125995-03-1

• 常用中文名：阿托伐他汀中间体 L-6
• 常用英文名：Atorvastatin lactone
• CAS号：125995-03-1
• 分子式：C₃₃H₃₃FN₂O₄
• 分子量：540.625
• 相关类别： 信号通路 代谢酶/蛋白酶 HMG-CoA还原酶(HMGCR)
• 发布时间：2018-03-23 08:00:00
• 更新时间：2026-06-30 16:28:38
• Atorvastatin lactone 是 Atorvastatin 的前药。Atorvastatin 是一种口服活性的 3- 羟基 -3- 甲基戊二酰辅酶 A (HMG-CoA) 还原酶抑制剂。

名称

• 中文名: 阿托伐他汀内酯
• 英文名: 5-(4-fluorophenyl)-1-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-N,4-diphenyl-2-propan-2-ylpyrrole-3-carboxamide
• 中文别名: 阿托伐他汀相关化合物H; 阿托伐他汀钙杂质H 标准品; 阿托伐他汀杂质H(阿托伐他汀有关化合物H); 5-(4-氟苯基)-2-(1-甲基-乙基)-N,4-二联苯-1-[2-[(2R,4R)-四氢-羟基-6-氧代-2H-吡喃-2-yl]乙基]-1H-吡咯-3-羧酸胺盐; 5-(4-氟苯基)-2-(1-甲基乙基)-N,4-二联苯-1-[2-[(2R,4R)-四氢-4-羟基-6-氧代-2H-吡喃-2-基]乙基]-1H-吡咯-3-甲酰胺; 阿伐他汀杂质H; 阿托伐他汀杂质H(阿托伐他汀内酯); (4R,6R)-6-{2-[2-(4-氟苯基)-5-异丙基-3-苯基-4-(苯基氨基甲酰基)吡咯-1-基]乙基}-4-羟基四氢-2H-吡喃-2-酮; 阿托伐他汀杂质H; 阿托伐他汀钙杂质H; 阿托伐他汀钙杂质H1; 阿托伐他汀中间体L-6; 阿托伐他汀钙杂质H(阿托伐他汀内酯); 阿托伐他汀内脂; 阿托伐他汀内酯杂质H); 阿托伐他汀杂质23(阿托伐他汀杂质H); 5-(4-氟苯基)-2-(1-甲基-乙基)-N,4-二联苯-1-[2-[(2R,4R)-四氢-羟基-6-氧代-2H-吡喃-2-YL]乙基]-1H-吡咯-3-酸胺; 阿托伐他汀相关杂质; 阿托伐他汀内酯,10 MM DMSO 溶液; 5-(4氟苯基)-2-(1-甲基乙基)_N.4=联苯-:(2R.4R)-四氢羟基-6-氧代2H吡喃-2-则乙基1_1H_吡咯3羧酸胺盐; 5-(4-氟苯基)-2-(1-甲基-乙基)-N,4-二联苯-1-[2-[(2R,4R)-四氢-羟基-6-氧代-2H-吡喃-2-YL]乙基]-1H-吡咯-3-羧酸胺盐; 阿托伐他汀D5硫丹内酯
• 英文别名: Atorvastatin calcium-6; 1H-Pyrrole-3-cboxamide, 5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]; (4R,6R)-6-[2-[2-(4-Fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-(phenylcbamoyl)-1H-pyrrol-1-yl]ethyl]-4-hydroxytetrahydro-2H-pyran-2-one (Atorvastatin Lactone); Atorvastatin RC H; ATORVASTATIN LACTONE; Atorvastatin Calcium Hydrate impurity H; Atorvastatin Calcium Trihydrate Impurity H; Dioxide Atorvastatin Lactone Dioxide; Atorvastatin calcium impurity H; Atorvastatin Impurity H RC H)Ator. Lacton; PD-130694; 5-(4-Fluorophenyl)-1-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-N,4-di(phenyl)-2-propan-2-ylpyrrole-3-carboxamide; (3R,5R)-7-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-yl]-3,5-dihydroxyhtanoic acid 1,5-lactone; Atorvastatin Impurity H (Atorvastatin Related Compound H, Atorvastatin Lactone); 5-(4-fluorophenyl)-1-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-N,4-diphenyl-2-(propan-2-yl)-1H-pyrrole-3-cboxamide; Atorvastatin Impurity 23; Atorvastatin Lactone (Atorvastatin Impurity H); 1-[2-[[(2R)-Tetrahydro-4β-hydroxy-6-oxo-2H-pyran]-2α-yl]ethyl]-5-(4-fluorophenyl)-2-isopropyl-4,N-diphenyl-1H-pyrrole-3-cboxamide; Atorvastatin impurity 9/Atorvastatin Impurity H/Atorvastatin Lactone/5-(4-fluorophenyl)-2-(1-methyl-ethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro- hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-cboxamide; Atorvastatin Impurity H; Atorvastatin Impurity H (Atorvastatin Lactone); Atorvastatin d-Lactone; Atorvastatin lactone, 10 mM in DMSO; 5-(4-Fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-cboxamide; Atorvastatin Calcium Impurity D; Benzeneacetamide,a-cyano-4-methoxy; Atorvastatin Related Compound H; 5-(4-fluorophenyl)-1-(2-((2R,4R); 5-(4-Fluorophenyl)-1-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide; 5-(4-Fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide; (4R,6R)-6-{2-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcbamoyl)pyrrol-1-yl]ethyl}-4-hydroxytetrahydro-2H-pyran-2-one; (4R,6R)-6-[2-[2-(4-Fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-(phenylcbamoyl)-1H-pyrrol-1-yl]ethyl; Atorvastatin D5 LactoneQ: What is Atorvastatin D5 Lactone Q: What is the CAS Number of Atorvastatin D5 Lactone Q: What is the storage condition of Atorvastatin D5 Lactone Q: What e the applications of Atorvastatin D5 Lactone; LACTONE IMPURITY(IMP-H); Atorvastatin lactone ( imp H); Atorvastatin IMp H RCH); AtorvastatinImpurityH-d5; Atorvastatin Related Compound H (20 mg) (5-(4-Fluorophenyl)-1-{2-[(2R, 4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-cboxamide); (4R,6R)-6-[2-[2-(4-Fluorophenyl)-5; Atorvastatin lactone impurity H); 5-(4-fluorophenyl)-1-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-N,4-diphenyl-2-propan-2-ylpyrrole-3-cboxamide; (RS) Atorvastatin Lactone; Atorvastatin Related Compound H (1044582)Q: What is Atorvastatin Related Compound H Q: What is the CAS Number of Atorvastatin Related Compound H; Atorvastatin Impurity H/ Atorvastatin Related Compound H (Atorvastatin Lactone); Atorvastatin LactoneQ: What is Atorvastatin Lactone Q: What is the CAS Number of Atorvastatin Lactone Q: What is the storage condition of Atorvastatin Lactone Q: What e the applications of Atorvastatin Lactone; (4R,6R)-6-[2-[2-(4-flfluorophenyl)-5-(1-methylethyl)-3- phenyl-4-(phenylcbamoyl)-1H-pyrrol-1-yl]ethyl]-4- hydroxytetrahydro-2H-pyran-2-one; 4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 674.8±55.0 °C at 760 mmHg
• 熔点: 103-106ºC
• 分子式: C₃₃H₃₃FN₂O₄
• 分子量: 540.625
• 闪点: 361.9±31.5 °C
• 精确质量: 540.242432
• PSA: 80.56000
• LogP: 4.30
• 外观性状: 略黄色固体
• 蒸汽压: 0.0±2.2 mmHg at 25°C
• 折射率: 1.617
• 储存条件: 室温，干燥

生物活性

• 描述: Atorvastatin lactone 是 Atorvastatin 的前药。Atorvastatin 是一种口服活性的 3- 羟基 -3- 甲基戊二酰辅酶 A (HMG-CoA) 还原酶抑制剂。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> HMG-CoA还原酶(HMGCR)
  研究领域 >> 炎症/免疫
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Valesky RJ, et al. Automated enzyme inhibition assay method for the determination of atorvastatin-derived HMG-CoA reductase inhibitors in human plasma using radioactivity detection. J Pharmacol Toxicol Methods. 2008 Jan-Feb;57(1):61-9.

安全

• 危险品运输编码: UN 2811 6.1 / PGII
• 海关编码: 2934999090

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海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%