tetranor-PGEM

更新时间：2026-08-01 18:20:19

tetranor-PGEM结构式	常用名	tetranor-PGEM	英文名	tetranor-PGEM (tetranor-Prostaglandin E Metabolite)
	CAS号	24769-56-0	分子量	328.358
	密度	1.3±0.1 g/cm3	沸点	622.4±55.0 °C at 760 mmHg
	分子式	C₁₆H₂₄O₇	熔点	N/A
	MSDS	N/A	闪点	344.2±28.0 °C

tetranor-PGEM用途

前列腺素E-M是前列腺素E2(PEG2)的代谢产物,是炎症和癌症的生物标志物,包括晚期结直肠癌、卵巢癌、前列腺癌等。尿中前列腺素E-M与肥胖、吸烟和乳腺癌肺转移呈正相关[1][2][3]。

中文名	tetranor-PGEM
英文名	9,15-dioxo-11alpha-hydroxy-2,3,4,5-tetranor-prostan-1,20-dioic acid
英文别名	更多

描述	前列腺素E-M是前列腺素E2(PEG2)的代谢产物,是炎症和癌症的生物标志物,包括晚期结直肠癌、卵巢癌、前列腺癌等。尿中前列腺素E-M与肥胖、吸烟和乳腺癌肺转移呈正相关[1][2][3]。
相关类别	研究领域 >> 癌症研究领域 >> 炎症/免疫
参考文献	[1]. Johnson JC, et al. Urine PGE-M: A metabolite of prostaglandin E2 as a potential biomarker of advanced colorectal neoplasia. Clin Gastroenterol Hepatol. 2006 Nov;4(11):1358-65. [2]. Wang D, DuBois RN. Urinary PGE-M: a promising cancer biomarker. Cancer Prev Res (Phila). 2013 Jun;6(6):507-10. [3]. Morris PG, et al. Increased levels of urinary PGE-M, a biomarker of inflammation, occur in association with obesity, aging, and lung metastases in patients with breast cancer. Cancer Prev Res (Phila). 2013 May;6(5):428-36.

描述

相关类别

研究领域 >> 癌症

研究领域 >> 炎症/免疫

参考文献

[1]. Johnson JC, et al. Urine PGE-M: A metabolite of prostaglandin E2 as a potential biomarker of advanced colorectal neoplasia. Clin Gastroenterol Hepatol. 2006 Nov;4(11):1358-65.

[2]. Wang D, DuBois RN. Urinary PGE-M: a promising cancer biomarker. Cancer Prev Res (Phila). 2013 Jun;6(6):507-10.

[3]. Morris PG, et al. Increased levels of urinary PGE-M, a biomarker of inflammation, occur in association with obesity, aging, and lung metastases in patients with breast cancer. Cancer Prev Res (Phila). 2013 May;6(5):428-36.

密度	1.3±0.1 g/cm3
沸点	622.4±55.0 °C at 760 mmHg
分子式	C₁₆H₂₄O₇
分子量	328.358
闪点	344.2±28.0 °C
精确质量	328.152191
PSA	128.97000
LogP	-0.90
InChIKey	ZJAZCYLYLVCSNH-JHJVBQTASA-N
SMILES	O=C(O)CCCCC(=O)CCC1C(O)CC(=O)C1CCC(=O)O
蒸汽压	0.0±4.1 mmHg at 25°C
折射率	1.529
储存条件	-20°C，密闭，干燥

海关编码	2918990090

海关编码	2918990090
中文概述	2918990090. 其他含其他附加含氧基羧酸（包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

实验名称：Cell-based high throughput primary assay to identify activators of GPR151
来源：The Scripps Research Institute Molecular Screening Center
靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL
External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of...
来源：The Scripps Research Institute Molecular Screening Center
External Id：MITF_INH_Alpha_1536_1X%INH PRUN

共2条，当前第1页，共1页

8-[(1R,2R,5R)-2-(2-Carboxyethyl)-5-hydroxy-3-oxocyclopentyl]-6-oxooctanoic acid

11alpha-hydroxy-9,15-dioxo-2,3,4,5,20-pentanor-19-carboxyprostanoicacid

8-[(1R,2R,5R)-2-(2-Carboxyethyl)-5-hydroxy-3-oxocyclopentyl]-8-oxooctanoic acid

TETRANOR-PGEM

tetranor-prostaglandin E metabolite

tetranor-PGEM Lipid Maps MS Standard