158876-82-5

• 常用中文名：芦帕他定
• 常用英文名：Rupatadine
• CAS号：158876-82-5
• 分子式：C₂₆H₂₆ClN₃
• 分子量：415.958
• 相关类别： 信号通路 自噬 自噬
• 发布时间：2018-03-07 08:00:00
• 更新时间：2024-01-05 12:50:14
• Rupatadine(UR-12592)是PAF/H1受体双效抑制剂，Ki值分别为0.55uM和0.1uM。

名称

• 中文名: 卢帕他定
• 英文名: 8-chloro-11-[1-[(5-methylpyridin-3-yl)methyl]piperidin-4-ylidene]-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridine
• 中文别名: 8-氯-6,11-二氢-11-[1-[(5-甲基-3-吡啶基)甲基]-4-哌啶亚基]-5H-苯并[5,6]环庚烷并[1,2-b]吡啶; 芦帕他定
• 英文别名: Rupatadine [INN]; 5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 8-chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)methyl]-4-piperidinylidene]-; 8-Chloro-6,11-dihydro-11-(1-((5-methyl-3-pyridinyl)methyl)-4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine; 8-Chloro-11-{1-[(5-methylpyridin-3-yl)methyl]piperidin-4-ylidene}-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine; 8-chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)methyl]-4-piperidinylidene]-5H-benzo[5,6]cyclohepta[1,2-b]pyridine; UR-12592; 8-Chloro-11-{1-[(5-methyl-3-pyridinyl)methyl]-4-piperidinylidene}-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine; 8-chloro-11-[1-[(5-methyl-3-pyridyl)methyl]piperidin-4-ylidene]-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine; MFCD00926499; 8-chloro-6,11-dihydro-11-(1-((5-methyl-3-pyridyl)methyl)-4-piperidylidene)-5h-benzo(5,6)cyclohepta(1,2-b)pyridine; 5H-Benzo(5,6)cyclohepta(1,2-b)pyridine, 8-chloro-6,11-dihydro-11-(1-((5-methyl-3-pyridinyl)methyl)-4-piperidinylidene)-; Rupatadinefumarate; 8-chloro-11-[1-[(5-methyl-3-pyridyl)methyl]-4-piperidyliden]-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine; Rupatadine; UNII-2AE8M83G3E; 8-Chloro-11-(1-((5-methylpyridin-3-yl)methyl)piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine; Rupatadine Fumarate

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 586.4±50.0 °C at 760 mmHg
• 熔点: 58-61ºC
• 分子式: C₂₆H₂₆ClN₃
• 分子量: 415.958
• 闪点: 308.4±30.1 °C
• 精确质量: 415.181519
• PSA: 29.02000
• LogP: 6.11
• 外观性状: 灰白色粉末
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.646
• 储存条件: 2-8℃

生物活性

• 描述: Rupatadine(UR-12592)是PAF/H1受体双效抑制剂,Ki值分别为0.55uM和0.1uM。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Merlos M, et al. Rupatadine, a new potent, orally active dual antagonist of histamine and platelet-activating factor (PAF). J Pharmacol Exp Ther. 1997 Jan;280(1):114-21.

  [2]. Queralt M, et al. In vitro inhibitory effect of rupatadine on histamine and TNF-alpha release from dispersed canine skin mast cells and the human mast cell line HMC-1. Inflamm Res. 2000 Jul;49(7):355-60.

  [3]. Lv XX, et al. Rupatadine protects against pulmonary fibrosis by attenuating PAF-mediated senescence in rodents. PLoS One. 2013 Jul 15;8(7):e68631.

安全

• 海关编码: 2933990090

合成路线

120276-47-3 100643-71-8 ~% 158876-82-5

文献：Journal of Medicinal Chemistry, , vol. 37, # 17 p. 2697 - 2703

591-22-0 100643-71-8 ~% 158876-82-5

文献：WO2006/103688 A1, ; Page/Page column 5-6 ;

591-22-0 ~% 158876-82-5

文献：Journal of Medicinal Chemistry, , vol. 37, # 17 p. 2697 - 2703

3222-49-9 ~% 158876-82-5

文献：Journal of Medicinal Chemistry, , vol. 37, # 17 p. 2697 - 2703

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海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%