中文名 |
酚磺乙胺
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英文名 |
2,5-Dihydroxybenzenesulfonic acid N-ethylethanamine (1:1)
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中文别名 |
二乙胺2,5-二羟基苯磺酸盐
异戊酰胺.异丙基乙酰胺
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英文别名 |
Diethylamine 2,5-Dihydroxybenzenesulfonate
1-Hydroxy-4-oxo-2,5-cyclohexadiene-1-sulfonic Acid Compd with Diethylamine
2,5-Dihydroxybenzenesulfonic acid - N-ethylethanamine (1:1)
MFCD00867499
Etamsylate
EINECS 220-090-7
Ethamsylate
2,5-Dihydroxybenzenesulfonic Acid Compd with N-Ethylethanamine
Benzenesulfonic acid, 2,5-dihydroxy-, compd. with N-ethylethanamine (1:1)
Benzenesulfonic acid,2,5-dihydroxy-,compd. with N-ethylethanamine
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描述 |
Ethamsylate是一种止血药物, 也抑制和前列腺素的生物合成和作用。
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相关类别 |
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沸点 |
496.4ºC at 760 mmHg
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熔点 |
127-131ºC
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分子式 |
C10H17NO5S
|
分子量 |
263.311
|
闪点 |
254ºC
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精确质量 |
263.082733
|
PSA |
115.24000
|
LogP |
2.43200
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外观性状 |
白色晶体或结晶粉末
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蒸汽压 |
1.13E-10mmHg at 25°C
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储存条件 |
2~8 ℃
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CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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DB6145000
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CHEMICAL NAME :
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Benzenesulfonic acid, 2,5-dihydroxy-, compd. with diethylamine
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CAS REGISTRY NUMBER :
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2624-44-4
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LAST UPDATED :
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199806
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DATA ITEMS CITED :
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13
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MOLECULAR FORMULA :
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C6-H6-O5-S.C4-H11-N
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MOLECULAR WEIGHT :
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263.34
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WISWESSER LINE NOTATION :
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WSQR BQ EQ &2M2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
-
Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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7500 mg/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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5250 mg/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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1350 mg/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intramuscular
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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>4 mg/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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8300 mg/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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29750 mg/kg
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TOXIC EFFECTS :
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Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - excitement
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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6040 mg/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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760 mg/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intramuscular
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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>4 gm/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Mammal - cat
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DOSE/DURATION :
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1 gm/kg
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TOXIC EFFECTS :
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Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - dyspnea
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TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
-
Oral
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SPECIES OBSERVED :
-
Rodent - guinea pig
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DOSE/DURATION :
-
3500 mg/kg
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TOXIC EFFECTS :
-
Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - excitement
MUTATION DATA
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TYPE OF TEST :
-
Sex chromosome loss and nondisjunction
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TEST SYSTEM :
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Mold - Aspergillus nidulans
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DOSE/DURATION :
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1 mg/L
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REFERENCE :
-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 26,159,1974
|
危害码 (欧洲) |
Xi
|
海关编码 |
2921199090
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【方法一】
由二乙胺用二氧化硫成盐后与对苯二醌加成而得。将二乙胺、乙醇和水加入反应锅内,冷至0℃,通入二氧化硫至反应液pH=3.5-4为止,反应温度控制在10℃以下,得二乙胺亚硫酸盐溶液。然后,于0-10℃缓缓加入对苯二醌。加毕,减压回收乙醇,冷却结晶,过滤。结晶加蒸馏水加热溶解,用活性炭脱色精制,即得酚磺乙胺成品。
海关编码 |
2922299090
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中文概述 |
2922299090. 其他氨基(萘酚、酚)及醚、酯〔包括它们的盐, 但含有一种以上含氧基的除外〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
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申报要素 |
品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
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Summary |
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
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