Illudin S

• 常用名: Illudin S
• 英文名: Illudin S
• CAS号: 1149-99-1
• 分子量: 264.31700
• 密度: 1.34g/cm3
• 沸点: 509.6ºC at 760mmHg
• 分子式: C₁₅H₂₀O₄
• 熔点: N/A
• 闪点: 276.1ºC

Illudin S用途

Illudin S 是一种倍半萜烯毒素,具有强抗肿瘤和抗病毒活性。Illudin S 具有基因毒性活性。

Illudin S名称

• 中文名: 隐陡头菌素S
• 英文名: Illudin S

Illudin S生物活性

• 描述: Illudin S 是一种倍半萜烯毒素,具有强抗肿瘤和抗病毒活性。Illudin S 具有基因毒性活性。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  研究领域 >> 感染
  信号通路 >> 细胞周期/DNA损伤 >> DNA烷基化剂/交联剂
• 体外研究: Illudin S(0-0.26nm；24-72小时)对人成纤维细胞具有细胞毒性[2]。细胞活力测定[2]细胞系：人成纤维细胞浓度：0-0.26nm培养时间：24小时,72小时结果：细胞存活率降低。
• 参考文献:

  [1]. Hansruedi Glatt, et al. Sulfotransferase-independent genotoxicity of illudin S and its acylfulvene derivatives in bacterial and mammalian cells. Arch Toxicol . 2014 Jan;88(1):161-9.

  [2]. Nicolaas G J Jaspers, et al. Anti-tumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways. DNA Repair (Amst). 2002 Dec 5;1(12):1027-38.

  [3]. Illudin S, the sole antiviral compound in mature fruiting bodies of Omphalotus illudens

Illudin S物理化学性质

• 密度: 1.34g/cm3
• 沸点: 509.6ºC at 760mmHg
• 分子式: C₁₅H₂₀O₄
• 分子量: 264.31700
• 闪点: 276.1ºC
• 精确质量: 264.13600
• PSA: 77.76000
• LogP: 0.71630
• InChIKey: DDLLIYKVDWPHJI-RDBSUJKOSA-N
• SMILES: CC1=C2C(=CC(C)(CO)C2O)C(=O)C(C)(O)C12CC2
• 蒸汽压: 1.61E-12mmHg at 25°C
• 折射率: 1.619
• 分子结构:

  1、 摩尔折射率：69.22

  2、 摩尔体积（cm³/mol）：197.1

  3、 等张比容（90.2K）：549.3

  4、 表面张力（dyne/cm）：60.2

  5、 极化率（10-24cm3）：27.44

Illudin S毒性和生态

Illudin S靶点实验

查看更多实验

实验名称：In vivo antitumor activity against mouse P388 cells assessed as increase in life span... 来源：ChEMBL 靶标：P388 External Id：CHEMBL995634

实验名称：Cytotoxicity against human HL60 cells after 48 hrs by trypan blue exclusion assay 来源：ChEMBL 靶标：HL-60 External Id：CHEMBL1027499

实验名称：Cytotoxicity against african green monkey CV1 cells at 5 ug/disk by neutral red stain... 来源：ChEMBL 靶标：N/A External Id：CHEMBL983140

实验名称：Antiviral activity against HSV1 infected in african green monkey CV1 cells at 5 ug/di... 来源：ChEMBL 靶标：Human alphaherpesvirus 1 External Id：CHEMBL983139

实验名称：Cytotoxicity against african green monkey CV1 cells at 2.5 ug/disk by neutral red sta... 来源：ChEMBL 靶标：N/A External Id：CHEMBL983142

实验名称：Antiviral activity against HSV1 infected in african green monkey CV1 cells at 2.5 ug/... 来源：ChEMBL 靶标：Human alphaherpesvirus 1 External Id：CHEMBL983141

实验名称：Cytotoxicity against african green monkey CV1 cells at 10 ug/disk by neutral red stai... 来源：ChEMBL 靶标：N/A External Id：CHEMBL983138

实验名称：Antiviral activity against HSV1 infected in african green monkey CV1 cells at 10 ug/d... 来源：ChEMBL 靶标：Human alphaherpesvirus 1 External Id：CHEMBL983137

实验名称：Cytotoxicity against african green monkey CV1 cells at 0.25 ug/disk by neutral red st... 来源：ChEMBL 靶标：N/A External Id：CHEMBL983148

实验名称：Antiviral activity against HSV1 infected in african green monkey CV1 cells at 0.25 ug... 来源：ChEMBL 靶标：Human alphaherpesvirus 1 External Id：CHEMBL983147

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Illudin S英文别名

• Lampterol
• Illusin S