82752-99-6

• 常用中文名：奈法唑酮盐酸盐
• 常用英文名：Nefazodone hydrochloride
• CAS号：82752-99-6
• 分子式：C₂₅H₃₃Cl₂N₅O₂
• 分子量：506.46800
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 5-HT受体
• 发布时间：2018-07-19 13:55:45
• 更新时间：2026-07-03 16:40:53
• Nefazodone 盐酸盐是一种抗抑郁药物。

名称

• 中文名: 萘法唑酮盐酸盐
• 英文名: nefazodone hydrochloride
• 中文别名: 1-(3-(4-(3-氯苯基)哌嗪-1-基)丙基)-3-乙基-4-(2-苯氧基乙基)-1H-1,2,4-三唑-5(4H)-酮盐酸盐; 盐酸萘法唑酮; 萘法唑酮盐酸盐 标准品; DUTONIN|||MJ-13754-1|||SERZONE|||BMY-13|||BMY-13754|||萘法唑酮盐酸盐; 萘法唑酮盐酸盐,10 MM DMSO 溶液; 萘法唑酮盐酸盐( Nefazodone Hydrochloride ) 其他西药原料; 盐酸奈法唑酮 标准品; NEFAZODONE HYDROCHLORIDE,5-HT2A拮抗剂; 乙腈中奈法唑酮盐酸盐(以奈法唑酮计); 氘代盐酸奈法唑酮-d5; 盐酸奈法唑酮
• 英文别名: Z-DL-proline ≥ Ethyl 4-hydroxy-6-methylquinoline-3-cboxylate ≥ 1-(3-(4-(3-Chlorophenyl)piperazin-1-yl)propyl)-3-ethyl-4-(2-phenoxyethyl)-1H-1,2,4-triazol-5(4; NEFAZODONE; Boc-L-propraglycine dicyclohexylammonium salt ≥ BMY-13754, MJ-13754-1, Serzone, 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl- 2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride; BMY 13; MFCD00865396; 1-(3-(4-(3-Chlorophenyl)piperazin-1-yl)propyl)-3-ethyl-4-(2-phenoxyethyl)-1H-1,2,4-triazol-5(4H); 4-(4-Nitrophenoxy)Benzoic Acid ≥ Nefazodone hydrochlo; Z-6-aminohexanoic acid ≥ Fmoc-4-amino-L-phenylalanine ≥ Na-Z-D-tryptophan ≥ 11-Tritylmercapto-undecanoic acid ≥ 3H-1,2,4-Triazol-3-one, -4-(3-chlorophenyl)-1-piperazinylpropyl-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-, monohydrochloride; Boc-D-cyclopropylglycine ≥ Serazone; 4-Amino-2-chloro-5-nitropyridine ≥ Pentafluoro-L-b-homophenylalanine hydrochloride ≥ 4-Chloro-6,7-dimethoxyquinazoline ≥ 1-(3-(4-(3-Chlorophenyl)piperazin-1-yl)propyl)-3-ethyl-4-(2-phenoxyethyl)-1H-1,2,4-triazol-5(4H)-one hydrochloride; Fmoc-L-asptic acid a-allyl ester ≥ 2-(4-Methoxyphenyl)succinic acid ≥ Methyl 2-Hydroxy-4-Morpholinobenzoate ≥ 6-Bromo-DL-tryptophan ≥ 1-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-3-ethyl-4-(2-phenoxyethyl)-4,5-dihydro-1H-1,2,4-triazol-5-one; Na-Fmoc-Ng-Boc-D-2,4-diaminobutyric acid ≥ >= (HPLC); Nefazodone Hydrochloride; 4-(4-Nitrophenoxy)benzaldehyde ≥ Z-L-threonine methyl ester ≥ Nefazodone hydrochloride API; 5-Amino-3-(4-bromophenyl)pyrazole ≥ Nefazodone HCl; (R,S)-Fmoc-2-amino-4,4,4-trifluoro-butyric acid ≥ Formyl-L-methionine ≥ 5-(4-Fluorophenyl)-1,3,4-oxadiazole-2-thiol ≥ O-Benzyl-L-serine methyl ester hydrochloride ≥ 3-(4-Methylphenyl)-1H-pyrazole-5-cboxylic acid ≥ Boc-4,4-Difluoro-L-proline ≥ Z-L-alanine-N-hydroxysuccinimide ester ≥ NEFAZODONE-D5 HCL; 4-(Bromomethyl)-3-(4-chlorophenyl)-5-methylisoxazole ≥ Z-L-pyroglutamic acid N-hydroxysuccinimide ester ≥ Fmoc-Ne-methyltrityl-D-lysine ≥ Boc-a-methyl-L-phenylalanine ≥ diphosphate potassium salt ≥ 2-Amino-6-methyl-5-nitropyridine ≥ 2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-5-ethyl-4-(2-phenoxyethyl)-1,2,4-triazol-3-one,hydrochloride; Indole-6-cboxaldehyde ≥ Boc-2-chloro-D-phenylalanine ≥ Ethyl 2-amino-4-methylpyrimidine-5-cboxylate ≥ 5-(4-Nitrophenyl)-1H-tetrazole ≥ 2,4-Dihydro-2-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-5-ethyl-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride; 3-(4-Methylphenyl)-1H-pyrazole-4-cbaldehyde ≥ 5-Azacytosine ≥ 3-(4-Bromophenyl)-1H-pyrazole-5-cboxylic acid ≥ 3-(4-Methoxyphenyl)-pyrazole-4-cboxylic acid &ge

物化性质

• 沸点: 599.6ºC at 760 mmHg
• 熔点: 186-188ºC
• 分子式: C₂₅H₃₃Cl₂N₅O₂
• 分子量: 506.46800
• 闪点: 316.4ºC
• 精确质量: 505.20100
• PSA: 55.53000
• LogP: 4.35680
• 外观性状: 白色固体
• 储存条件: Desiccate at RT
• 水溶解性: DMSO: ~11 mg/mL at 60 °C

生物活性

• 描述: Nefazodone 盐酸盐是一种抗抑郁药物。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Bengi Uslu, et al. Electrochemical characterisation of nefazodone hydrochloride and voltammetric determination of the drug in pharmaceuticals and human serum. Analytica Chimica Acta Volume 462, Issue 1, 26 June 2002, Pages 49–57

  [2]. SHEN Wei-Yang, et al. Determination of Nefazodone Hydrochloride Tablets by HPLC. Chinese Journal of Pharmaceuticals, 2003-10

MSDS

Material Safety Data Sheet Section1. Identification of the substance Product Name: Nefazodone HCl Synonyms: Section2. Hazards identification Harmful by inhalation, in contact with skin, and if swallowed. Section3. Composition/information on ingredients. Ingredient name:Nefazodone HCl CAS number:82752-99-6 Section4. First aid measures Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing contaminated clothing and shoes. If irritation persists, seek medical attention. Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical attention. Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention. Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention. Section5. Fire fighting measures In the event of a fire involving this material, alone or in combination with other materials, use dry powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus should be worn. Section6. Accidental release measures Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national standards. Respiratory precaution:Wear approved mask/respirator Hand precaution:Wear suitable gloves/gauntlets Skin protection:Wear suitable protective clothing Eye protection:Wear suitable eye protection Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container for disposal. See section 12. Environmental precautions: Do not allow material to enter drains or water courses. Section7. Handling and storage Handling:This product should be handled only by, or under the close supervision of, those properly qualified in the handling and use of potentially hazardous chemicals, who should take into account the fire, health and chemical hazard data given on this sheet. Store in closed vessels. Storage: Section8. Exposure Controls / Personal protection Engineering Controls: Use only in a chemical fume hood. Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles. General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse. Section9. Physical and chemical properties Appearance:Not specified Boiling point:No data No data Melting point: Flash point:No data Density:No data Molecular formula:C25H32ClN5O2.ClH Molecular weight:506.5 Section10. Stability and reactivity Conditions to avoid: Heat, flames and sparks. Materials to avoid: Oxidizing agents. Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride. Section11. Toxicological information No data. Section12. Ecological information No data. Section13. Disposal consideration Arrange disposal as special waste, by licensed disposal company, in consultation with local waste disposal authority, in accordance with national and regional regulations. Section14. Transportation information Non-harzardous for air and ground transportation. Section15. Regulatory information No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302, or have known CAS numbers that exceed the threshold reporting levels established by SARA Title III, Section 313. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 安全声明 (欧洲): 22-24/25
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3

合成路线

95885-13-5 52605-52-4 ~63% 82752-99-6

文献：Mead Johnson and Company Patent: US4487773 A1, 1984 ; US 4487773 A

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