286930-03-8

• 常用中文名：富马酸非索罗定
• 常用英文名：Fesoterodine Fumarate
• CAS号：286930-03-8
• 分子式：C₃₀H₄₁NO₇
• 分子量：527.649
• 相关类别： 生物化工 抑制剂 神经信号通路(Neuronal Signaling) AChR 拮抗剂
• 发布时间：2018-07-12 03:51:53
• 更新时间：2024-01-02 15:19:05

名称

• 中文名: 富马酸非索罗定
• 英文名: (E)-but-2-enedioic acid,[2-[(1R)-3-[di(propan-2-yl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenyl] 2-methylpropanoate
• 中文别名: 非索罗定
• 英文别名: (R)-Fesoterodine fumarate; Fesoterodine Fumarate; UNII-EOS72165S7; SPM 8272; SPM 907; Propanoic acid, 2-methyl-, 2-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenyl ester, (2E)-2-butenedioate (1:1); Toviaz,Fesoterodine fumarate; 2-[(1R)-3-(Diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenyl 2-methylpropanoate (2E)-2-butenedioate (1:1); Propanoic acid,2-methyl-,2-((1R)-3-(bis(1-methylethyl)amino)-1-phenylpropyl)-4-(hydroxymethyl)phenyl ester,(2E)-2-butenedioate (1:1) (salt); Fesoterodinefumarate; Toviaz; (R)-2-(3-(Diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenyl isobutyrate fumarate; Fesoterodine (fumarate)

物化性质

• 沸点: 518.9ºC at 760 mmHg
• 熔点: 72-78ºC
• 分子式: C₃₀H₄₁NO₇
• 分子量: 527.649
• 闪点: 267.6ºC
• 精确质量: 527.288330
• PSA: 124.37000
• LogP: 5.09290
• 外观性状: 白色固体
• 储存条件: Hygroscopic, Store under Inert atmosphere -20°C Freezer

生物活性

• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR
  信号通路 >> 神经信号通路 >> mAChR
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Staskin David; Khullar Vik; Michel Martin C et al. Effects of voluntary dose escalation in a placebo-controlled, flexible-dose trial of fesoterodine in subjects with overactive bladder. Neurourology and urodynamics (2011), 30(8), 1480-5.

  [2]. Vella Maria; Cardozo Linda Review of fesoterodine. Expert opinion on drug safety (2011), 10(5), 805-8.

  [3]. Malhotra Bimal; Alvey Christine; Gong Jason et al. Effects of fesoterodine on the pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers. British journal of clinical pharmacology (2011), 72(2), 257-62.

  [4]. Michel MC. Fesoterodine: a novel muscarinic receptor antagonist for the treatment of overactive bladder syndrome. Expert Opin Pharmacother. 2008 Jul;9(10):1787-96.

  [5]. Fesoterodine