托彻普

更新时间：2025-08-20 22:33:33

托彻普结构式	常用名	托彻普	英文名	Torcetrapib
	CAS号	262352-17-0	分子量	600.47
	密度	1.4±0.1 g/cm3	沸点	504.8±50.0 °C at 760 mmHg
	分子式	C₂₆H₂₅F₉N₂O₄	熔点	54-58ºC
	MSDS	中文版美版	闪点	259.1±30.1 °C
	符号	GHS07	信号词	Warning

托彻普用途

Torcetrapib(CP-529414)是CETP高效抑制剂,IC50值为37nM。

中文名	托彻普
英文名	torcetrapib
中文别名	(2R,4S)-4-[(3,5-双三氟甲基苄基)甲氧基甲酰氨基]-2-乙基-6-三氟甲基-3,4-二氢-2H-喹啉-1-羧酸乙酯
英文别名	更多

描述	Torcetrapib(CP-529414)是CETP高效抑制剂,IC50值为37nM。
相关类别	信号通路 >> 代谢酶/蛋白酶 >> CETP 研究领域 >> 内分泌
参考文献	[1]. Clark RW, et al. Raising high-density lipoprotein in humans through inhibition of cholesteryl ester transfer protein: an initial multidose study of torcetrapib. Arterioscler Thromb Vasc Biol. 2004 Mar;24(3):490-7. [2]. Hu X, et al. Torcetrapib induces aldosterone and cortisol production by an intracellular calcium-mediated mechanism independently of cholesteryl ester transfer protein inhibition. Endocrinology. 2009 May;150(5):2211-9. [3]. Barter PJ, et al. Effects of torcetrapib in patients at high risk for coronary events. N Engl J Med. 2007 Nov 22;357(21):2109-22. [4]. Morehouse LA, et al. Inhibition of CETP activity by torcetrapib reduces susceptibility to diet-induced atherosclerosis in New Zealand White rabbits. J Lipid Res. 2007 Jun;48(6):1263-72.

描述

Torcetrapib(CP-529414)是CETP高效抑制剂,IC50值为37nM。

相关类别

信号通路 >> 代谢酶/蛋白酶 >> CETP

研究领域 >> 内分泌

参考文献

[1]. Clark RW, et al. Raising high-density lipoprotein in humans through inhibition of cholesteryl ester transfer protein: an initial multidose study of torcetrapib. Arterioscler Thromb Vasc Biol. 2004 Mar;24(3):490-7.

[2]. Hu X, et al. Torcetrapib induces aldosterone and cortisol production by an intracellular calcium-mediated mechanism independently of cholesteryl ester transfer protein inhibition. Endocrinology. 2009 May;150(5):2211-9.

[3]. Barter PJ, et al. Effects of torcetrapib in patients at high risk for coronary events. N Engl J Med. 2007 Nov 22;357(21):2109-22.

[4]. Morehouse LA, et al. Inhibition of CETP activity by torcetrapib reduces susceptibility to diet-induced atherosclerosis in New Zealand White rabbits. J Lipid Res. 2007 Jun;48(6):1263-72.

密度	1.4±0.1 g/cm3
沸点	504.8±50.0 °C at 760 mmHg
熔点	54-58ºC
分子式	C₂₆H₂₅F₉N₂O₄
分子量	600.47
闪点	259.1±30.1 °C
PSA	59.08000
LogP	7.76
InChIKey	CMSGWTNRGKRWGS-NQIIRXRSSA-N
SMILES	CCOC(=O)N1c2ccc(C(F)(F)F)cc2C(N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)OC)CC1CC
外观性状	液体
蒸汽压	0.0±1.3 mmHg at 25°C
折射率	1.512
储存条件	Store at RT

符号	GHS07
信号词	Warning
危害声明	H302
危害码 (欧洲)	Xn
风险声明 (欧洲)	22
危险品运输编码	NONH for all modes of transport

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托彻普下游产品 0

Cholesteryl ester-transfer protein inhibitors stimulate aldosterone biosynthesis in adipocytes through Nox-dependent processes.

J. Pharmacol. Exp. Ther. 353(1) , 27-34, (2015)

Hyperaldosteronism and hypertension were unexpected side effects observed in trials of torcetrapib, a cholesteryl ester-transfer protein (CETP) inhibitor that increases high-density lipoprotein. Given...

Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients.

BMJ 349 , g4379, (2014)

To investigate the effects on cardiovascular outcomes of drug interventions that increase high density lipoprotein levels.Meta-analysis.Therapeutic benefit of niacin, fibrates, and cholesteryl ester t...

Identification of a novel, non-tetrahydroquinoline variant of the cholesteryl ester transfer protein (CETP) inhibitor torcetrapib, with improved aqueous solubility.

Xenobiotica 44(7) , 591-605, (2014)

1. Elaborate studies of cholesteryl ester transfer protein (CETP) polymorphisms and genetic deficiency in humans suggest direct links between CETP, high-density lipoprotein cholesterol (HDL-c) levels ...

Torcetrapib

Ethyl (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl](methoxycarbonyl)amino}-2-ethyl-6-(trifluoromethyl)-3,4-dihydro-1(2H)-quinolinecarboxylate

MFCD08063631

Ethyl (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl](methoxycarbonyl)amino}-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H)-carboxylate

ethyl (2R,4S)-4-[[3,5-bis(trifluoromethyl)phenyl]methyl-methoxycarbonylamino]-2-ethyl-6-(trifluoromethyl)-3,4-dihydro-2H-quinoline-1-carboxylate