VU0155069

• 常用名: VU0155069
• 英文名: VU0155069
• CAS号: 1130067-06-9
• 分子量: 462.97100
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₂₇ClN₄O₂
• 熔点: N/A
• 闪点: N/A

VU0155069用途

VU0155069 (CAY10593),化合物 69 是一种选择性磷脂酶 D1 (PLD1) 抑制剂,IC50 值为 46 nM。VU0155069 (CAY10593) 在 transwell 测定中强烈抑制几种癌细胞系的侵袭性迁移。

VU0155069名称

• 英文名: (S)-WAY 100135 dihydrochloride

VU0155069生物活性

• 描述: VU0155069 (CAY10593),化合物 69 是一种选择性磷脂酶 D1 (PLD1) 抑制剂,IC50 值为 46 nM。VU0155069 (CAY10593) 在 transwell 测定中强烈抑制几种癌细胞系的侵袭性迁移。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> 磷脂
• 靶点实验:

  PLD1:46 nM (IC50)

  PLD2:933 nM (IC50)

• 参考文献:

  [1]. Scott SA, et al. Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat Chem Biol. 2009 Feb;5(2):108-17.

  [2]. Lewis JA, et al. Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1916-20.

VU0155069物理化学性质

• 分子式: C₂₆H₂₇ClN₄O₂
• 分子量: 462.97100
• 精确质量: 462.18200
• PSA: 70.13000
• LogP: 4.92040
• InChIKey: DRIMIUYGTDAQOX-KRWDZBQOSA-N
• SMILES: CC(CN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)NC(=O)c1ccc2ccccc2c1
• 储存条件: -20°C，干燥，密封

VU0155069安全信息

• 危害码 (欧洲): Xi

VU0155069靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Human PLD2 (Hydrolases) 来源：IUPHAR-DB 靶标：PLD2 (Hydrolases) [Homo sapiens] External Id：1434_Human

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t... 来源：NCGC 靶标：N/A External Id：MCC011

实验名称：Primary qHTS for Identification of Calcium Integrin Binding Protein 1 (CIB1) Competit... 来源：NCGC External Id：CIB1-p1-p2

实验名称：Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screeni... 来源：NCGC 靶标：N/A External Id：CPF001

实验名称：Inhibition of PLD2 mediated cancer cell migration in mouse PMT cells at 20 uM by tran... 来源：ChEMBL 靶标：Phospholipase D2 External Id：CHEMBL1220771

实验名称：Inhibition of PLD1 mediated cancer cell migration in mouse 4T1 cells at 0.2 uM by tra... 来源：ChEMBL 靶标：Phospholipase D1 External Id：CHEMBL1220770

共60条，当前第1页，共6页

1

2

3

4

5