24769-56-0

• 常用中文名：tetranor-PGEM
• 常用英文名：tetranor-PGEM (tetranor-Prostaglandin E Metabolite)
• CAS号：24769-56-0
• 分子式：C₁₆H₂₄O₇
• 分子量：328.358
• 相关类别： 研究领域 癌症
• 发布时间：2016-07-08 17:09:32
• 更新时间：2024-01-04 12:45:29
• 前列腺素E-M是前列腺素E2(PEG2)的代谢产物,是炎症和癌症的生物标志物,包括晚期结直肠癌、卵巢癌、前列腺癌等。尿中前列腺素E-M与肥胖、吸烟和乳腺癌肺转移呈正相关[1][2][3]。

名称

• 中文名: tetranor-PGEM
• 英文名: 9,15-dioxo-11alpha-hydroxy-2,3,4,5-tetranor-prostan-1,20-dioic acid
• 英文别名: 8-[(1R,2R,5R)-2-(2-Carboxyethyl)-5-hydroxy-3-oxocyclopentyl]-6-oxooctanoic acid; Cyclopentaneoctanoic acid, 2-(2-carboxyethyl)-5-hydroxy-η,3-dioxo-, (1R,2R,5R)-; 11alpha-hydroxy-9,15-dioxo-2,3,4,5,20-pentanor-19-carboxyprostanoicacid; 8-[(1R,2R,5R)-2-(2-Carboxyethyl)-5-hydroxy-3-oxocyclopentyl]-8-oxooctanoic acid; TETRANOR-PGEM; tetranor-prostaglandin E metabolite; Cyclopentaneoctanoic acid, 2-(2-carboxyethyl)-5-hydroxy-ε,3-dioxo-, (1R,2R,5R)-; tetranor-PGEM Lipid Maps MS Standard

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 622.4±55.0 °C at 760 mmHg
• 分子式: C₁₆H₂₄O₇
• 分子量: 328.358
• 闪点: 344.2±28.0 °C
• 精确质量: 328.152191
• PSA: 128.97000
• LogP: -0.90
• 蒸汽压: 0.0±4.1 mmHg at 25°C
• 折射率: 1.529
• 储存条件: -20°C，密闭，干燥

生物活性

• 描述: 前列腺素E-M是前列腺素E2(PEG2)的代谢产物,是炎症和癌症的生物标志物,包括晚期结直肠癌、卵巢癌、前列腺癌等。尿中前列腺素E-M与肥胖、吸烟和乳腺癌肺转移呈正相关[1][2][3]。
• 相关类别:
  研究领域 >> 癌症
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Johnson JC, et al. Urine PGE-M: A metabolite of prostaglandin E2 as a potential biomarker of advanced colorectal neoplasia. Clin Gastroenterol Hepatol. 2006 Nov;4(11):1358-65.

  [2]. Wang D, DuBois RN. Urinary PGE-M: a promising cancer biomarker. Cancer Prev Res (Phila). 2013 Jun;6(6):507-10.

  [3]. Morris PG, et al. Increased levels of urinary PGE-M, a biomarker of inflammation, occur in association with obesity, aging, and lung metastases in patients with breast cancer. Cancer Prev Res (Phila). 2013 May;6(5):428-36.

安全

• 海关编码: 2918990090

海关

海关编码	2918990090
中文概述	2918990090. 其他含其他附加含氧基羧酸（包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%