PMEDAP

• 常用名: PMEDAP
• 英文名: PMEDAP
• CAS号: 113852-41-8
• 分子量: 288.20
• 密度: 2.03g/cm3
• 沸点: 748.7ºC at 760mmHg
• 分子式: C₈H₁₃N₆O₄P
• 熔点: N/A
• 闪点: 406.6ºC

PMEDAP用途

PMEDAP是人类免疫缺陷病毒(HIV)复制的有效抑制剂。PMEDAP具有抗小鼠巨细胞病毒(MCMV)活性。PMEDAP是Moloney鼠肉瘤病毒(MSV)诱导的肿瘤形成和相关死亡率的非常有效的抑制剂[1][2]。

PMEDAP名称

• 英文名: 2-(2,6-diaminopurin-9-yl)ethoxymethylphosphonic acid

PMEDAP生物活性

• 描述: PMEDAP是人类免疫缺陷病毒(HIV)复制的有效抑制剂。PMEDAP具有抗小鼠巨细胞病毒(MCMV)活性。PMEDAP是Moloney鼠肉瘤病毒(MSV)诱导的肿瘤形成和相关死亡率的非常有效的抑制剂[1][2]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 抗感染 >> HIV
  研究领域 >> 感染
  信号通路 >> 抗感染 >> CMV
• 体内研究: PMEDAP(0.25-5 mg/kg；IP；每日；从MSV感染之日起,持续四天)可导致接种MSV的新生小鼠肿瘤形成和死亡率的剂量依赖性抑制[1]。动物模型：3周龄雄性NMRI小鼠[1]剂量：0.25mg/kg、1mg/kg、5mg/kg给药：IP；每日的从感染当天开始,再持续四天结果：显著延迟肿瘤出现,提高荷瘤小鼠的存活率。
• 参考文献:

  [1]. Neyts J, et al. Activity of the anti-HIV agent 9-(2-phosphonyl-methoxyethyl)-2,6-diaminopurine against cytomegalovirus in vitro and in vivo [published correction appears in Eur J Clin Microbiol Infect Dis 1993 Jul;12(7):following 477]. Eur J Clin Microbiol Infect Dis. 1993;12(6):437-446.

  [2]. Naesens L, et al. 9-(2-Phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP): a novel agent with anti-human immunodeficiency virus activity in vitro and potent anti-Moloney murine sarcoma virus activity in vivo. Eur J Clin Microbiol Infect Dis. 1989;8(12):1043-1047.

PMEDAP物理化学性质

• 密度: 2.03g/cm3
• 沸点: 748.7ºC at 760mmHg
• 分子式: C₈H₁₃N₆O₄P
• 分子量: 288.20
• 闪点: 406.6ºC
• 精确质量: 288.07400
• PSA: 172.94000
• InChIKey: XHXFQGAZAVKMFF-UHFFFAOYSA-N
• SMILES: Nc1nc(N)c2ncn(CCOCP(=O)(O)O)c2n1
• 蒸汽压: 1.51E-23mmHg at 25°C
• 折射率: 1.826
• 储存条件: 2-8°C，避光，干燥，密封

PMEDAP安全信息

• 危害码 (欧洲): Xi

PMEDAP靶点实验

查看更多实验

实验名称：Antiviral activity against HPMPA-resistant HCMV AD169 clone 2 mutant infected in HEL ... 来源：ChEMBL 靶标：Human betaherpesvirus 5 External Id：CHEMBL1013494

实验名称：Antiviral activity against acyclovir-resistant HCMV AD169 clone 1 infected in HEL cel... 来源：ChEMBL 靶标：Human betaherpesvirus 5 External Id：CHEMBL1013495

实验名称：Antiviral activity against cidofovir HCMV AD169 clone 5 infected in human HEL cells a... 来源：ChEMBL 靶标：Human betaherpesvirus 5 External Id：CHEMBL1013492

实验名称：Antiviral activity against PMEDAP-resistant HCMV AD169 clone 4 infected in HEL cells ... 来源：ChEMBL 靶标：Human betaherpesvirus 5 External Id：CHEMBL1013493

实验名称：Antiviral activity against foscarnet-resistant HCMV AD169 clone C infected in HEL cel... 来源：ChEMBL 靶标：Human betaherpesvirus 5 External Id：CHEMBL1013491

实验名称：Antiviral activity against wild type HCMV AD169 infected in HEL cells assessed as inh... 来源：ChEMBL 靶标：Human betaherpesvirus 5 External Id：CHEMBL1013496

实验名称：Antiviral activity against wild type HCMV Davis infected in HEL cells assessed as inh... 来源：ChEMBL 靶标：Human betaherpesvirus 5 External Id：CHEMBL1013497

实验名称：Selectivity index, ratio of CC50 for HEL299 cells to EC50 for Camelpox virus CML14 in... 来源：ChEMBL 靶标：N/A External Id：CHEMBL995358

实验名称：Cytotoxicity against human Daudi cell after 4 hrs by MTS assay 来源：ChEMBL 靶标：Daudi External Id：CHEMBL1284237

实验名称：Inhibitory activity against cytomegalovirus (CMV) AD 169 strain 来源：ChEMBL 靶标：Cytomegalovirus External Id：CHEMBL690156

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PMEDAP英文别名

• {[2-(2,6-diamino-9h-purin-9-yl)ethoxy]methyl}phosphonic acid
• N-(2-Phosphonomethoxyethyl)-2,6-diaminopurine
• 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine
• 9-(2-phosphonomethoxyethyl)-2,6-diaminopurine
• 2,6-diamino-9-[2-(phosphonomethoxy)ethyl]purine
• 5-(3-Hydroxy-2-phosphonomethoxypropyladenine)
• PME-DAP
• Phosphonic acid,((2-(2,6-diamino-9H-purin-9-yl)ethoxy)methyl)
• PMEDAP