3-氨基-N-[(4-甲氧基苯基)甲基]-4,6-二甲基噻吩并[2,3-B]吡啶-2-甲酰胺

更新时间：2025-09-11 20:47:10

3-氨基-N-[(4-甲氧基苯基)甲基]-4,6-二甲基噻吩并[2,3-B]吡啶-2-甲酰胺结构式	常用名	3-氨基-N-[(4-甲氧基苯基)甲基]-4,6-二甲基噻吩并[2,3-B]吡啶-2-甲酰胺	英文名	VU0152100
	CAS号	409351-28-6	分子量	341.42700
	密度	N/A	沸点	N/A
	分子式	C₁₈H₁₉N₃O₂S	熔点	N/A
	MSDS	中文版美版	闪点	N/A
	符号	GHS06	信号词	Danger

用途

VU0152100是M4 mAChR的变构增强剂，EC50为380 nM。

中文名	3-氨基-N-[(4-甲氧基苯基)甲基]-4,6-二甲基噻吩并[2,3-B]吡啶-2-甲酰胺
英文名	3-amino-N-[(4-methoxyphenyl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide
英文别名	更多

描述	VU0152100是M4 mAChR的变构增强剂,EC50为380 nM。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR 信号通路 >> 神经信号通路 >> mAChR 研究领域 >> 神经疾病
参考文献	[1]. Brady AE, et al. Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats. J Pharmacol Exp Ther. 2008 Dec;327(3):941-53.

分子式	C₁₈H₁₉N₃O₂S
分子量	341.42700
精确质量	341.12000
PSA	105.48000
LogP	4.40600
InChIKey	MDNWGCQSCGNTKH-UHFFFAOYSA-N
SMILES	COc1ccc(CNC(=O)c2sc3nc(C)cc(C)c3c2N)cc1
储存条件	2-8℃

符号	GHS06
信号词	Danger
危害声明	H301-H319
警示性声明	P301 + P310-P305 + P351 + P338
危险品运输编码	UN 2811 6.1 / PGIII

Regulation of synaptic MAPK/ERK phosphorylation in the rat striatum and medial prefrontal cortex by dopamine and muscarinic acetylcholine receptors.

J. Neurosci. Res. 93 , 1592-9, (2015)

Dopamine and acetylcholine are two principal transmitters in the striatum and are usually balanced to modulate local neural activity and to maintain striatal homeostasis. This study investigates the r...

Investigation of the presence and antinociceptive function of muscarinic acetylcholine receptors in the African naked mole-rat (Heterocephalus glaber).

J. Comp. Physiol. A. Neuroethol. Sens. Neural. Behav. Physiol. 202 , 7-15, (2016)

The present study investigated the cholinergic system in the African naked mole-rat (Heterocephalus glaber) with focus on the muscarinic acetylcholine receptor subtypes M1 and M4. The protein sequence...

Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodents.

ACS Chem. Neurosci. 5(10) , 920-42, (2014)

Positive allosteric modulators (PAMs) of the M4 muscarinic acetylcholine receptor (mAChR) represent a novel approach for the treatment of psychotic symptoms associated with schizophrenia and other neu...

实验名称：Ratio of total drug level in brain to plasma (unknown origin)
来源：ChEMBL
靶标：N/A
External Id：CHEMBL3874735

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来源：NCGC
靶标：N/A
External Id：ADME-solubility1

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来源：NCGC
External Id：IP6K1-p1

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来源：ChEMBL
靶标：N/A
External Id：CHEMBL3874731

实验名称：Clearance in human hepatocytes
来源：ChEMBL
靶标：N/A
External Id：CHEMBL3874732

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来源：ChEMBL
靶标：Muscarinic acetylcholine receptor M4
External Id：CHEMBL5030006

实验名称：Fraction unbound in human
来源：ChEMBL
靶标：N/A
External Id：CHEMBL3874734

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来源：NCGC
External Id：CYP3A4437

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来源：NCGC
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来源：NCGC
External Id：CYP2C9536

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