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943-17-9生产厂家

943-17-9价格

943-17-9

943-17-9结构式
943-17-9结构式
  • 常用中文名:盐酸依替福林
  • 常用英文名:Efortil
  • CAS号:943-17-9
  • 分子式:C10H16ClNO2
  • 分子量:217.69
  • 相关类别: 分析化学 标准品 药典标准品和杂志标准品
  • 发布时间:2018-08-16 18:31:42
  • 更新时间:2024-01-09 18:25:14
  • 盐酸阿替勒林是一种口服活性α肾上腺素能激动剂。盐酸依替勒林也是AMPK激活剂。盐酸依替勒林可用于体位性低血压的研究[1][2][3][4]。

化源商城直购

中文名 盐酸依替福林
英文名 3-[2-(ethylamino)-1-hydroxyethyl]phenol,hydrochloride
中文别名 4-羟基-alpha-((乙基氨基)甲基)-苄醇盐酸盐
英文别名 etilefrine hydrochloride
Effortil
α-[(Ethylamino)methyl]-3-hydroxybenzenemethanol hydrochloride
N-Ethyl-1-(m-hydroxyphenyl)-2-aminoethanol hydrochloride
3-[2-(ethylamino)-1-hydroxyethyl]phenol hydrochloride
Thomasin
Benzenemethanol, α-[(ethylamino)methyl]-3-hydroxy-, hydrochloride (1:1)
Effortil*HCl
EINECS 213-398-8
Etilefrin-HCl
3-[2-(Ethylamino)-1-hydroxyethyl]phenol hydrochloride (1:1)
Etilefrin dl-form hydrochloride
Cardanat
Etilefrine HCl
Effontil
Efortil
Circupon
密度 1.127g/cm3
沸点 351.7ºC at 760 mmHg
熔点 122ºC
分子式 C10H16ClNO2
分子量 217.69
闪点 155.5ºC
精确质量 217.086960
PSA 52.49000
LogP 2.22800
储存条件 室温
水溶解性 Freely soluble in water, soluble in ethanol (96 per cent), practically insoluble in methylene chloride
分子结构

1、 摩尔折射率:52.08

2、 摩尔体积(m3/mol):160.7

3、 等张比容(90.2K):421.8

4、 表面张力(dyne/cm):47.3

5、 极化率(10 -24cm 3):20.64

计算化学

1.疏水参数计算参考值(XlogP):无

2.氢键供体数量:4

3.氢键受体数量:3

4.可旋转化学键数量:4

5.互变异构体数量:3

6.拓扑分子极性表面积52.5

7.重原子数量:14

8.表面电荷:0

9.复杂度:141

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:1

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:2

更多

1. 性状:未确定

2. 密度(g/mL,25/4℃):未确定

3. 相对蒸汽密度(g/mL,空气=1):未确定

4. 熔点(ºC):122 °C

5. 沸点(ºC,常压):未确定

6. 沸点(ºC,5.2kPa):未确定

7. 折射率:未确定

8. 闪点(ºC):未确定

9. 比旋光度(º):未确定

10. 自燃点或引燃温度(ºC):未确定

11. 蒸气压(kPa,25ºC):未确定

12. 饱和蒸气压(kPa,60ºC):未确定

13. 燃烧热(KJ/mol):未确定

14. 临界温度(ºC):未确定

15. 临界压力(KPa):未确定

16. 油水(辛醇/水)分配系数的对数值:未确定

17. 爆炸上限(%,V/V):未确定

18. 爆炸下限(%,V/V):未确定

19. 溶解性:未确定


Section I.Chemical Product and Company Identification
Chemical Name Etilefrine Hydrochloride
Portland OR
Benzenemethanol,
Synonym
α-[(ethylamino)methyl]-3-hydroxy-hydrochloride (9CI)
HOC6H4CH(OH)CH2NHCH2CH3•HCl
Chemical Formula
CAS Number943-17-9

Section II.Composition and Information on Ingredients
Chemical NameCAS Number Percent (%)TLV/PELToxicology Data
Etilefrine Hydrochloride943-17-9Min. Not available.Rat LD50 (intravenous) 5 mg/kg
98.0%(Tit.)Mouse LD50 (subcutaneous) 860
mg/kg
Rat LDLO (oral) 187 mg/kg

Section III. Hazards Identification
Harmful if ingested or inhaled. Minimize exposure to this material. Severe overexposure can result in injury or death.
Acute Health Effects
Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.
CARCINOGENIC EFFECTS : Not available.
Chronic Health Effects
MUTAGENIC EFFECTS : Not available.
TERATOGENIC EFFECTS : Not available.
DEVELOPMENTAL TOXICITY: Not available.
Repeated or prolonged exposure to this compound is not known to aggravate existing medical conditions.

Section IV.First Aid Measures
Eye ContactCheck for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15
minutes. Get medical attention.
Skin ContactIn case of contact, immediately flush skin with plenty of water. Remove contaminated clothing and shoes. Wash clothing
before reuse. Thoroughly clean shoes before reuse. Get medical attention.
If the victim is not breathing, perform mouth-to-mouth resuscitation. Loosen tight clothing such as a collar, tie, belt or
Inhalation
waistband. If breathing is difficult, oxygen can be administered. Seek medical attention if respiration problems do not
improve.
INDUCE VOMITING by sticking finger in throat. Lower the head so that the vomit will not reenter the mouth and throat.
Ingestion
Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth
resuscitation. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that the
toxic material was ingested; the absence of such signs, however, is not conclusive.

Section V.Fire and Explosion Data
Auto-IgnitionNot available.
FlammabilityMay be combustible at high temperature.
Flash PointsFlammable LimitsNot available.
Not available.
Combustion ProductsThese products are toxic carbon oxides (CO, CO2), nitrogen oxides (NO, NO2).
WARNING: Highly toxic HCl gas is produced during combustion.
Fire Hazards
Not available.
Explosion HazardsRisks of explosion of the product in presence of mechanical impact: Not available.
Risks of explosion of the product in presence of static discharge: Not available.
Fire Fighting Media
SMALL FIRE: Use DRY chemical powder.
and InstructionsLARGE FIRE: Use water spray, fog or foam. DO NOT use water jet.
Consult with local fire authorities before attempting large scale fire-fighting operations.
Continued on Next Page
Etilefrine Hydrochloride

Section VI.Accidental Release Measures
Spill CleanupHarmful Material.
Use a shovel to put the material into a convenient waste disposal container. Finish cleaning the spill by rinsing any
Instructions
contaminated surfaces with copious amounts of water. Consult federal, state, and/or local authorities for assistance on
disposal.

Section VII. Handling and Storage
Handling and StorageHARMFUL. Keep away from heat. Mechanical exhaust required. When not in use, tightly seal the container and store in
a dry, cool place. Avoid excessive heat and light. Do not breathe dust.
Information
Always store away from incompatible compounds such as oxidizing agents.

Section VIII. Exposure Controls/Personal Protection
Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
airborne contaminants below the exposure limit.
Personal ProtectionSplash goggles. Lab coat. Dust respirator. Boots. Gloves. Suggested protective clothing might not be sufficient; consult
a specialist BEFORE handling this product. Be sure to use a MSHA/NIOSH approved respirator or equivalent.
Exposure LimitsNot available.

Section IX. Physical and Chemical Properties
Physical state @ 20°CSolid. (White Crystalline powder.)SolubilityNot available.
Not available.
Specific Gravity
Molecular Weight217.69Partition CoefficientNot available.
Boiling PointNot available.Vapor PressureNot applicable.
Melting Point122°C (251.6°F)Vapor DensityNot available.
Not available.VolatilityNot available.
Refractive Index
Not available.
Critical TemperatureNot available.Odor
Not available.Not available.
ViscosityTaste

Section X.Stability and Reactivity Data

This material is stable if stored under proper conditions. (See Section VII for instructions)
Stability
Conditions of Instability
Avoid excessive heat and light.
Incompatibilities
Reactive with oxidizing agents.

Section XI. Toxicological Information
RTECS NumberDO5618000
Routes of ExposureEye Contact. Ingestion. Inhalation.
Rat LD50 (intravenous) 5 mg/kg
Toxicity Data
Mouse LD50 (subcutaneous) 860 mg/kg
Rat LDLO (oral) 187 mg/kg
CARCINOGENIC EFFECTS : Not available.
Chronic Toxic Effects
MUTAGENIC EFFECTS : Not available.
TERATOGENIC EFFECTS : Not available.
DEVELOPMENTAL TOXICITY: Not available.
Repeated or prolonged exposure to this compound is not known to aggravate existing medical conditions.
Acute Toxic EffectsHarmful if ingested or inhaled. Minimize exposure to this material. Severe overexposure can result in injury or death.
Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.
Continued on Next Page
Etilefrine Hydrochloride

Section XII.Ecological Information
EcotoxicityNot available.
Not available.
Environmental Fate

Section XIII. Disposal Considerations
Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material with a
Waste Disposal
combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all
federal, state and local regulations when disposing of the substance.

Section XIV. Transport Information
DOT ClassificationNot a DOT controlled material (United States).
Not applicable.
PIN Number
Proper Shipping Name
Not applicable.
Packing Group (PG)Not applicable.
DOT Pictograms

Section XV. Other Regulatory Information and Pictograms
TSCA Chemical InventoryThis product is NOT on the EPA Toxic Substances Control Act (TSCA) inventory. The following notices are required by 40
CFR 720.36 (C) for those products not on the inventory list:
(EPA)
(i) These products are supplied solely for use in research and development by or under the supervision of a technically
qualified individual as defined in 40 CFR 720.0 et sec.
(ii) The health risks of these products have not been fully determined. Any information that is or becomes available will be
supplied on an MSDS sheet.
WHMIS ClassificationNot available.
(Canada)
EINECS Number (EEC)Not available.
EEC Risk StatementsR20/21/22- Harmful by inhalation, in contact with skin and if swallowed.


SECTION 16 - ADDITIONAL INFORMATION
N/A

毒理学数据:

1、急性毒性:小鼠口经LD50:345mg/kg;大鼠口经LD50:187mg/kg

2、急性毒性:小鼠静脉LD50:11mg/kg;大鼠静脉LD50:3mg/kg

3、急性毒性:小鼠皮下LD50:860mg/kg;大鼠皮下LD50:>420mg/kg

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DO5618000
CHEMICAL NAME :
Benzyl alcohol, alpha-((ethylamino)methyl)-m-hydroxy-, hydrochloride
CAS REGISTRY NUMBER :
943-17-9
LAST UPDATED :
199806
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C10-H15-N-O2.Cl-H
MOLECULAR WEIGHT :
217.72
WISWESSER LINE NOTATION :
QR CYQ1M2 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
187 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,413,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>420 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,187,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,225,1995
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
345 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,413,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
860 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,115,1982
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
11 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,413,1979

符号 GHS06
GHS06
信号词 Danger
危害声明 H301-H319
警示性声明 Missing Phrase - N15.00950417-P305 + P351 + P338
危险品运输编码 UN 2811 6.1 / PGIII
RTECS号 DO5618000
海关编码 2922509090
上游产品  0

下游产品  1

海关编码 2922509090
中文概述 2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:AB. 最惠国关税:6.5%. 普通关税:30.0%
申报要素 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
监管条件 A.入境货物通关单 B.出境货物通关单
检验检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验
Summary 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%