26787-78-0

• 常用中文名：阿莫西林
• 常用英文名：Amoxicillin
• CAS号：26787-78-0
• 分子式：C₁₆H₁₉N₃O₅S
• 分子量：365.404
• 相关类别： 原料药 抗生素类药物 青霉素类药
• 发布时间：2018-02-05 08:00:00
• 更新时间：2024-01-01 19:45:49
• Amoxicillin是中谱的β内酰胺抗菌素。

名称

• 中文名: 阿莫西林
• 英文名: amoxicillin
• 中文别名: 阿莫林; (2S,5R,6R)-3,3-二甲基-6-[(R)-(-)-2-氨基-2-(4-羟基苯基)乙酰氨基]-7-氧代-4-硫杂-1-氮杂双环[3.2.0]庚烷-2-甲酸; 阿莫西林钠克拉维酸钾
• 英文别名: Intermox; Lamoxy; A-Gram; Novenzymin; Amoxin; Amoxtrex; AMOX; Amoxa; Imaxilin; Uro-clamoxyl; Imox; Rancil; Moxylin; Ampidroxyl; MOx; Excillin; Tolodina; [2S-[2a,5a,6b(S*)]]-6-[[Amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid; Protexillin; Samosillin; Amoxy; Bridopen; Ranmoxy; Grunamox; 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-; Jerramcil; Kamoxin; Amoxaren; Zamocillin; Damoxicil; Zamocilline; Larocilin; Cilamox; Amoxy-diolan; Rhamoxilina; Zerrsox; Amoxicillin; Limox; Agerpen; Pasetocin; 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(1E,2R)-2-amino-1-hydroxy-2-(4-hydroxyphenyl)ethylidene]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-; Gomcillin; Amoxal; Gemox; (2S,5R,6R)-6-{(E)-[(2R)-2-Amino-1-hydroxy-2-(4-hydroxyphenyl)ethylidene]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; Sigmopen; Amoxine; Comoxyl; Moxaline; Zimox; amoxil; Bioxidona; blp1410; Amoxi-Diolan; Eupen; Alphamox; Azillin; 6-[D(-)-a-Amino-p-hydroxyphenylacetamido]penicillanic Acid; Zamox; Amoxina; Amagesen Solutab; Amoxi-basan; Amoxidal; Amoxillat; Suramox PM; amolin; Amoxisol; Amoxicillin-ratiopharm; Simplamox; Draximox; Amoxihexal; [2S,5R,6R]-6-[[[2R]-Amino[4-hydroxyphenyl]acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid; Optium; Moxlin; Virgoxillin; Trimox; Mopen; EINECS 248-003-8; Clamox; a-Amino-p-hydroxybenzylpenicillin; Amoxibiotic; Meixil; Hipen; Galenamox; Moxilen; Amoxipenil; Farconcil; Rocillin; Amosine; Gimalxina; Ciblor; Zamoxil; Anemol; α-Amino-p-hydroxybenzylpenicillin; Bioxyllin; PENSYN; Triafamox; Moxarin; amoxi; Morgenxil; Amoran; Moxyvit; Grinsul; p-Hydroxyampicillin; Amophar; Amopen; Amodex; (2S,5R,6R)-6-{[(2R)-2-Amino-2-(4-hydroxyphenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; Moxypen; Reloxyl; MFCD00072029; Apo-Amoxi; Efpinex; Ikamoxil; Amoxi-wolff; Sil-A-mox; Audumic; Alfamox; Bimox; Fullcilina; Ospamox; Triamoxil; Teramoxyl; Matasedrin; Penbiosyn; Ronemox; Amoxivan; Fisamox; Moxcil; Amoxillin; Winmox; Amcill; Amoxapen; Amoxipen; Pamoxicillin; Amo-flamsian; Abdimox; Biomox; Novabritine; Himinomax; Pacetocin; Posmox; 6-(p-Hydroxy-α-aminophenylacetamido)penicillanic acid; Novamoxin; Yisulon; Ranoxyl; Sintopen; Isimoxin; Acimox; Amoxcillin; Samthongcillin; Bintamox; Velamox; Gramidil; clavulanate; Twicyl; Adbiotin; 6-(p-Hydroxy-a-aminophenylacetamido)penicillanic Acid; Majorpen; Saltermox; Sia-mox; Izoltil; Amoflux; Utimox; Flemoxine; Imoxil; Paradroxil; Foxolin; Hidramox; Pamocil; Specillin; Kentrocyllin; Senox; Actimoxi; Trilaxin; Superpeni; amoxycillin; (-)-6-[2-Amino-2-(p-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid; Bactamox; Medimox; Sawamezin; Dura AX; Maxcil; Apitart; Coamoxin; Hosboral; sumox

物化性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 701.8±70.0 °C at 760 mmHg
• 分子式: C₁₆H₁₉N₃O₅S
• 分子量: 365.404
• 闪点: 378.2±35.7 °C
• 精确质量: 365.104553
• PSA: 158.26000
• LogP: 0.92
• 外观性状: 固体
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.745
• 储存条件: 2-8°C
• 稳定性: Stable. Incompatible with strong oxidizing agents.

生物活性

• 描述: Amoxicillin是中谱的β内酰胺抗菌素。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 感染
• 参考文献:

  [1]. http://en.wikipedia.org/wiki/Amoxicillin

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : XH8300000 CHEMICAL NAME : 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((amino(4-hydroxyphenyl)acetyl) amino)-3,3-dimethyl-7-oxo- CAS REGISTRY NUMBER : 26787-78-0 LAST UPDATED : 199603 DATA ITEMS CITED : 12 MOLECULAR FORMULA : C16-H19-N3-O5-S MOLECULAR WEIGHT : 365.44 WISWESSER LINE NOTATION : T45 ANV ESTJ CMVYZR DQ& F1 F1 GVQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 40 mg/kg/4D TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea Gastrointestinal - other changes REFERENCE : LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 2,707,1978 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - child DOSE/DURATION : 682 mg/kg TOXIC EFFECTS : Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - urine volume decreased Kidney, Ureter, Bladder - hematuria REFERENCE : CPEDAM Clinical Pediatrics (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1962- Volume(issue)/page/year: 32,735,1993 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - child DOSE/DURATION : 300 mg/kg TOXIC EFFECTS : Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - hematuria Kidney, Ureter, Bladder - other changes in urine composition REFERENCE : CPEDAM Clinical Pediatrics (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1962- Volume(issue)/page/year: 32,735,1993 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >15 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,38,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2870 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,59,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >8 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,59,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >25 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,38,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3590 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,59,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >20 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,59,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intracerebral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >500 mg/kg TOXIC EFFECTS : Brain and Coverings - recordings from specific areas of CNS REFERENCE : CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968- Volume(issue)/page/year: 26,196,1980 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 3 gm/kg SEX/DURATION : female 7-12 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : AGSREJ Arab Gulf Journal of Scientific Research. (Arab Bureau of Education for the Gulf States, POB 3908, Riyadh, 11481, Saudi Arabia) V.7 No.2- 1989- Volume(issue)/page/year: 12,133,1994 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3562 No. of Facilities: 921 (estimated) No. of Industries: 3 No. of Occupations: 11 No. of Employees: 24519 (estimated) No. of Female Employees: 10563 (estimated)

安全

• 符号: GHS08
• 信号词: Danger
• 危害声明: H317-H334
• 警示性声明: P261-P280-P342 + P311
• 个人防护装备: dust mask type N95 (US);Eyeshields;Faceshields;Gloves
• 危害码 (欧洲): Xn:Harmful
• 风险声明 (欧洲): R42/43
• 安全声明 (欧洲): S22-S36/37
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 2
• RTECS号: XH8300000
• 海关编码: 2941109200

合成路线

上下游产品

上游产品  10
82095-48-5 68698-88-4 551-16-6 822-39-9
32462-30-9 3282-30-2 141-97-9 113210-35-8
73590-58-6 732216-08-9
下游产品  3
34642-77-8 73590-58-6 106-57-0

制备

【方法一】
由6-APA与N-（3-乙氧羰基-1-甲基乙烯基）对羟基苯甘氨酸钠盐经缩合而得。6-APA是生产各种半合成青霉素的重要原料。目前工业上大采用微生物产生的青霉素酰胺酶裂解天然青霉素（青霉素G或青霉素V）的办法来制取。

海关

海关编码	2941109200