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632-85-9生产厂家

632-85-9价格

632-85-9

632-85-9结构式
632-85-9结构式

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中文名 汉黄芩素
英文名 wogonin
中文别名 5,7-二羟基-8-甲氧基-2-苯基-4H-1-苯并呋喃-4-酮
5,7-二羟基-8-甲氧基-2-苯基-4H-1-苯并呋喃-4-酮
汉黄芩黄酮
英文别名 Norwogonin 8-methyl ether
5,7-DIHYDROXY-8-METHOXYFLAVON
5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-on
Wogonin
5,7-Dihydroxy-8-methoxy-2-phenyl-4H-chromen-4-one
5,7-dihydroxy-8-methoxy-2-phenyl-chromen-4-one
4H-1-Benzopyran-4-one, 5,7-dihydroxy-8-methoxy-2-phenyl-
MFCD00017736
5,7-dihydroxy-8-methoxyflavone
vogonin
WOOGONIN
WILDYAMP.E
描述 Wogonin 是一种天然黄酮类物质,能够抑制 CDK8 and Wnt 的活性,具有抗炎、抗肿瘤等功效。
相关类别
靶点

CDK8

Wnt

体外研究 汉黄芩素(0-200μM)表现出caco-2,SW1116和HCT116细胞的细胞活力的剂量和时间依赖性降低。汉黄芩素(10-40μM)诱导HCT-116细胞G1期阻滞。汉黄芩素还抑制HCT116细胞中的Wnt信号传导途径。 Wogonin干扰转录因子TCF/Lef家族的活动。此外,汉黄芩素通过抑制CDK8的活性来抑制β-连环蛋白介导的转录[1]。汉黄芩素对HeLa细胞具有细胞毒性和抗增殖作用。汉黄芩素(90μM)在G0-G1期诱导细胞周期停滞,并在HeLa细胞中显着抑制细胞周期蛋白D1和Cdk4的水平[2]。汉黄芩素(1.25,2.5,5,10,20μg/ ml)抑制RAW264.7细胞中EtOH诱导的炎症反应[3]。
体内研究 汉黄芩素(30,60 mg/kg)可降低异种移植模型中HCT116细胞的肿瘤生长[1]。汉黄芩素(25,50,100 mg/kg)可预防小鼠肝脏损伤和ALD的病理特征。汉黄芩素激活ALD和EtOH诱导的RAW264.7细胞小鼠的PPAR-γ表达[3]。
细胞实验 将HCT116细胞种植在96孔板上(每孔1×10 5个细胞)。加入不同浓度的汉黄芩素并孵育24小时。随后,将20μLMTT溶液(5mg / mL)转移至每个孔中,并将板在37℃和5%CO 2下孵育4小时。吸去上清液并加入100μLDMSO以溶解甲crystals晶体。摇动混合物并使用通用酶标仪在570nm下测量。
动物实验 将C57BL / 6小鼠,雄性,6-8周龄,体重18-22g小鼠饲养在舒适的环境中并在实验前适应3天。将总共48只小鼠随机分成6组,每组8只动物,分别为对照饮食(CD)喂养的小鼠,喂食EtOH的小鼠,以25,50,100mg / kg /天的剂量处理的汉黄芩素小鼠和阳性(地塞米松,1mg / kg /天)治疗的小鼠。建模过程总共有16天,包括3天的液体饮食适应期和13天的模型。喂食EtOH喂养的小鼠含有5%v / v乙醇液体饮食,添加某些维生素和胆碱16天,并且最后用单次狂欢乙醇(5g / kg,体重,20%乙醇)强饲小鼠。天。同时,汉黄芩素治疗的小鼠和阳性治疗的小鼠不仅加上乙醇给药,而且还加上每天灌胃的药物,而CD喂养的小鼠用对照液体饲料喂养并用等热量麦芽糖强饲。 -dextrin在最后一天。所有饮食均每天新鲜烹制。在最后一次灌胃酒精后9小时,在麻醉下处死小鼠,收集肝脏组织和血液用于进一步分析。
参考文献

[1]. He L, et al. Wogonin induced G1 cell cycle arrest by regulating Wnt/β-catenin signaling pathway and inactivating CDK8 in human colorectal cancer carcinoma cells. Toxicology. 2013 Oct 4;312:36-47.

[2]. Yang L, et al. Wogonin induces G1 phase arrest through inhibiting Cdk4 and cyclin D1 concomitant with an elevation in p21Cip1 in human cervical carcinoma HeLa cells. Biochem Cell Biol. 2009 Dec;87(6):933-42.

[3]. Li HD, et al. Wogonin attenuates inflammation by activating PPAR-γ in alcoholic liver disease. Int Immunopharmacol. 2017 Sep;50:95-106.

密度 1.4±0.1 g/cm3
沸点 518.8±50.0 °C at 760 mmHg
熔点 203-206°C
分子式 C16H12O5
分子量 284.263
闪点 198.4±23.6 °C
精确质量 284.068481
PSA 79.90000
LogP 2.14
外观性状 黄色晶体
蒸汽压 0.0±1.4 mmHg at 25°C
折射率 1.669
储存条件

存放在密封容器内,并放在阴凉,干燥处,2-10ºC避光保存。储存的地方必须远离氧化剂。

稳定性

远离氧化物,光,热。

分子结构

1、 摩尔折射率:74.64

2、 摩尔体积(m3/mol):200.1

3、 等张比容(90.2K):564.8

4、 表面张力(dyne/cm):63.4

5、 极化率(10-24cm3):29.59

计算化学

1.疏水参数计算参考值(XlogP):3

2.氢键供体数量:2

3.氢键受体数量:5

4.可旋转化学键数量:2

5.互变异构体数量:12

6.拓扑分子极性表面积76

7.重原子数量:21

8.表面电荷:0

9.复杂度:426

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

更多

1. 性状:黄色结晶或者结晶性粉末。

2. 密度(g/mL,25/4℃):未确定

3. 相对蒸汽密度(g/mL,空气=1):未确定

4. 熔点(ºC):203-206

5. 沸点(ºC,常压):未确定

6. 沸点(ºC,5.2kPa):未确定

7. 折射率:未确定

8. 闪点(ºC):未确定

9. 比旋光度(º):未确定

10. 自燃点或引燃温度(ºC):未确定

11. 蒸气压(kPa,25ºC):未确定

12. 饱和蒸气压(kPa,60ºC):未确定

13. 燃烧热(KJ/mol):未确定

14. 临界温度(ºC):未确定

15. 临界压力(KPa):未确定

16. 油水(辛醇/水)分配系数的对数值:未确定

17. 爆炸上限(%,V/V):未确定

18. 爆炸下限(%,V/V):未确定

19. 溶解性:几乎不溶于水,微溶于醇类。


SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifiers
Product name: Wogonin hydrate
REACH No.: A registration number is not available for this substance as the substance
or its uses are exempted from registration, the annual tonnage does not
require a registration or the registration is envisaged for a later
registration deadline.
CAS-No.: 632-85-9
Relevant identified uses of the substance or mixture and uses advised against
Identified uses: Laboratory chemicals, Manufacture of substances



SECTION 2: Hazards identification
Classification of the substance or mixture
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.
Label elements
The product does not need to be labelled in accordance with EC directives or respective national laws.
Other hazards - none

SECTION 3: Composition/information on ingredients
Substances
Synonyms: 5,7-Dihydroxy-8-methoxyflavone
Formula: C16H12O5 · xH2O
Molecular Weight: 284,26 g/mol
CAS-No.: 632-85-9
No components need to be disclosed according to the applicable regulations.

SECTION 4: First aid measures
Description of first aid measures
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration.
In case of skin contact
Wash off with soap and plenty of water.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water.
Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
section 11
Indication of any immediate medical attention and special treatment needed
no data available

SECTION 5: Firefighting measures
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
no data available

SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Avoid dust formation. Avoid breathing vapours, mist or gas.
For personal protection see section 8.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Sweep up and shovel. Keep in suitable, closed containers for disposal.
Reference to other sections
For disposal see section 13.

SECTION 7: Handling and storage
Precautions for safe handling
Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire
protection.
For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Recommended storage temperature: 2 - 8 °C
Specific end use(s)
A part from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
General industrial hygiene practice.
Personal protective equipment
Eye/face protection
Use equipment for eye protection tested and approved under appropriate government standards
such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Body Protection
Choose body protection in relation to its type, to the concentration and amount of dangerous
substances, and to the specific work-place., The type of protective equipment must be selected
according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
Respiratory protection is not required. Where protection from nuisance levels of dusts are desired,
use type N95 (US) or type P1 (EN 143) dust masks. Use respirators and components tested and
approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Do not let product enter drains.

SECTION 9: Physical and chemical properties
Information on basic physical and chemical properties
a) AppearanceForm: solid
b) Odourno data available
c) Odour Thresholdno data available
d) pHno data available
e) Melting point/freezingno data available
point
f) Initial boiling point and no data available
boiling range
g) Flash pointno data available
h) Evapouration rateno data available
i) Flammability (solid, gas) no data available
j) Upper/lowerno data available
flammability or
explosive limits
k) Vapour pressureno data available
l) Vapour densityno data available
m) Relative densityno data available
n) Water solubilityno data available
o) Partition coefficient: n- no data available
octanol/water
p) Auto-ignitionno data available
temperature
q) Decompositionno data available
temperature
r) Viscosityno data available
s) Explosive propertiesno data available
t) Oxidizing propertiesno data available
Other safety information
no data available

SECTION 10: Stability and reactivity
Reactivity
no data available
Chemical stability
Stable under recommended storage conditions.
Possibility of hazardous reactions
no data available
Conditions to avoid
no data available
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
Other decomposition products - no data available
In the event of fire: see section 5

SECTION 11: Toxicological information
Information on toxicological effects
Acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitisation
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
IARC:No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
no data available
Specific target organ toxicity - single exposure
no data available
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Additional Information
RTECS: LK8331000
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.

SECTION 12: Ecological information
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
Other adverse effects
no data available

SECTION 13: Disposal considerations
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contaminated packaging
Dispose of as unused product.

SECTION 14: Transport information
UN number
ADR/RID: -IMDG: -IATA: -
UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA:Not dangerous goods
Transport hazard class(es)
ADR/RID: -IMDG: -IATA: -
Packaging group
ADR/RID: -IMDG: -IATA: -
Environmental hazards
ADR/RID: noIMDG Marine pollutant: noIATA: no
Special precautions for user
no data available

SECTION 15: Regulatory information
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
Safety, health and environmental regulations/legislation specific for the substance or mixture
no data available
Chemical Safety Assessment
For this product a chemical safety assessment was not carried out

SECTION 16: Other information
Further information
Copyright 2013 Co. LLC. License granted to make unlimited paper copies for internal use
only.
The above information is believed to be correct but does not purport to be all inclusive and shall be
used only as a guide. The information in this document is based on the present state of our knowledge
and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Corporation and its Affiliates shall not be held
liable for any damage resulting from handling or from contact with the above product. See
and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

生态学数据:

通常对水是不危害的,若无政府许可,勿将材料排入周围环境。

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LK8331000
CHEMICAL NAME :
Flavone, 5,7-dihydroxy-8-methoxy-
CAS REGISTRY NUMBER :
632-85-9
BEILSTEIN REFERENCE NO. :
0287152
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C16-H12-O5
MOLECULAR WEIGHT :
284.28
WISWESSER LINE NOTATION :
T66 BO EVJ CR& GQ IQ JO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
20 nmol/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 135,77,1984

危害码 (欧洲) Xn
风险声明 (欧洲) R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . R36/37/38:Irritating to eyes, respiratory system and skin .
安全声明 (欧洲) S26-S36/37/39-S45
危险品运输编码 3145
RTECS号 SJ8922500
包装等级 III
危险类别 8