567-02-2

• 常用中文名：3alpha,21-二羟基-5alpha-孕甾-20-酮
• 常用英文名：THDOC
• CAS号：567-02-2
• 分子式：C₂₁H₃₄O₃
• 分子量：334.49300
• 相关类别： 信号通路 跨膜转运 GABA受体
• 发布时间：2018-12-27 17:16:48
• 更新时间：2026-07-09 18:16:49
• 3α,21-二羟基-5α-pregnan-20-one(THDOC)是一种内源性神经甾体,是GABAA受体的正调节因子。3α,21-二羟基-5α-pregnan-20-one可增强神经元对低浓度GABA在α4β1δGABAA受体的反应。

名称

• 中文名: 3alpha,21-二羟基-5alpha-孕甾-20-酮
• 英文名: 2-hydroxy-1-[(8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
• 中文别名: 化合物 3Α,21-DIHYDROXY-5Α-PREGNAN-20-ONE; 四氢脱氧皮质酮; 异四氢脱氧皮质酮; 异四氢脱氧皮质酮(溶液); 3ALPHA,21-二羟基-5ALPHA-孕甾-20-酮; 3Α,21-二羟基-5Α-孕烷-20-酮; 5-ALPHA-孕甾-3ALPHA,21-二羟基-20-酮非标; 5Β孕3Α,21-二醇-20-酮-17Α,21,21-D3; 21-羟基全孕烯醇酮; 5α-孕甾烷-3α,21-二醇-20-酮; 5-ALPHA-孕甾-3ALPHA,21-二羟基-20-酮(17,21,21-D3,)
• 英文别名: 5-ALPHA-PREGNAN-3-ALPHA, 21-DIOL-20-ONE; 3α,21-dihydroxy-5α-pregnan-20-one; [3H]-Allotetrahydrodeoxycorticosterone; 5alpha-Pregnan-3alpha,21-diol-20-one-17,21,21-D3; 3α,21Dihydroxy5αpregnan20one,3α,21 Dihydroxy 5α pregnan 20 one; ALLOPREGNANE-3ALPHA,21-DIOL-20-ONE; Allotetrahydrodeoxycorticosterone (Solution); 21-HYDROXYALLOPREGNANOLONE; ALLOTETRAHYDRO DOC; ALLO TH DOC; Allopregnane-3α,21-diol-20-one; 5ALPHA-PREGNANE-3ALPHA,21-DIOL-20-ONE; 5α-Pregnan-3α,21-diol-20-one-17,21,21-D3; Pregnan-20-one, 3,21-dihydroxy-, (3α,5α); 5A-pregnane-3A,21-diol-20-one; TDOC; 21-Hydroxyallopregnanolone, 5α-Pregnane-3α,21-diol-20-one, 5α-THDOC, Allopregnane-3α,21-diol-20-one, Allotetrahydrodeoxycorticosterone; "3α,21-Dihydroxy-5a-pregnan-20-one"; 1-HYDROXYALLOPREGNANOLONE; 5α-Pregnane-3α,21-diol-20-one; 3ALPHA,21-DIHYDROXY-5ALPHA-PREGNAN-20-ONE; ALLOTETRAHYDRODESOXYCORTICOSTERONE; ALLOTETRAHYDRODEOXYCORTICOSTERONE; 3α,5α-THDOC; 3β,5α-Tetrahydrodeoxycorticosterone; 5α-THDOC; 5α-PREGNAN-3α, 21-DIOL-20-ONE; ALLOTETRADEOXYCORTICOSTERONE; ALLOTETRAHYDROCORTEXONE; 5alpha-THDOC; ALLOTETRAHYDRO SUBSTANCE 'Q'

物化性质

• 密度: 1.115g/cm3
• 沸点: 470.3ºC at 760mmHg
• 分子式: C₂₁H₃₄O₃
• 分子量: 334.49300
• 闪点: 252.3ºC
• 精确质量: 334.25100
• PSA: 57.53000
• LogP: 3.56760
• 折射率: 1.54

生物活性

• 描述: 3α,21-二羟基-5α-pregnan-20-one(THDOC)是一种内源性神经甾体,是GABAA受体的正调节因子。3α,21-二羟基-5α-pregnan-20-one可增强神经元对低浓度GABA在α4β1δGABAA受体的反应。
• 相关类别:
  信号通路 >> 跨膜转运 >> GABA受体
  信号通路 >> 神经信号通路 >> GABA受体

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危险品运输编码: NONH for all modes of transport

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