HA-155

• 常用名: HA-155
• 英文名: HA-155
• CAS号: 1229652-22-5
• 分子量: 463.29
• 密度: 1.4±0.1 g/cm3
• 沸点: 691.0±65.0 °C at 760 mmHg
• 分子式: C₂₄H₁₉BFNO₅S
• 熔点: N/A
• 闪点: 371.7±34.3 °C

HA-155用途

(E/Z)-HA155是一种有效的自毒毒素(ATX)I型抑制剂。HA155可用于研究癌症、纤维化疾病、炎症、疼痛和血管生成[1]。

HA-155名称

• 英文名: HA-155

HA-155生物活性

• 描述: (E/Z)-HA155是一种有效的自毒毒素(ATX)I型抑制剂。HA155可用于研究癌症、纤维化疾病、炎症、疼痛和血管生成[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> 磷酸二酯酶(PDE)
  研究领域 >> 炎症/免疫
  研究领域 >> 神经疾病
• 靶点实验:

  Autotaxin[1]

• 参考文献:

  [1]. Joncour A, et al. Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors [published correction appears in J Med Chem. 2018 May 10;61(9):4270]. J Med Chem. 2017;60(17):7371-7392.

HA-155物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 691.0±65.0 °C at 760 mmHg
• 分子式: C₂₄H₁₉BFNO₅S
• 分子量: 463.29
• 闪点: 371.7±34.3 °C
• 精确质量: 463.106110
• LogP: 5.25
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.683

HA-155靶点实验

查看更多实验

实验名称：Kinetic solubility of compound in simulated intestinal fluid at pH 6.6 by HPLC analys... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5347941

实验名称：Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells ass... 来源：ChEMBL 靶标：Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 External Id：CHEMBL1804763

实验名称：Kinetic solubility of compound in simulated gastric fluid at pH 1.7 by HPLC analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5347940

实验名称：Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells ass... 来源：ChEMBL 靶标：Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 External Id：CHEMBL1176956

实验名称：HTS to identify compounds that affect the blood-brain barrier permeability in vitro 来源：26908 靶标：N/A External Id：HTS97080

实验名称：Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells ass... 来源：ChEMBL 靶标：Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 External Id：CHEMBL1176955

实验名称：Inhibition of human recombinant ATX 来源：ChEMBL 靶标：Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 External Id：CHEMBL5232721

实验名称：Inhibition of human recombinant ATX using ABTS as substrate by absorbance based analy... 来源：ChEMBL 靶标：Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 External Id：CHEMBL5232720

实验名称：Cytotoxicity against wild type Fibroblast (unknown origin) assessed as redcution in c... 来源：ChEMBL 靶标：Fibroblast External Id：CHEMBL5347943

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HA-155英文别名

• {4-[(4-{(Z)-[3-(4-Fluorobenzyl)-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl}phenoxy)methyl]phenyl}boronic acid
• MFCD28016544
• HA-155
• HA-130