Mefenamic acid D4

• 常用名: Mefenamic acid D4
• 英文名: Mefenamic acid D4
• CAS号: 1216745-79-7
• 分子量: 245.310
• 密度: 1.2±0.0 g/cm3
• 沸点: 398.8±0.0 °C at 760 mmHg
• 分子式: C₁₅H₁₁D₄NO₂
• 熔点: N/A
• 闪点: 195.0±0.0 °C

Mefenamic acid D4用途

Mefenamic acid D4 是 Mefenamic acid 的氘代物。Mefenamic acid 是一种非甾体抗炎剂,为竞争性的 hCOX-1 和 hCOX-2 抑制剂,IC50 值分别为 40 nM 和 3 μM。

Mefenamic acid D4名称

• 英文名: 2-[(2,3-Dimethylphenyl)amino](2H4)benzoic acid

Mefenamic acid D4生物活性

• 描述: Mefenamic acid D4 是 Mefenamic acid 的氘代物。Mefenamic acid 是一种非甾体抗炎剂,为竞争性的 hCOX-1 和 hCOX-2 抑制剂,IC50 值分别为 40 nM 和 3 μM。
• 相关类别:
  研究领域 >> 炎症/免疫
  信号通路 >> 免疫及炎症 >> COX
• 靶点:

  hCOX-1:40 nM (IC50)

  hCOX-2:3 nM (IC50)

• 参考文献:

  [1]. Gierse JK, et al. Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem J. 1995 Jan 15;305 (Pt 2):479-84.

  [2]. Hashemipour MA, et al. In Vitro Cytotoxic Effects of Celecoxib, Mefenamic Acid, Aspirin and Indometacin on Several Cells Lines. J Dent (Shiraz). 2016 Sep;17(3):219-25.

Mefenamic acid D4物理化学性质

• 密度: 1.2±0.0 g/cm3
• 沸点: 398.8±0.0 °C at 760 mmHg
• 分子式: C₁₅H₁₁D₄NO₂
• 分子量: 245.310
• 闪点: 195.0±0.0 °C
• 精确质量: 245.135391
• LogP: 5.33
• 蒸汽压: 0.0±0.0 mmHg at 25°C
• 折射率: 1.639

Mefenamic acid D4英文别名

• 2-[(2,3-Dimethylphenyl)amino](2H4)benzoic acid
• Benzoic-2,3,4,5-d4 acid, 6-[(2,3-dimethylphenyl)amino]-