24.92000
LogP 3.02700
外观性状 白色至灰白色固体
储存条件 Desiccate at RT

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UT7373000
CHEMICAL NAME :
Pyridine, 3-(2-piperidinyl)-, monohydrochloride, (S)-
CAS REGISTRY NUMBER :
53912-89-3
LAST UPDATED :
199403
DATA ITEMS CITED :
10
MOLECULAR FORMULA :
C10-H14-N2.Cl-H
MOLECULAR WEIGHT :
198.72

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
235 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 14,407,1989
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
39500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 14,407,1989
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
34100 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 14,407,1989
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
24200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 14,407,1989
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
23 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 14,407,1989
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5180 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 14,407,1989
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
39 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 11,30,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
247 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 14,407,1989 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
15 mg/kg
SEX/DURATION :
female 4 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 45(1),87,1982 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.5 mg/m3 JAN 1993

符号 GHS02 GHS06 GHS08
GHS02, GHS06, GHS08
信号词 Danger
危害声明 H225-H301 + H311 + H331-H370
警示性声明 P210-P260-P280-P301 + P310-P311
危害码 (欧洲) F,T
风险声明 (欧洲) 11-23/24/25-39/23/24/25
安全声明 (欧洲) 16-36/37-45
危险品运输编码 UN1230 - class 3 - PG 2 - Methanol, solution

~94%

53912-89-3结构式

53912-89-3

文献:Kunz, Horst; Pfrengle, Waldemar Angewandte Chemie, 1989 , vol. 101, # 8 p. 1041 - 1042

~%

53912-89-3结构式

53912-89-3

文献:Synthesis, , # 10 p. 1151 - 1160

~%

53912-89-3结构式

53912-89-3

文献:Synthesis, , # 10 p. 1151 - 1160

~40%

53912-89-3结构式

53912-89-3

文献:Wojciechowska-Nowak, Marzena; Boczon, Wladyslaw; Rychlewska, Urszula; Warzajtis, Beata Journal of Molecular Structure, 2007 , vol. 840, # 1-3 p. 44 - 52

~%

53912-89-3结构式

53912-89-3

文献:Angewandte Chemie, , vol. 101, # 8 p. 1041 - 1042

~%

53912-89-3结构式

53912-89-3

文献:Angewandte Chemie, , vol. 101, # 8 p. 1041 - 1042

~%

53912-89-3结构式

53912-89-3

文献:Angewandte Chemie, , vol. 101, # 8 p. 1041 - 1042

~%

53912-89-3结构式

53912-89-3

文献:Synthesis, , # 10 p. 1151 - 1160