Lovastatin-d3

• 常用名: Lovastatin-d3
• 英文名: Lovastatin-d3
• CAS号: 1002345-93-8
• 分子量: 407.56
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₃₃D₃O₅
• 熔点: N/A
• 闪点: N/A

Lovastatin-d3用途

洛伐他汀-d3是氘标记的洛伐他汀。洛伐他汀是一种细胞通透性HMG-CoA还原酶抑制剂,用于降低胆固醇。

Lovastatin-d3名称

• 英文名: Lovastatin-d3

Lovastatin-d3生物活性

• 描述: 洛伐他汀-d3是氘标记的洛伐他汀。洛伐他汀是一种细胞通透性HMG-CoA还原酶抑制剂,用于降低胆固醇。
• 相关类别:
  研究领域 >> 癌症
  研究领域 >> 心血管疾病
  信号通路 >> 代谢酶/蛋白酶 >> HMG-CoA还原酶(HMGCR)
  信号通路 >> 细胞凋亡 >> Ferroptosis
  信号通路 >> 自噬 >> 自噬
• 体外研究: 氢、碳和其他元素的稳定重同位素已被纳入药物分子中,主要作为药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
• 参考文献:

  [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

  [2]. Alberts AW, et al. Discovery, biochemistry and biology of lovastatin. Am J Cardiol. 1988 Nov 11;62(15):10J-15J.

  [3]. Kah J, et al. Selective induction of apoptosis by HMG-CoA reductase inhibitors in hepatoma cells and dependence on p53 expression. Oncol Rep. 2012 Sep;28(3):1077-83.

  [4]. Frishman WH, et al. Lovastatin: an HMG-CoA reductase inhibitor for lowering cholesterol. Med Clin North Am. 1989 Mar;73(2):437-48.

  [5]. Tobert JA, et al. Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors. Nat Rev Drug Discov. 2003 Jul;2(7):517-26.

  [6]. Ifergan I, et al. Statins reduce human blood-brain barrier permeability and restrict leukocyte migration: relevance to multiple sclerosis. Ann Neurol. 2006 Jul;60(1):45-55.

Lovastatin-d3物理化学性质

• 分子式: C₂₄H₃₃D₃O₅
• 分子量: 407.56
• InChIKey: PCZOHLXUXFIOCF-VWOIVJJTSA-N
• SMILES: CCC(C)C(=O)OC1CC(C)C=C2C=CC(C)C(CCC3CC(O)CC(=O)O3)C21

Lovastatin-d3靶点实验

查看更多实验

实验名称：The drug is tested on Eggerthella lenta strain: ATCC25559 for biotransformation. The ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5303580

实验名称：Drug screen in LFS_MB_P medulloblastoma cells to determine synergistic drug combinati... 来源：25008 靶标：N/A External Id：DKFZ_drug_screen_chromothripsis_LFS_MB_P

实验名称：The drug is tested on Collinsella intestinalis strain: DSM13280 for biotransformation... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5303579

实验名称：The drug is tested on Bacteroides caccae strain: ATCC43185 for biotransformation. The... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5303582

实验名称：Drug screen in ICB984 medulloblastoma cells to determine synergistic drug combination... 来源：25008 靶标：N/A External Id：DKFZ_drug_screen_chromothripsis_ICB984_MB

实验名称：The drug is tested on Alistipes indistinctus strain: DSM22520 for biotransformation. ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5303581

实验名称：Drug screen in HDN33 neuroblastoma cells to determine synergistic drug combinations t... 来源：25008 靶标：N/A External Id：DKFZ_drug_screen_chromothripsis_HDN33

实验名称：The drug is tested on Bifidobacterium longum subsp. Infantis strain: CCUG52486 for bi... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5303576

实验名称：The drug is tested on Bifidobacterium breve strain: DSM20213 for biotransformation. T... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5303575

实验名称：The drug is tested on Collinsella aerofaciens strain: ATCC25986 for biotransformation... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5303578

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