4-[(1-氧代-7-苯基庚基)氨基]-(4R)-辛酸

• 常用名: 4-[(1-氧代-7-苯基庚基)氨基]-(4R)-辛酸
• 英文名: (4R)-4-[(7-Phenylheptanoyl)amino]octanoic acid
• CAS号: 1101136-50-8
• 分子量: 347.492
• 密度: 1.0±0.1 g/cm3
• 沸点: 567.8±43.0 °C at 760 mmHg
• 分子式: C₂₁H₃₃NO₃
• 熔点: N/A
• 闪点: 297.2±28.2 °C

4-[(1-氧代-7-苯基庚基)氨基]-(4R)-辛酸用途

CAY10590(GK115)是分泌型磷脂酶A2(sPLA2)的抑制剂,可用于慢性炎症性肾脏疾病的研究[1]。

4-[(1-氧代-7-苯基庚基)氨基]-(4R)-辛酸名称

• 中文名: 4-[(1-氧代-7-苯基庚基)氨基]-(4R)-辛酸
• 英文名: (R)-4-(7-phenylheptanamido)octanoic acid

4-[(1-氧代-7-苯基庚基)氨基]-(4R)-辛酸生物活性

• 描述: CAY10590(GK115)是分泌型磷脂酶A2(sPLA2)的抑制剂,可用于慢性炎症性肾脏疾病的研究[1]。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 磷脂
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 前列腺素受体
  研究领域 >> 炎症/免疫
• 靶点实验:

  sPLA2

• 体外研究: CAY10590(GK115)(0-10μM；24小时)抑制系膜细胞中IL-1β/forskolin刺激的PGE2的形成[1]。
• 参考文献:

  [1]. Vasilakaki S, et al. Small Peptides Able to Suppress Prostaglandin E₂ Generation in Renal Mesangial Cells. Molecules. 2018 Jan 13;23(1):158.

4-[(1-氧代-7-苯基庚基)氨基]-(4R)-辛酸物理化学性质

• 密度: 1.0±0.1 g/cm3
• 沸点: 567.8±43.0 °C at 760 mmHg
• 分子式: C₂₁H₃₃NO₃
• 分子量: 347.492
• 闪点: 297.2±28.2 °C
• 精确质量: 347.246033
• PSA: 66.40000
• LogP: 4.55
• InChIKey: ANTPELWBOPVWPH-LJQANCHMSA-N
• SMILES: CCCCC(CCC(=O)O)NC(=O)CCCCCCc1ccccc1
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.511

4-[(1-氧代-7-苯基庚基)氨基]-(4R)-辛酸靶点实验

查看更多实验

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实验名称：A screen for small molecules that modulate mitochondrial supercomplex formation 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1482

实验名称：Inhibition of secretory phospholipase A2 in rat renal mesangial cells assessed as sup... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3807561

实验名称：Inhibition of human group 6A cytosolic Ca(2+)-independent phospholipase A2 at 0.091 m... 来源：ChEMBL 靶标：85/88 kDa calcium-independent phospholipase A2 External Id：CHEMBL1018112

实验名称：Inhibition of human group 5 Ca2+-dependent secretory phospholipase A2 at 0.091 mole f... 来源：ChEMBL 靶标：Phospholipase A2 group V External Id：CHEMBL1018113

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

实验名称：Stabilization of p53 in human papillomavirus-positive cells 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Cellular tumor antigen p53 External Id：HMS1485

实验名称：Discovering small molecule activators of G protein-gated inwardly-rectifying potassiu... 来源：15621 靶标：G protein-activated inward rectifier potassium channel 2 External Id：VANDERBILT_HTS_GIRK2_MPD

实验名称：Inhibition of human group 4A cytosolic Ca2+-dependent phospholipase A2 at 0.091 mole ... 来源：ChEMBL 靶标：Cytosolic phospholipase A2 External Id：CHEMBL1018111

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4-[(1-氧代-7-苯基庚基)氨基]-(4R)-辛酸英文别名

• (4R)-4-[(7-Phenylheptanoyl)amino]octanoic acid