氯普噻吨

• 常用名: 氯普噻吨
• 英文名: Chlorprothixene
• CAS号: 113-59-7
• 分子量: 315.860
• 密度: 1.3±0.1 g/cm3
• 沸点: 435.0±45.0 °C at 760 mmHg
• 分子式: C₁₈H₁₈ClNS
• 熔点: 97-98°
• 闪点: 216.9±28.7 °C

氯普噻吨用途

Chlorprothixene对多巴胺和组胺受体有高度的亲和力,对D1,D2,D3,D5,H1,5-HT2,5-HT6和5-HT7的Ki分别为18 nM,2.96 nM,4.56 nM,9 nM,3.75 nM,9.4 nM,3 nM和5.6 nM。

氯普噻吨名称

• 中文名: 氯普噻吨
• 英文名: chlorprothixene
• 中文别名: (Z)-N,N-二甲基-3-(2-氯-9H-亚噻吨基)-1-丙胺 | 反式-2-氯-9-(3-二甲胺基亚丙基)硫杂蒽

氯普噻吨生物活性

• 描述: Chlorprothixene对多巴胺和组胺受体有高度的亲和力,对D1,D2,D3,D5,H1,5-HT2,5-HT6和5-HT7的Ki分别为18 nM,2.96 nM,4.56 nM,9 nM,3.75 nM,9.4 nM,3 nM和5.6 nM。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体
  信号通路 >> 神经信号通路 >> 多巴胺受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. von Coburg, Y., et al., Potential utility of histamine H3 receptor antagonist pharmacophore in antipsychotics. Bioorg Med Chem Lett, 2009. 19(2): p. 538-42.

  [2]. Roth, B.L., et al., Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J Pharmacol Exp Ther, 1994. 268(3): p. 1403-10.

  [3]. Becker, K.A., et al., Acid sphingomyelinase inhibitors normalize pulmonary ceramide and inflammation in cystic fibrosis. Am J Respir Cell Mol Biol, 2010. 42(6): p. 716-24.

氯普噻吨物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 435.0±45.0 °C at 760 mmHg
• 熔点: 97-98°
• 分子式: C₁₈H₁₈ClNS
• 分子量: 315.860
• 闪点: 216.9±28.7 °C
• 精确质量: 315.084839
• PSA: 28.54000
• LogP: 6.05
• InChIKey: WSPOMRSOLSGNFJ-AUWJEWJLSA-N
• SMILES: CN(C)CCC=C1c2ccccc2Sc2ccc(Cl)cc21
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.683
• 储存条件: -20°C
• 分子结构:

  1、 摩尔折射率：95.35

  2、 摩尔体积（cm³/mol）：251.4

  3、 等张比容（90.2K）：684.5

  4、 表面张力（dyne/cm）：54.8

  5、 极化率（10-24cm3）：37.80

• 更多:

  1.性状：淡黄色结晶性粉末。

  2. 熔点（ºC）：97-98

  3.溶解性：不溶于乙醇、乙醚、氯仿。

氯普噻吨毒性和生态

氯普噻吨安全信息

• 危害码 (欧洲): Xi
• 海关编码: 2932999099

氯普噻吨制备

邻氨基苯甲酸经重氮化、缩合、环合制得母核2-氯硫杂蒽酮。然后，母核与1-氯-3-二甲氨基丙烷加成得到2-氯-9-（3-二甲氨基丙基）-9-羟基硫杂蒽，经消除反应获得α,β-泰尔登，分离出α-泰尔登，将回收的β-泰尔登转化成α-泰尔登，合并精制得成品。

氯普噻吨海关

• 海关编码: 2932999099
• 中文概述: 2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

氯普噻吨靶点实验

查看更多实验

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

实验名称：Inhibition of Pdr5p-mediated rhodamine 6G transport in Saccharomyces cerevisiae MKPDR... 来源：ChEMBL 靶标：Pleiotropic ABC efflux transporter of multiple drugs External Id：CHEMBL1696307

实验名称：Apparent partition coefficient was measured as histamine releasing activity in rat ma... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL797214

实验名称：Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberc... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：GDH-TPI_INH_ABS_1536_1X%INH CSRUN

实验名称：qHTS for Inhibitors of TGF-b: Cytotox Counterscreen 来源：NCGC 靶标：N/A External Id：SMAD3201

实验名称：uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay 来源：Burnham Center for Chemical Genomics 靶标：cystic fibrosis transmembrane conductance regulator [Homo sapiens] External Id：SBCCG-A764-CF-PAF-Primary-Assay

实验名称：Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 exp... 来源：ChEMBL 靶标：Solute carrier family 22 member 1 External Id：CHEMBL993349

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ant... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_ANT_FLUO8_1536_1X%INH PRUN

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氯普噻吨英文别名

• Ro 4-0403
• Tarasan
• (Z)-chlorprothixene
• Truxaletten
• Chlorprothixene
• (3Z)-3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dimethylpropan-1-amine
• chloroprothixene
• CPX
• N 714C
• (Z)-2-Chloro-9-(ω-dimethylaminopropylidene)thioxanthene
• (Z)-2-Chloro-9-(3'-dimethylaminopropylidene)thioxanthene
• Paxyl
• Truxil
• (Z)-2-Chloro-N,N-dimethylthioxanthene-D9,g-propylamine
• (Z)-a-2-Chloro-10-(3-dimethylaminopropylidene)thiaxanthene
• Taractan
• EINECS 204-032-8
• Truxal
• (3Z)-3-(2-Chloro-9H-thioxanthen-9-ylidene)-N,N-dimethyl-1-propanamine
• mk184
• n714