2188-68-3

• 常用中文名：盐酸石蒜碱
• 常用英文名：Lycorine chloride
• CAS号：2188-68-3
• 分子式：C₁₆H₁₈ClNO₄
• 分子量：323.77
• 相关类别： 原料药 抗寄生虫病药 抗阿米巴病及抗滴虫病药
• 发布时间：2018-08-24 18:35:47
• 更新时间：2024-01-02 17:37:27
• Lycorine (hydrochloride) 是一种 VE-cadherin 抑制剂,在 Hey1B细胞中的 IC50为1.2μM。

名称

• 中文名: 盐酸石蒜碱
• 英文名: Lycorine hydrochloride
• 中文别名: 石蕊碱; 石蒜碱
• 英文别名: Lycorine hydrochloride; Lycorinehydrochloride; Licorin hydrochloride; galanthidine,hydrochloride; (1S,2S,12bS,12cS)-2,4,5,7,12b,12c-Hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol hydrochloride (1:1); 1H-[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol, 2,4,5,7,12b,12c-hexahydro-, (1S,2S,12bS,12cS)-, hydrochloride (1:1); Lycorinechloride; Lycorine (hydrochloride)

物化性质

• 沸点: 477.4ºC at 760 mmHg
• 熔点: 210-212ºC
• 分子式: C₁₆H₁₈ClNO₄
• 分子量: 323.77
• 闪点: 242.5ºC
• PSA: 62.16000
• LogP: 0.68650
• 外观性状: 细晶体粉末
• 蒸汽压: 6.37E-10mmHg at 25°C
• 储存条件: 2-8°C

生物活性

• 描述: Lycorine (hydrochloride) 是一种 VE-cadherin 抑制剂,在 Hey1B细胞中的 IC50为1.2μM。
• 相关类别:
  信号通路 >> 自噬 >> 自噬
  天然产物 >> 生物碱
  研究领域 >> 癌症
• 参考文献:

  [1]. Liu, R. et al. Lycorine hydrochloride inhibits metastatic melanoma cell-dominant vasculogenic mimicry. Pigment cell & melanoma research 25, 630-638, doi:10.1111/j.1755-148X.2012.01036.x (2012).

  [2]. Cao, Z. et al.Lycorine hydrochloride selectively inhibits human ovarian cancer cell proliferation and tumor neovascularization with very low toxicity. Toxicology letters 218, 174-185, doi:10.1016/j.toxlet.2013.01.018 (2013).

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : OL2910000 CHEMICAL NAME : Lycoran-1-alpha,2-beta-diol, 3,3-alpha-didehydro-, hydrochloride CAS REGISTRY NUMBER : 2188-68-3 LAST UPDATED : 198803 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C16-H17-N-O4.Cl-H MOLECULAR WEIGHT : 323.80 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 230 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 54,21,1958 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 117 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 54,21,1958 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 123 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - nausea or vomiting REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 54,21,1958

安全

• 符号: GHS06
• 信号词: Danger
• 危害声明: H301
• 警示性声明: P301 + P310
• 个人防护装备: Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
• 危害码 (欧洲): T: Toxic;
• 风险声明 (欧洲): R25
• 安全声明 (欧洲): 45
• 危险品运输编码: UN 2811
• 危险类别: 6.1