84878-61-5

• 常用中文名：马度米星
• 常用英文名：Maduramicin ammonium
• CAS号：84878-61-5
• 分子式：C₄₇H₈₃NO₁₇
• 分子量：934.158
• 相关类别： 原料药 抗寄生虫病药 抗原虫药
• 发布时间：2018-07-19 12:01:46
• 更新时间：2026-07-02 11:26:44
• Maduramicin ammonium (Maduramycin ammonium) 是从放线菌 Actinomadura rubra 中分离出来的。 Maduramicin ammonium (Maduramycin ammonium) 是一种抗球虫药,用于治疗艾美耳球菌,腺苷球菌,鸡血肠球菌和分散肠球菌感染。Maduramicin ammonium (Maduramycin ammonium) 通过内在和外在途径诱导鸡心肌细胞凋亡 (apoptosis)。

名称

• 中文名: 马杜霉素铵盐
• 英文名: Maduramicin
• 中文别名: 马度米星铵盐; 马度米星铵原料药; 马杜拉霉素; 马杜米星铵; 马杜霉素铵盐. 标准品; 2-((2R,3S,4S,5R,6S)-6-((R)-1-((2S,5R,7S,8R,9S)-2-((2S,2'R,3'S,5R,5'R)-3'-(((2R,4S,5S,6S)-4,5-二甲氧基-6-甲基四氢-2H-吡喃-2-基)氧基)-5'-((2S,3S,5R,6S)-6-羟基-3,5,6-三甲基四氢-2H-吡喃-2-基)-2-甲基八氢-[2,2'-二呋喃]-5-基)-9-羟基- 2,8-二甲基-1,6-二氧杂螺癸七-7-基)乙基)-2-羟基-4,5-二甲氧基-3-甲基四氢-2H-吡喃-2-基)乙酸铵; 马杜米星铵盐预混剂; 克球皇; 马度米星铵(马杜拉霉素); 马度米星铵·尼卡巴嗪预混剂; 马度米星铵; 马杜霉素铵精品; 马杜拉霉素/马度米星胺; 加福(CRO); 马杜霉素铵盐( 马度米星); 马杜霉素铵,马度米星铵,克球皇; 马杜霉素铵标准品; 甲醇中马杜霉素铵盐; 马度米星铵/马杜拉霉素/克球皇; 马杜霉素铵盐,10 MM DMSO 溶液; 马杜拉霉素铵; 杜球; 甲醇中马杜霉素铵盐溶液标准物质; 2-((2R,3S,4S,5R,6S)-6-((R)-1-((2S,5R,7S,8R,9S)-2-((2S,2'R,3'S,5R,5'R)-3'-(((2R,4S,5S,6S)-4,5-二甲氧基-6-甲基四氢-2H-吡喃-2-基)氧基)-5'-((2S,3S,5R,6S)-6-羟基-3,5,6-三甲基四氢-2H-吡喃-2-基)-2-甲基八氢-[2,2'-二呋喃]-5-基)-9-羟基- 2,8-二甲基-1,6-二氧杂螺癸七-7-基)乙基)-2-羟基-4,5-二甲氧基-3-甲基四氢-2H; 2-((2R,3S,4S,5R,6S)-6-((R)-1-((2S,5R,7S,8R,9S)-2-((2S,2'R,3'S,5R,5'R)-3'-(((2R,4S,5S,6S)-4,5-二甲氧基-6-甲基四氢-2H-吡喃-2-基)氧基)-5'-((2S,3S,5R,6S)-6-羟基-3,5,6-三甲基四氢-2H-吡喃-2-基)-2-甲基八氢-[2,2'-二呋喃]-5-基)-9-羟基- 2,8-二甲基-1,6-二氧杂螺癸七-7-基)乙基)-2-羟基-4,5-二甲氧基-3-甲基四氢-2H-吡喃-2; Maduramicin ammonium salt 2003 类白色结晶; 杜球(马杜霉素预混剂); 马杜霉素铵; 甲醇中马度米星铵溶液标准物质; 马度米星铵 抗寄生虫病药; 马杜霉素铵盐溶液, 100PPM
• 英文别名: MADURAMICIN AMMONIUM; Maduramicin a, Monoammonium Salt; Maduramycin ammonium on corn cob; MADURAMICIN AMMONIUM SALT; MADURAMINIC AMMONIUM; Maduramycin ammonium; Madubamycin ammonium; Decocci (Maduramcin ammonium premix); Maduraminic Ammonium; Cyo; TIANFUCHEM-84-5--Maduramycin ammonium; Maduramicin ammonium premix; MADURAMYCIN AMMONIUM; Prinicin ammonium; Ammonium 2-((2R,3S,4S,5R,6S)-6-((R)-1-((2S,5R,7S,8R,9S)-2-((2S,2'R,3'S,5R,5'R)-3'-(((2R,4S,5S,6S)-4,5-dimethoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-5'-((2S,3S,5R,6S)-6-hydroxy-3,5,6-trimethyltetrahydro-2H-pyran-2-yl)-2-methyloctahydro-[2,2'-bifuran]-5-y; (2R,3S,4S,5R,6S)-6-[(1R)-1-[(2S,5R,7S,8R,9S)-2-[(2S,2'R,3'S,5R,5'R)-3'-[(2,6-Dideoxy-3,4-di-O-methyl-b-L-abino-hexopyranosyl)oxy]octahydro-2-methyl-5'-[(2S,3S,5R,6S)-tetrahydro-6-hydroxy-3,5,6-trimethyl-2H-pyran-2-yl][2,2'-bifuran]-5-yl]-9-hydroxy-2,8-dimethyl-1,6-dioxaspirodec-7-yl]ethyl]tetrahydro-2-hydroxy-4,5-dimethoxy-3-methyl-2H-pyran-2-acetic acid monoammonium salt; [(2R,3S,4S,5R,6S)-6-{(1R)-1-[(2S,5R,7S,8R,9S)-2-{(2S,2'R,3'S,5R,5'R)-3'-{[(2R,4S,5S,6S)-4,5-Dimethoxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-5'-[(2S,3S,5R,6S)-6-hydroxy-3,5,6-trimethyltetrahydro-2H-pyran-2-yl]-2-methyloctahydro-2,2'-bifuran-5-yl}-9-hydroxy-2,8-dimethyl-1,6-dioxaspiro[4.5]dec-7-yl]ethyl}-2-hydroxy-4,5-dimethoxy-3-methyltetrahydro-2H-pyran-2-yl]acetic acid ammoniate (1:1) (non-preferred name); Madumixing ammonium; CA14670000 Maduramicin ammonium; MADURAMICINAMMONIUM; maduramycin ammonium premix; Maduramycin; MADURAMICIN AMMONIUM PREMIX; Ammonium 2-((2R,3S,4S,5R,6S)-6-((R)-1-((2S,5R,7S,8R,9S)-2-((2S,2'R,3'S,5R,5'R)-3'-(((2R,4S,5S,6S)-4,5-dimethoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-5'-((2S,3S,5R,6S)-6-hydroxy-3,5,6-trimethyltetrahydro-2H-pyran-2-yl)-2-methyloctahydro-[2,2'-bifuran]-5-yl)-9-hydroxy-2,8-dimethyl-1,6-dioxaspirodecan-7-yl)ethyl)-2-hydroxy-4,5-dimethoxy-3-methyltetrahydro-2H-pyran-2-yl)acetate; Maduramicin ammonium, 10 mM in DMSO; CL 259971, MaduraMycin sodiuM; 2H-Pyran-2-acetic acid, 6-(1R)-1-(2S,5R,7S,8R,9S)-2-(2S,2R,3S,5R,5R)-3-(2,6-dideoxy-3,4-di-O-methyl-.beta.-L-abino-hexopyranosyl)oxyoctahydro-2-methyl-5-(2S,3S,5R,6S)-tetrahydro-6-hydroxy-3,5,6-trimethyl-2H-pyran-2-yl2,2-bifuran-5-yl-9-hydroxy-2,8-dimet; Maduramycin ammonium //BP; MaduraMicin α, MonoaMMoniuM Salt; MADUBAMYCIN AMMONIUM; princin ammonoum; Maduramincin ammonium; MaduraMicin AMMoniuM PreMix //BP; Maduramicin Ammonium Standd; Maduramycin ammonium salt; MaduraMycin HOUSE STANDD; Maduramicin ammoniumQ: What is Maduramicin ammonium Q: What is the CAS Number of Maduramicin ammonium Q: What is the storage condition of Maduramicin ammonium Q: What e the applications of Maduramicin ammonium; maduramicin ammonoium

物化性质

• 沸点: 913.9ºC at 760 mmHg
• 熔点: 173-176ºC
• 分子式: C₄₇H₈₃NO₁₇
• 分子量: 934.158
• 闪点: 255.5ºC
• 精确质量: 933.566101
• PSA: 211.58000
• LogP: 3.35840
• 储存条件: 0-6°C

生物活性

• 描述: Maduramicin ammonium (Maduramycin ammonium) 是从放线菌 Actinomadura rubra 中分离出来的。 Maduramicin ammonium (Maduramycin ammonium) 是一种抗球虫药,用于治疗艾美耳球菌,腺苷球菌,鸡血肠球菌和分散肠球菌感染。Maduramicin ammonium (Maduramycin ammonium) 通过内在和外在途径诱导鸡心肌细胞凋亡 (apoptosis)。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 靶点:

  IC50: bacterial; apoptosis[1]

• 参考文献:

  [1]. McDougald LR, et al. Efficacy of maduramicin ammonium against coccidiosis in turkeys under laboratory and floor-pen conditions.Avian Dis. 1990 Jul-Sep;34(3):634-8.

  [2]. Gao X, et al.Maduramicin induces apoptosis in chicken myocardial cells via intrinsic and extrinsic pathways.Toxicol In Vitro. 2018 Aug;50:190-200.

安全

• 符号: GHS06
• 信号词: Danger
• 危害声明: H300 + H310-H319
• 警示性声明: Missing Phrase - N15.00950417-P262-P280-P302 + P352 + P310-P305 + P351 + P338-P361 + P364
• 个人防护装备: Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
• 危害码 (欧洲): T+:Verytoxic;
• 风险声明 (欧洲): R25;R27;R36
• 安全声明 (欧洲): S26-S28-S36/37-S45
• 危险品运输编码: UN 2811
• 包装等级: III
• 危险类别: 6.1