992-21-2

• 常用中文名：四环素亚甲赖氨酸
• 常用英文名：Lymecycline
• CAS号：992-21-2
• 分子式：C₂₉H₃₈N₄O₁₀
• 分子量：602.63
• 相关类别： 原料药 抗生素类药物 四环素类药
• 发布时间：2018-08-08 19:28:55
• 更新时间：2026-07-16 09:28:24
• Lymecycline 是四环素衍生物,具有广谱的抗菌活性,同时具有抗炎活性。

名称

• 中文名: 赖甲环素
• 英文名: lymecycline
• 中文别名: 莱美环素; 赖甲四环素; 莱姆环素
• 英文别名: Limeciclina; myl; (S)-2-amino-6-((((4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-cboxamido)methyl)amino)hexanoic acid; Mucomycin; Tertamyl; Tetracyclinemethylene lysine; Tetracycline-L-methylenelysine; L-Lysine, N6-[[[[(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenyl]carbonyl]amino]methyl]; 2,3-Dihydroxy-2-(1-methylethyl)-butanoic acid (2,3,5,7a-tetrahydro-1-hydroxy-1H-pyrrolizin-7-yl) methyl ester; N-lysinomethyltetracycline; Tetralysal; N6-[[(4S)-4β-(Dimethylamino)-1,4,4aβ,5,5aβ,6,11,12a-octahydro-3,6α,10,12,12aβ-pentahydroxy-6-methyl-1,11-dioxonaphthacen-2-yl]cbonylaminomethyl]-L-lysine; Vebicyclysal; Tetramyl; Tetracycline impurity 20; limecycline; lycopsamine; (+)-N-(5-Amino-5-cboxypentylaminomethyl)-4-dimethylamino-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxonaphthacene-2-cboxamide; lymecycline //BP; (+)-Indicine; Tetralisal; [(1r,7ar)-1-hydroxy-2,3,5,7a-tetrahydro-1h-pyrrolizin-7-yl]methyl(2r,3s)-2,3-dihydroxy-2-isopropylbutanoate

物化性质

• 密度: 1.53
• 沸点: 840.5ºC at 760 mmHg
• 熔点: 192.5°C
• 分子式: C₂₉H₃₈N₄O₁₀
• 分子量: 602.63
• 闪点: 462.1ºC
• 精确质量: 602.25900
• PSA: 242.98000
• LogP: 1.02790
• 折射率: 1.693
• 水溶解性: Very soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.

生物活性

• 描述: Lymecycline 是四环素衍生物,具有广谱的抗菌活性,同时具有抗炎活性。
• 相关类别:
  研究领域 >> 感染
  研究领域 >> 炎症/免疫
  信号通路 >> 抗感染 >> 细菌
• 靶点:

  Bacterial[1]

• 体外研究: 利美环素是一种四环素衍生物,具有广谱抗菌活性,可干扰核糖体水平的原核蛋白合成。利美环素还具有抗炎特性[1]。
• 参考文献:

  [1]. Rempe S, et al. Tetracyclines and pulmonary inflammation. Endocr Metab Immune Disord Drug Targets. 2007 Dec;7(4):232-6.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : OL5615000 CHEMICAL NAME : Lysine, N(sup 6)-((4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro -3,6,10,12,12a- pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxa mido)methyl)-, (+)- CAS REGISTRY NUMBER : 992-21-2 LAST UPDATED : 199201 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C29-H38-N4-O10 MOLECULAR WEIGHT : 602.71 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 181 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,333,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : 253 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 2,106,1964