480-36-4

• 常用中文名：蒙花苷
• 常用英文名：Linarin
• CAS号：480-36-4
• 分子式：C₂₈H₃₂O₁₄
• 分子量：592.545
• 相关类别： 天然产物 黄酮类化合物
• 发布时间：2018-09-23 20:02:58
• 更新时间：2026-07-03 10:05:10
• Linarin (Buddleoside) 是从薄荷花提取物中分离得到的,选择性的抑制乙酰胆碱酯酶 (AChE)。
• 1.蒙花苷（金合欢素-7-O-β-d-芸香糖苷）对乙酰胆碱酯酶具有选择性剂量依赖性抑制作用。
  2. 蒙花苷通过抑制TNF-α介导的凋亡途径减轻GalN / LPS诱导的肝损伤。
  3. 蒙花苷通过激活PI3K / Akt来预防Aβ诱导的神经毒性，PI3K / Akt随后抑制GSK-3b并上调Bcl-2。
  4.胡椒碱通过在肠道吸收过程中抑制P-糖蛋白介导的细胞外流，并且可能同时抑制蒙花苷的代谢，显着增强大鼠中蒙花苷的口服吸收。

名称

• 中文名: 蒙花苷
• 英文名: 5-hydroxy-2-(4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one
• 中文别名: 蒙花苷, 来源于野菊花; 蒙花苷 -4 HPLC; 地奥司明杂质E; 5-羟基-2-(4-甲氧基苯基)-7-(((2S,3R,4S,5S,6R)-3,4,5-三羟基-6- ((((2R,3R,4R,5R,6S)-3,4,5-三羟基-6-甲基四氢-2H-吡喃-2-基)氧基)甲基)四氢-2H-吡喃-2-基)氧基)-4H-苯并吡喃-4-酮; 玄参苷; 蒙花苷(标准品); 蒙花苷(里哪苷,玄参苷); 蒙花苷/黄酮苷; 野菊花提取物; 罗恩 蒙花苷 R026139; 地奥司明杂质E/BP); 蒙花苷(分析标准品); 蝴蝶草苷; 地奥司明杂质6; 薯OS素杂质E; 里哪苷、玄参苷、刺槐苷; 地奥司明杂质E(利那林); 蒙花苷,金合欢素-7-O-(6''-O-鼠李糖)-Β-D-葡萄糖; 地奥司明杂质E (LININ); 蒙花甙; 玄參苷; 里哪苷,玄参苷; BUDDLEOSIDE 蒙花苷; 蒙花苷,10 MM DMSO 溶液; 【BUDDLEOSIDE 蒙花苷 标准品; 蒙花苷(对照品); 里哪苷; Linin #天然产物 HY-N0528; 蒙花苷LININ; 蒙花苷/HPLC
• 英文别名: Acaciin; 7-[[6-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-4'-methoxyflavone; Diosmin Impurity E(Linin); LININ; Acacetin 7-rutinoside; acacetin-7-O-ramnosyl-glucoside; ACACETIN-7-RUTINOSIDE; Linine (1.0 mg/mL in Methanol); 7-[[6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-5-hydroxy-4'-methoxyflavone; Diosmin Impurity 5 (Diosmin Impurity E)(Linin); Acacetin-b-rutinoside; Linarigenin-glucoside; Buddleoside -4; Buddloside，Linin; Linic acid; Linin from Dendranthema indicum (L.) Des Moul; apigenin-4'-methylether-7-O-rutinoside; 4H-1-Benzopyran-4-one, 7-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-2-(4-methoxyphenyl); 2-(4-methoxyphenyl)-4H-benzopyran-4-one; ACACETIN-7-O-RUTINOSIDE; Diosmin imp E; linarin; 7-[[6-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one; Extract of Chrysanthemum indicum; BUDDLEOSIDE; ACACETIN-7-RUTINOSIDE hplc; Acacetin-7-rutinoside; Buddleoflavonoloside; Diosmin Impurity EQ: What is Diosmin Impurity E Q: What is the CAS Number of Diosmin Impurity E Q: What is the storage condition of Diosmin Impurity E Q: What e the applications of Diosmin Impurity E; MFCD00151178; Linin -4; Linigenin glycoside; 5-Hydroxy-2-(4-methoxyphenyl)-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}methyl)tetrahydro-2H-pyran-2-yl]oxy}-4H-chromen-4-one; EINECS 207-547-6; 7-[[6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-5-hydroxy-2-(4-methoxyphenyl)-4H-benzopyran-4-one; Flos Chrysanthemi Indici Extract; Acaciin、Buddleoside; 5-Hydroxy-2-(4-methoxyphenyl)-4-oxo-4H-chromen-7-yl 6-O-(6-deoxy-a-L-mannopyranosyl)-b-D-glucopyranoside; 5-Hydroxy-2-(4-methoxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one; Acacetin-7-O-β-D-rutinoside; Linin, 10 mM in DMSO; 5,7-Dihydroxy-4'-methoxyflavone-D-glucosido-L-rhamnoside; Diosmin Impurity E (Linin); 5-Hydroxy-2-(4-methoxyphenyl)-4-oxo-4H-chromen-7-yl 6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside; 7-((6-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-5-hydroxy-2-(4-methoxyphenyl)-4H-benzopyran-4-one; 7-[[6-O-(6-Deoxy-a-L-mannopyranosyl)-b-D-glucopyranosyl]oxy]-5-hydroxy-2-(4-methoxyphenyl)-4H-benzopyran-4-one; Acacetin-7-O-rutinoside; Dioxamine Impurity E; Buddleoside; Linin (6CI, 7CI, 8CI); 7-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one (linin); Linine; Linin-RM; Linin Powder; Diosmin Impurity E; Buddleoglucoside; Buddleoside，Linin; 5-Hydroxy-2-(4-methoxyphenyl)-4-oxo-4H-chromen-7-yl-6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside; Acacetin 7-O-rutinoside; Acacetin 7-O-α-L-rhamnopyranosyl-(16)-β-D-glucopyranoside; 7-[[6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranos; Linin (50 mg); Linaric acid; 7-((6-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-5-hydroxy; BUDDLOSIDE

物化性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 885.2±65.0 °C at 760 mmHg
• 熔点: 258-260ºC
• 分子式: C₂₈H₃₂O₁₄
• 分子量: 592.545
• 闪点: 292.2±27.8 °C
• 精确质量: 592.179199
• PSA: 217.97000
• LogP: 2.10
• 外观性状: 白色至灰白色粉末
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.694
• 储存条件: 2~8°C

生物活性

• 描述: Linarin (Buddleoside) 是从薄荷花提取物中分离得到的,选择性的抑制乙酰胆碱酯酶 (AChE)。
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> 神经信号通路 >> 疼痛
• 参考文献:

  [1]. Päivi P. Oinonen,etc. Linarin, a selective acetylcholinesterase inhibitor from Mentha arvensis, Fitoterapia,Volume 77, Issue 6, 2006, Pages 429-434, ISSN 0367-326X

安全

• 危害码 (欧洲): Xi

合成路线

771480-96-7 ~54% 480-36-4

文献：Quintin, Jerome; Lewin, Guy Journal of Natural Products, 2004 , vol. 67, # 9 p. 1624 - 1627

520-27-4 ~% 480-36-4

文献：Quintin, Jerome; Lewin, Guy Journal of Natural Products, 2004 , vol. 67, # 9 p. 1624 - 1627

480-44-4 4154-21-6 ~% 480-36-4

文献：Zemplen; Bognar Chemische Berichte, 1941 , vol. 74, p. 1818,1821

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