409351-28-6

409351-28-6结构式

中文名	3-氨基-N-[(4-甲氧基苯基)甲基]-4,6-二甲基噻吩并[2,3-B]吡啶-2-甲酰胺
英文名	3-amino-N-[(4-methoxyphenyl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide
中文别名	VU0152100,M 4正变构调节剂 3-氨基-N-(4-甲氧基苄基)-4,6-二甲基噻吩并[2,3-B]吡啶-2-甲酰胺
英文别名	Kinome_1269 3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridinecboxamide VU-152100,Inhibitor,Muscinic acetylcholine rector,inhibit,VU0152100,VU 152100,mAChR,VU-0152100,VU 3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridine-2-cboxamide VU0152100, M4 positive allosteric modulator VU0152100, 10 mM in DMSO VU152100;VU 0152100;VU-0152100 3-Amino-N-[(4-methoxyphenyl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-cboxamide ML108 Thieno[2,3-b]pyridine-2-cboxamide, 3-amino-N-[(4-methoxyphenyl)methyl]-4,6-dimethyl 3-Amino-N-[(4-methoxyphenyl)methyl]-4,6-dimethyl-thieno[2,3-b]pyridine-2-carboxamide

描述	VU0152100是M4 mAChR的变构增强剂,EC50为380 nM。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR 信号通路 >> 神经信号通路 >> mAChR 研究领域 >> 神经疾病
参考文献	[1]. Brady AE, et al. Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats. J Pharmacol Exp Ther. 2008 Dec;327(3):941-53.