179528-45-1

179528-45-1结构式

中文名	3-(4-碘苯基-2-疏基-(z)-2-丙酸
英文名	(Z)-3-(4-iodophenyl)-2-sulfanylprop-2-enoic acid
中文别名	非肽CALPAIN抑制剂(PD150606) (Z)-3-(4-碘苯基)-2-巯基丙烯酸 PD 150606,CALPAIN抑制剂
英文别名	3-(4-IODOPHENYL)-2-MERCAPTO-(Z)-2-PROPENOIC ACID (Z)-3-(4-iodophenyl)-2-mercaptoacrylic acid PD 150606, Calpain inhibitor 2-Propenoic acid, 3-(4-iodophenyl)-2-mercapto-, (2Z) PD150606;PD-150606;PD (2Z)-3-(4-Iodophenyl)-2-sulfanylacrylic acid (Z)-3-(4-IODOPHENYL)-2-SULFANYLPROP-2-ENOIC ACID (2Z)-3-(4-iodophenyl)-2-sulfanylprop-2-enoic acid PD150606 (PD PD-123319-d6 Bis(Trifluoroacetic Acid Salt) Salt Hydrate (Z)-3-(4-Iodophenyl)-2-mercapto-2-propenoic acid (2Z)-3-(4-iodophenyl)-2-mercapto-2-Propenoic acid PD150606, 10 mM in DMSO

描述	PD 150606是一个选择性的,能穿过细胞的非肽calpain抑制剂。
相关类别	信号通路 >> 代谢酶/蛋白酶 >> 蛋白酶体研究领域 >> 癌症
参考文献	[1]. Squier MK et al. Calpain and calpastatin regulate neutrophil apoptosis. J Cell Physiol. 1999 Mar;178(3):311-9. [2]. Waters SL et al. Calpains mediate calcium and chloride influx during the late phase of cell injury. J Pharmacol Exp Ther. 1997 Dec;283(3):1177-84. [3]. Wang KK et al. An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective. Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6687-92.