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64925-80-0

64925-80-0结构式
64925-80-0结构式
  • 常用中文名:Phomopsin A
  • 常用英文名:Phomopsin A
  • CAS号:64925-80-0
  • 分子式:C36H45ClN6O12
  • 分子量:789.22800
  • 相关类别: 信号通路 细胞周期/DNA损伤 微管/微管蛋白
  • 发布时间:2016-08-27 00:06:56
  • 更新时间:2024-01-08 18:00:39
  • Phomopsin A 是一种从真菌 Phomopsis leptostomiformis 分离的环状六肽霉菌毒素。Phomopsin A 是放射性标记的长春新碱与微管蛋白结合的非竞争性抑制剂。

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中文名 噬菌素A
英文名 phomopsin a
英文别名 phomopsin a from phomopsis leptostromiformis
phomopsin
PMSA
描述 Phomopsin A 是一种从真菌 Phomopsis leptostomiformis 分离的环状六肽霉菌毒素。Phomopsin A 是放射性标记的长春新碱与微管蛋白结合的非竞争性抑制剂。
相关类别
参考文献

[1]. Hamel E, et al. Natural products which interact with tubulin in the vinca domain: maytansine, rhizoxin, phomopsin A, dolastatins 10 and 15 and halichondrin B. Pharmacol Ther. 1992;55(1):31-51.

密度 1.48g/cm3
沸点 1188.2ºC at 760 mmHg
分子式 C36H45ClN6O12
分子量 789.22800
闪点 672.4ºC
精确质量 788.27800
PSA 273.03000
LogP 2.27850
折射率 1.655
储存条件 2-8°C,密封,干燥

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SY2593000
CHEMICAL NAME :
Phomopsin A
CAS REGISTRY NUMBER :
64925-80-0
LAST UPDATED :
199801

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Mammal - domestic
DOSE/DURATION :
10 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Mammal - domestic
DOSE/DURATION :
1 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Mammal - domestic
DOSE/DURATION :
1 mg/kg/1W-I
TOXIC EFFECTS :
Behavioral - food intake (animal) Liver - other changes Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Mammal - domestic
DOSE/DURATION :
1 mg/kg/4W-I
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Liver - jaundice (or hyperbilirubinemia) hepatocellular
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
150 ug/kg
SEX/DURATION :
female 6-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
400 ug/kg
SEX/DURATION :
female 6 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
10 mg/L
REFERENCE :
CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969- Volume(issue)/page/year: 46,79,1986

危害码 (欧洲) Xn: Harmful;
风险声明 (欧洲) 20/21/22-40