262352-17-0

• 常用中文名：托彻普
• 常用英文名：Torcetrapib
• CAS号：262352-17-0
• 分子式：C₂₆H₂₅F₉N₂O₄
• 分子量：600.47
• 相关类别： 生物化工 抑制剂 代谢(Metabolism) CETP 抑制剂
• 发布时间：2018-02-19 08:00:00
• 更新时间：2026-07-04 07:06:41
• Torcetrapib(CP-529414)是CETP高效抑制剂,IC50值为37nM。

名称

• 中文名: 托彻普
• 英文名: torcetrapib
• 中文别名: (2R,4S)-4-[(3,5-双三氟甲基苄基)甲氧基甲酰氨基]-2-乙基-6-三氟甲基-3,4-二氢-2H-喹啉-1-羧酸乙酯; 托彻普,10 MM DMSO 溶液; TORCETRAPIB,胆固醇酯转移蛋白(CETP)抑制剂; 托彻普杂质
• 英文别名: Torcetrapib //BP; Torcetrapib (-529414); Torcetropib; MFCD08063631; 1(2H)-Quinolinecboxylic acid, 4-[[[3,5-bis(trifluoromethyl)phenyl]methyl](methoxycbonyl)amino]-2-ethyl-3,4-dihydro-6-(trifluoromethyl)-, ethyl ester, (2R,4S); Ethyl (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl](methoxycarbonyl)amino}-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H)-carboxylate; (2R,4S)-4-[[[3,5-bis(Trifluoromethyl)phenyl]methyl](methoxycbonyl)amino]-2-ethyl-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinoline-1-cboxylicacidethylester; (2R,4S)-ethyl 2-ethyl-4-(methoxycbonyl)-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H)-cboxylate; TORCETRAPIB-D3; (2R)-ethyl 4-((3,5-bis(trifluoroMethyl)benzyl)(Methoxycbonyl)amino)-2-ethyl-6-(trifluoroMethyl)-3,4-dihydroquinoline-1(2H)-cboxylate; Ethyl (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl](methoxycarbonyl)amino}-2-ethyl-6-(trifluoromethyl)-3,4-dihydro-1(2H)-quinolinecarboxylate; Torcetrapib, 10 mM in DMSO; (2R,4S)-4-[(3,5-Bis-trifluoromethylbenzyl)methoxycbonylamino]-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-cboxylic acid ethyl ester; ethyl (2R,4S)-4-[[3,5-bis(trifluoromethyl)phenyl]methyl-methoxycarbonylamino]-2-ethyl-6-(trifluoromethyl)-3,4-dihydro-2H-quinoline-1-carboxylate; 529

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 504.8±50.0 °C at 760 mmHg
• 熔点: 54-58ºC
• 分子式: C₂₆H₂₅F₉N₂O₄
• 分子量: 600.47
• 闪点: 259.1±30.1 °C
• PSA: 59.08000
• LogP: 7.76
• 外观性状: 液体
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.512
• 储存条件: Store at RT

生物活性

• 描述: Torcetrapib(CP-529414)是CETP高效抑制剂,IC50值为37nM。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> CETP
  研究领域 >> 内分泌
• 参考文献:

  [1]. Clark RW, et al. Raising high-density lipoprotein in humans through inhibition of cholesteryl ester transfer protein: an initial multidose study of torcetrapib. Arterioscler Thromb Vasc Biol. 2004 Mar;24(3):490-7.

  [2]. Hu X, et al. Torcetrapib induces aldosterone and cortisol production by an intracellular calcium-mediated mechanism independently of cholesteryl ester transfer protein inhibition. Endocrinology. 2009 May;150(5):2211-9.

  [3]. Barter PJ, et al. Effects of torcetrapib in patients at high risk for coronary events. N Engl J Med. 2007 Nov 22;357(21):2109-22.

  [4]. Morehouse LA, et al. Inhibition of CETP activity by torcetrapib reduces susceptibility to diet-induced atherosclerosis in New Zealand White rabbits. J Lipid Res. 2007 Jun;48(6):1263-72.

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302
• 危害码 (欧洲): Xn
• 风险声明 (欧洲): 22
• 危险品运输编码: NONH for all modes of transport

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