品牌现货直购
供应商:我要出现这里








查看所有供应商和价格请点击:

104-29-0生产厂家

104-29-0价格

104-29-0

104-29-0结构式
104-29-0结构式
  • 常用中文名:氯苯甘醚
  • 常用英文名:Chlorphenesin
  • CAS号:104-29-0
  • 分子式:C9H11ClO3
  • 分子量:202.635
  • 相关类别: 原料药 人工合成抗感染类药 抗真菌类药
  • 发布时间:2018-07-13 00:30:11
  • 更新时间:2024-01-04 15:20:59
  • Chlorphenesin 是一种可逆的抗原相关免疫抑制剂。Chlorphenesin 是一种抗菌和抗真菌剂,用于许多眼保健化妆品中。
  • 1、高含量高纯度,无杂质(对氯苯酚)残留。
    2、具有全球通用性,且应用广泛。欧洲自1996年就已允许作为防腐剂用于化妆品中,美国日本也允许使用。
    3、与大多数防腐剂相容(包括山梨酸钾、苯甲酸钠、MIT)。
    4、防腐剂,能抑制霉菌、酵母和细菌的生长,尤其对霉菌、酵母菌的抑制作用更强。
    5、不含任何有机或结合型甲醛,局部的皮肤或粘膜耐受性良好。
    6、不会增加脂肪的养护,而酚类防腐剂则时常会造成这种效应,同时也不会使蛋白质变性。
    7、属于有效低毒性的抗菌、抗真菌剂,同时也是有效的抗皮癬成分。
    8、作为一种防腐剂,它可以防止各种产品遇到粘度改变、PH变化、破乳问题、微生物生长、颜色变化和难闻气味产生等问题。
    9、耐热稳定性好,可溶于 65℃水、甘油或丙二醇。
    10、温和安全,推荐用量下无皮肤刺激性。

化源商城直购

中文名 氯苯甘醚
英文名 chlorphenesin
中文别名 3-对氯苯氧基-1,2-丙二醇
氯苯、一氯代苯
3-(4-氯苯氧基)-1,2-丙二醇
英文别名 Gecophen
Adermykon
Demykon
EINECS 203-192-6
3-(4-Chlorophenoxy)-1,2-propanediol
3-(4-chlorophenoxy)propane-1,2-diol
Chlorphenesinum
3-(p-Chlorophenoxy)propane-1,2-diol
Mycil
1,2-Propanediol, 3- (p-chlorophenoxy)-
p-chlorophenyl a-glyceryl ether
Chlorphenesine
Clorfenesina
MFCD00021990
Chlorphenesin
1,2-Propanediol, 3-(4-chlorophenoxy)-
Chlorophenesin
描述 Chlorphenesin 是一种可逆的抗原相关免疫抑制剂。Chlorphenesin 是一种抗菌和抗真菌剂,用于许多眼保健化妆品中。
相关类别
体外研究 氯苯那新(0.01,0.1,0.3%;30分钟暴露)显著降低人睑板腺上皮细胞(HMGECs)中Akt通路的活性,呈剂量依赖性[2]。氯苯那新(0.1,0.3%;24小时)诱导永生化HMGECs(IHMGECs)变圆、萎缩、粘附不良、脱落,并显著减少IHMGECs的数量[2]。
参考文献

[1]. H Y Whang, et al. Chlorphenesin: an antigen-associated immunosuppressant. Infect Immun. 1970 Jul;2(1):60-4.

[2]. Jingyi Wang, et al. Toxicity of the cosmetic preservatives parabens, phenoxyethanol and chlorphenesin on human meibomian gland epithelial cells. Exp Eye Res. 2020 Jul;196:108057.

密度 1.3±0.1 g/cm3
沸点 369.5±27.0 °C at 760 mmHg
熔点 77-79°C
分子式 C9H11ClO3
分子量 202.635
闪点 177.2±23.7 °C
精确质量 202.039673
PSA 49.69000
LogP 1.43
外观性状 白色至灰白色结晶粉末
蒸汽压 0.0±0.9 mmHg at 25°C
折射率 1.565
储存条件 储存于阴凉、通风的库房。远离火种、热源、水源。保持容器密封。应与氧化剂、还原剂分开存放,切忌混储。配备相应品种和数量的消防器 材。储区应备有合适的材料收容泄漏物。
稳定性

避免与氧化物接触。

计算化学

1.疏水参数计算参考值(XlogP):1.2

2.氢键供体数量:2

3.氢键受体数量:3

4.可旋转化学键数量:4

5.互变异构体数量:无

6.拓扑分子极性表面积49.7

7.重原子数量:13

8.表面电荷:0

9.复杂度:135

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:1

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

更多

1. 性状:白色晶体状粉末。

2. 密度(g/mL,20℃):未确定

3. 相对蒸汽密度(g/mL,空气=1):未确定

4. 熔点(ºC):77-79

5. 沸点(ºC,常压):未确定

6. 沸点(ºC, kPa):未确定

7. 折射率:未确定

8. 闪点(ºC):未确定

9. 比旋光度(º):未确定

10. 自燃点或引燃温度(ºC): 未确定

11. 蒸气压(mmHg,ºC):未确定

12. 饱和蒸气压(kPa, ºC):未确定

13. 燃烧热(KJ/mol):未确定

14. 临界温度(ºC):未确定

15. 临界压力(KPa):未确定

16. 油水(辛醇/水)分配系数的对数值:未确定

17. 爆炸上限(%,V/V):未确定

18. 爆炸下限(%,V/V):未确定

19. 溶解性:未确定

Material Safety Data Sheet

Section1. Identification of the substance
Chlorphenesin
Product Name:
Synonyms:3-(4-Chlorophenoxy)-1,2-Propanediol

Section2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.
H315:Causes skin irritation
H319:Causes serious eye irritation
H335:May cause respiratory irritation
P261:Avoid breathing dust/fume/gas/mist/vapours/spray
Wear protective gloves/protective clothing/eye protection/face protection
P280:
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present
and easy to do – continue rinsing
P304+P340:IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
P405:Store locked up

Section3. Composition/information on ingredients.
Chlorphenesin
Ingredient name:
CAS number:104-29-0

Section4. First aid measures
Immediately wash skin with copious amounts of water for at least 15 minutes while removing
Skin contact:
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.
Ingestion:

Section5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Storage:Store in closed vessels.

Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section9. Physical and chemical properties
Not specified
Appearance:
Boiling point:No data
Melting point:No data
Flash point:No data
Density:No data
Molecular formula:C9H11ClO3
Molecular weight:202.6

Section10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, hydrogen chloride.

Section11. Toxicological information
No data.

Section12. Ecological information
No data.

Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section14. Transportation information
Non-harzardous for air and ground transportation.

Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.


SECTION 16 - ADDITIONAL INFORMATION
N/A

毒理学数据:

急性毒性:小鼠皮下LD50:911mg/kg;

生态学数据:

通常对水没有危害。

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TY4260000
CHEMICAL NAME :
1,2-Propanediol, 3-(p-chlorophenoxy)-
CAS REGISTRY NUMBER :
104-29-0
BEILSTEIN REFERENCE NO. :
2210845
LAST UPDATED :
199709
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C9-H11-Cl-O3
MOLECULAR WEIGHT :
202.65
WISWESSER LINE NOTATION :
Q1YQ1OR DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
911 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - muscle weakness Lungs, Thorax, or Respiration - other changes
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 93,470,1948

危害码 (欧洲) Xn
风险声明 (欧洲) R20/21/22
安全声明 (欧洲) S26-S36
海关编码 2909499000
海关编码 2909499000
中文概述 2909499000 其他醚醇及其卤化、磺化、硝化或亚硝化衍生物. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:5.5% 普通关税:30.0%
申报要素 品名, 成分含量, 用途
Summary 2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%