托彻普

更新时间:2024-01-02 15:18:36

托彻普结构式
托彻普结构式
品牌特惠专场
常用名 托彻普 英文名 Torcetrapib
CAS号 262352-17-0 分子量 600.47
密度 1.4±0.1 g/cm3 沸点 504.8±50.0 °C at 760 mmHg
分子式 C26H25F9N2O4 熔点 54-58ºC
MSDS 中文版 美版 闪点 259.1±30.1 °C
符号 GHS07
GHS07
信号词 Warning

 托彻普用途


Torcetrapib(CP-529414)是CETP高效抑制剂,IC50值为37nM。

 托彻普名称

中文名 托彻普
英文名 torcetrapib
中文别名 (2R,4S)-4-[(3,5-双三氟甲基苄基)甲氧基甲酰氨基]-2-乙基-6-三氟甲基-3,4-二氢-2H-喹啉-1-羧酸乙酯
英文别名 更多

 托彻普物理化学性质

密度 1.4±0.1 g/cm3
沸点 504.8±50.0 °C at 760 mmHg
熔点 54-58ºC
分子式 C26H25F9N2O4
分子量 600.47
闪点 259.1±30.1 °C
PSA 59.08000
LogP 7.76
外观性状 液体
蒸汽压 0.0±1.3 mmHg at 25°C
折射率 1.512
储存条件 Store at RT

 托彻普安全信息

符号 GHS07
GHS07
信号词 Warning
危害声明 H302
危害码 (欧洲) Xn
风险声明 (欧洲) 22
危险品运输编码 NONH for all modes of transport

 托彻普合成线路

 托彻普文献39

更多文献
Cholesteryl ester-transfer protein inhibitors stimulate aldosterone biosynthesis in adipocytes through Nox-dependent processes.

J. Pharmacol. Exp. Ther. 353(1) , 27-34, (2015)

Hyperaldosteronism and hypertension were unexpected side effects observed in trials of torcetrapib, a cholesteryl ester-transfer protein (CETP) inhibitor that increases high-density lipoprotein. Given...

Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients.

BMJ 349 , g4379, (2014)

To investigate the effects on cardiovascular outcomes of drug interventions that increase high density lipoprotein levels.Meta-analysis.Therapeutic benefit of niacin, fibrates, and cholesteryl ester t...

Identification of a novel, non-tetrahydroquinoline variant of the cholesteryl ester transfer protein (CETP) inhibitor torcetrapib, with improved aqueous solubility.

Xenobiotica 44(7) , 591-605, (2014)

1. Elaborate studies of cholesteryl ester transfer protein (CETP) polymorphisms and genetic deficiency in humans suggest direct links between CETP, high-density lipoprotein cholesterol (HDL-c) levels ...

 托彻普英文别名

1(2H)-Quinolinecarboxylic acid, 4-[[[3,5-bis(trifluoromethyl)phenyl]methyl](methoxycarbonyl)amino]-2-ethyl-3,4-dihydro-6-(trifluoromethyl)-, ethyl ester, (2R,4S)-
Torcetrapib
Ethyl (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl](methoxycarbonyl)amino}-2-ethyl-6-(trifluoromethyl)-3,4-dihydro-1(2H)-quinolinecarboxylate
MFCD08063631
Ethyl (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl](methoxycarbonyl)amino}-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H)-carboxylate
ethyl (2R,4S)-4-[[3,5-bis(trifluoromethyl)phenyl]methyl-methoxycarbonylamino]-2-ethyl-6-(trifluoromethyl)-3,4-dihydro-2H-quinoline-1-carboxylate
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