290297-26-6

• 常用中文名：奈妥匹坦
• 常用英文名：Netupitant
• CAS号：290297-26-6
• 分子式：C₃₀H₃₂F₆N₄O
• 分子量：578.592
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 神经激肽受体
• 发布时间：2018-03-04 08:00:00
• 更新时间：2026-07-09 11:33:13
• Netupitant (CID-6451149) 是一高效、选择性、口服活性的Neurokinin-1受体(NK1)拮抗剂,Ki值为0.95nM。

名称

• 中文名: 奈妥吡坦
• 英文名: netupitant
• 中文别名: 奈妥吡坦/萘妥吡坦; 2-(3,5-双(三氟甲基)苯基)-N,2-二甲基-N-(6-(4-甲基哌嗪-1-基)-4-(邻甲苯基)吡啶-3-基)丙酰胺; 网联; 2-[3,5-双(三氟甲基)苯基]-N,2-二甲基-N-[4-(2-甲基苯基)-6-(4-甲基哌嗪-1-基)吡啶-3-基]丙酰胺; 萘妥匹坦相关杂质; 萘妥吡坦; 网状物杂质; 奈妥匹坦(包括很多杂质); 网友; 奈瑞匹坦; 奈妥吡坦 290-6; Netupitant ,奈妥吡坦; 抑制剂Netupitant
• 英文别名: Netupitant(CID-6451149); NetupitantQ: What is Netupitant Q: What is the CAS Number of Netupitant Q: What is the storage condition of Netupitant Q: What e the applications of Netupitant; 2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-meth; 2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide; CID6451149; Ro 98/000; 2-[3,5-Bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinyl]propanamide; 2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide; 2-(3,5-bis(trifluoroMethyl)phenyl)-N,2- diMethyl-N-(6-(4-Methylpiperazin-1-yl)-4- o-tolylpyridin-3-yl)propanaMide; 2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3; BenzeneacetaMide, N,a,a-triMethyl-N-[4-(2-Methylphenyl)-6-(4-Methyl-1-piperazinyl)-3-pyridinyl]-3,5-bis(trifluoroMethyl); Benzeneacetamide, N,α,α-trimethyl-N-[4-(2-methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinyl]-3,5-bis(trifluoromethyl); 5-bis(trifluoromethyl)phenyl]-N; UNII-7732P08TIR; 2-[3,5-Bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-y; CID-6451149; Ro 98; Netupitan; NETUPITANT (RO 98); Ro 67-3189/000; 2-[3,5-Bis(trifluoromethyl)phenyl]-N-[6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl]-N-methylisobutyramide

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 597.4±50.0 °C at 760 mmHg
• 分子式: C₃₀H₃₂F₆N₄O
• 分子量: 578.592
• 闪点: 315.1±30.1 °C
• 精确质量: 578.248047
• PSA: 39.68000
• LogP: 6.39
• 外观性状: 粉末
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.540
• 储存条件: -20℃

生物活性

• 描述: Netupitant (CID-6451149) 是一高效、选择性、口服活性的Neurokinin-1受体(NK1)拮抗剂,Ki值为0.95nM。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 神经激肽受体
  信号通路 >> 神经信号通路 >> 神经激肽受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Hoffmann T, et al. Design and synthesis of a novel, achiral class of highly potent and selective, orally active neurokinin-1 receptor antagonists. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1362-5.

  [2]. Stathis M, et al. Inhibition of substance P-mediated responses in NG108-15 cells by netupitant and palonosetron exhibit synergistic effects. Eur J Pharmacol. 2012 Aug 15;689(1-3):25-30.

  [3]. Rizzi A, et al. In vitro and in vivo pharmacological characterization of the novel NK1 receptor selective antagonist Netupitant. Peptides. 2012 Sep;37(1):86-97.

  [4]. Ajit G. Thomas, et al. Netupitant and palonosetron trigger NK1 receptor internalization in NG108-15 cells. Exp Brain Res. 2014; 232(8): 2637–2644.

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