盐酸普拉克索

• 常用名: 盐酸普拉克索
• 英文名: Pramipexole dihydrochloride
• CAS号: 104632-25-9
• 分子量: 284.249
• 密度: N/A
• 沸点: 378ºC at 760 mmHg
• 分子式: C₁₀H₁₉Cl₂N₃S
• 熔点: 288-290ºC
• 闪点: 182.4ºC

盐酸普拉克索用途

Pramipexole双盐酸盐是部分和完全的D2S,D2L,D3和D4受体激动剂, Ki分别为3.9,2.2,0.5和5.1 nM。

盐酸普拉克索名称

• 中文名: 盐酸普拉克索
• 英文名: pramipexole hydrochloride anhydrous
• 中文别名: S(-)-2-氨基-6-正丙氨基-4,5,6,7-四氢苯并噻唑二盐酸盐 | (S)-普拉克索二盐酸化物

盐酸普拉克索生物活性

• 描述: Pramipexole双盐酸盐是部分和完全的D2S,D2L,D3和D4受体激动剂, Ki分别为3.9,2.2,0.5和5.1 nM。
• 相关类别:
  信号通路 >> 自噬 >> 自噬
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体
  信号通路 >> 神经信号通路 >> 多巴胺受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Mierau J, Schneider FJ, Ensinger HA et al. Pramipexole binding and activation of cloned and expressed dopamine D2, D3 and D4 receptors. Eur J Pharmacol. 1995 Jun 23;290(1):29-36.

  [2]. El-Mallakh RS, Penagaluri P, Kantamneni A et al. Long-term use of pramipexole in bipolar depression: a naturalistic retrospective chart review. Psychiatr Q. 2010 Sep;81(3):207-13.

  [3]. Perez-Lloret S, Rey MV, Ratti L, Rascol O. Pramipexole for the treatment of early Parkinson's disease. Expert Rev Neurother. 2011 Jul;11(7):925-35.

  [4]. Hametner EM, Seppi K, Poewe W. Pramipexole extended release in Parkinson's disease. Expert Rev Neurother. 2011 Sep;11(9):1229-34.

  [5]. Hametner EM, Seppi K, Poewe W. Role and clinical utility of pramipexole extended release in the treatment of early Parkinson's disease. Clin Interv Aging. 2012;7:83-8.

盐酸普拉克索物理化学性质

• 沸点: 378ºC at 760 mmHg
• 熔点: 288-290ºC
• 分子式: C₁₀H₁₉Cl₂N₃S
• 分子量: 284.249
• 闪点: 182.4ºC
• 精确质量: 283.067688
• PSA: 79.18000
• LogP: 4.15830
• InChIKey: QMNWXHSYPXQFSK-KLXURFKVSA-N
• SMILES: CCCNC1CCc2nc(N)sc2C1.Cl.Cl
• 外观性状: 白色结晶粉末
• 蒸汽压: 6.49E-06mmHg at 25°C
• 储存条件: Desiccate at RT

盐酸普拉克索安全信息

• 危害码 (欧洲): Xi
• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2934999090

盐酸普拉克索海关

• 海关编码: 2934999090
• 中文概述: 2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

盐酸普拉克索靶点实验

查看更多实验

实验名称：Thermal Shift Assay. Domain start/stop: M626-G740 来源：ChEMBL 靶标：Peregrin External Id：CHEMBL4650107

实验名称：Thermal Shift Assay. Domain: start/stop: M1-L298 来源：ChEMBL 靶标：Cyclin-dependent kinase 2 External Id：CHEMBL5062802

实验名称：Thermal Shift Assay. Domain: start/stop: G861-E979 来源：ChEMBL 靶标：Transcription intermediary factor 1-alpha External Id：CHEMBL5069196

实验名称：Thermal Shift Assay. Domain: start/stop: P449-E759 来源：ChEMBL 靶标：Fibroblast growth factor receptor 3 External Id：CHEMBL5065480

实验名称：Thermal Shift Assay. Domain: start/stop: N44-E168 来源：ChEMBL 靶标：Bromodomain-containing protein 4 External Id：CHEMBL5061764

实验名称：Dicer-mediated maturation of pre-microRNA 来源：Center for Chemical Genomics, University of Michigan 靶标：N/A External Id：TargetID_659_CEMA

实验名称：Inhibitory concentration against [3H]- spiperone binding to Dopamine receptor at 10 m... 来源：ChEMBL 靶标：D(2) dopamine receptor External Id：CHEMBL675844

实验名称：Percent difference of DA utilization when compared to saline at a dose of 10 mg/kg 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL778983

实验名称：Thermal Shift Assay. Domain: start/stop: M26-R383 来源：ChEMBL 靶标：Glycogen synthase kinase-3 beta External Id：CHEMBL5065589

实验名称：Percent difference of L-DOPA accumulation when compared to saline at a dose of 10 mg/... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL778984

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盐酸普拉克索英文别名

• 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N-propyl-, (6S)-, hydrochloride (1:2)
• (6S)-4,5,6,7-Tetrahydro-N6-propyl-2,6-benzothiazolediamine Dihydrochloride
• (S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride
• Pramipexole hydrochloride
• Pramipexole dihydrochloride
• MFCD00876894
• (S)-Pramipexole Dihydrochloride
• (6S)-N-Propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine dihydrochloride
• (S)-N6-Propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine dihydrochloride
• Pramipexole (dihydrochloride)