77-38-3

• 常用中文名：氯苯沙明
• 常用英文名：Chlorphenoxamine
• CAS号：77-38-3
• 分子式：C₁₈H₂₂ClNO
• 分子量：303.82600
• 相关类别： 香精与香料 合成香料 羧酸及酯类香料 芳香族羧酸酯
• 发布时间：2018-07-14 22:10:23
• 更新时间：2026-07-15 15:13:33
• Chlorphenoxamine是一种抗组胺剂和抗胆碱能药, 用作抗帕金森氏病。

名称

• 中文名: 氯苯沙明
• 英文名: 2-[1-(4-chlorophenyl)-1-phenylethoxy]-N,N-dimethylethanamine
• 中文别名: 2-(1-(4-氯苯基)-1-苯基乙氧基)-N,N-二甲基乙胺; 2-(1-(4-氯苯基)-1-苯乙氧基)-N,N-二甲基乙-1-胺; 氯苯沙明标准品
• 英文别名: beta-Dimethylamino-aethyl-(p-chlor-alpha-methylbenzhydryl)-aether; p-Chlor-alpha-methyl-diphenhydramin; 2-[1-(p-Chlorophenyl)-1-phenylethoxy]-N,N-dimethylethanamine; RMA-351; 2-(1-(4-Chlorophenyl)-1-phenylethoxy)-N,N-dimethylethanamine; {2-[1-(4-Chlor-phenyl)-1-phenyl-aethoxy]-aethyl}-dimethyl-amin; Ethylamine, 2-[1-(p-chlorophenyl)-1-phenylethoxy]-N,N-dimethyl; Clorfenossamina [DCIT]; 2-(1-(p-Chlorophenyl)-1-phenylethoxy)-N,N-dimethylethylamine; CHLORPHENOXAMINE; Chlorphenoxamine [INN:BAN]; Chlorphenoxaminum [INN-Latin]; EthanaMine, 2-[1-(4-chlorophenyl)-1-phenylethoxy]-N,N-diMethyl; Contristamine; 2-[1-(4-Chlorophenyl)-1-phenylethoxy]-N,N-dimethylethan-1-amine; β-Dimethylaminoethyl(p-chloro-α-methylbenzhydryl)ether; N-(2-(1-p-chlorophenyl-1-phenylethoxy)ethyl)dimethylamine; {2-[1-(4-chloro-phenyl)-1-phenyl-ethoxy]-ethyl}-dimethyl-amine; Inhibitor,Histamine Rector,Chlorphenoxamine,inhibit; Clorfenoxamina [INN-Spanish]; 1-(4-Chlorophenyl)-1-[2-(dimethylamino)ethoxy]-1-phenylethane; 2-[1-(4-Chlorophenyl)-1-phenylethoxy]-N,N-dimethylethanamine

物化性质

• 密度: 1.093g/cm3
• 沸点: 383.7ºC at 760 mmHg
• 分子式: C₁₈H₂₂ClNO
• 分子量: 303.82600
• 闪点: 185.9ºC
• 精确质量: 303.13900
• PSA: 12.47000
• LogP: 4.18170
• 折射率: 1.551
• 储存条件: 2-8°C

生物活性

• 描述: Chlorphenoxamine是一种抗组胺剂和抗胆碱能药, 用作抗帕金森氏病。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体
  信号通路 >> 免疫及炎症 >> 组胺受体
  研究领域 >> 神经疾病

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : KR3185000 CHEMICAL NAME : Ethylamine, 2-(1-(p-chlorophenyl)-1-phenylethoxy)-N,N-dimethyl- CAS REGISTRY NUMBER : 77-38-3 BEILSTEIN REFERENCE NO. : 2057618 LAST UPDATED : 199709 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C18-H22-Cl-N-O MOLECULAR WEIGHT : 303.86 WISWESSER LINE NOTATION : GR DX1&R&O2N1&1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 376 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,237,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 167 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,237,1957

安全

• 危害码 (欧洲): Xi
• 海关编码: 2922199090

合成路线

122-01-0 ~% 77-38-3

文献：Tetrahedron Letters, , vol. 29, # 30 p. 3659 - 3662

591-51-5 ~% 77-38-3

文献：Tetrahedron Letters, , vol. 29, # 30 p. 3659 - 3662

134-85-0 ~% 77-38-3

文献：Tetrahedron Letters, , vol. 29, # 30 p. 3659 - 3662

59767-24-7 107-99-3 ~% 77-38-3

文献：Tetrahedron Letters, , vol. 29, # 30 p. 3659 - 3662

107-99-3 ~% 77-38-3

文献：DE952715 , ; Collection of Czechoslovak Chemical Communications, , vol. 24, p. 3966,3974

上下游产品

上游产品  5
122-01-0 591-51-5 134-85-0 59767-24-7
107-99-3
下游产品  0

海关

海关编码	2922199090
中文概述	2922199090. 其他氨基醇及其醚，酯和它们的盐（但含一种以上含氧基的除外）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
Summary	2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%