Talsaclidine

• 常用名: Talsaclidine
• 英文名: Talsaclidine
• CAS号: 147025-53-4
• 分子量: 165.23200
• 密度: 1.06g/cm3
• 沸点: 251.1ºC at 760mmHg
• 分子式: C₁₀H₁₅NO
• 熔点: N/A
• 闪点: 73.3ºC
• 符号: GHS05
• 信号词: Danger

Talsaclidine用途

Talsaclidine 是一种毒蕈碱激动剂,具有优先神经刺激特性。Talsaclidine 是 M1 亚型的完全激动剂,M2 和M3 亚型的部分激动剂。

Talsaclidine名称

• 英文名: (3R)-3-prop-2-ynoxy-1-azabicyclo[2.2.2]octane

Talsaclidine生物活性

• 描述: Talsaclidine 是一种毒蕈碱激动剂,具有优先神经刺激特性。Talsaclidine 是 M1 亚型的完全激动剂,M2 和M3 亚型的部分激动剂。
• 相关类别:
  信号通路 >> 神经信号通路 >> mAChR
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Ensinger HA, et al. WAL 2014--a muscarinic agonist with preferential neuron-stimulating properties. Life Sci. 1993;52(5-6):473-80.

  [2]. Wienrich M, et al. Pharmacodynamic profile of the M1 agonist talsaclidine in animals and man. Life Sci. 2001 Apr 27;68(22-23):2593-600.

  [3]. Walland A, et al. In vivo consequences of M1-receptor activation by talsaclidine. Life Sci. 1997;60(13-14):977-84.

  [4]. Walland A, et al. Compensation of muscarinic bronchial effects of talsaclidine by concomitant sympathetic activation in guinea pigs. Eur J Pharmacol. 1997 Jul 9;330(2-3):213-9.

Talsaclidine物理化学性质

• 密度: 1.06g/cm3
• 沸点: 251.1ºC at 760mmHg
• 分子式: C₁₀H₁₅NO
• 分子量: 165.23200
• 闪点: 73.3ºC
• 精确质量: 165.11500
• PSA: 12.47000
• LogP: 0.66830
• InChIKey: XVFJONKUSLSKSW-JTQLQIEISA-N
• SMILES: C#CCOC1CN2CCC1CC2
• 蒸汽压: 0.0208mmHg at 25°C
• 折射率: 1.525

Talsaclidine安全信息

• 符号: GHS05
• 信号词: Danger
• 危害声明: H318
• 警示性声明: P280-P305 + P351 + P338
• 个人防护装备: dust mask type N95 (US);Eyeshields;Gloves
• 危害码 (欧洲): Xi
• 风险声明 (欧洲): R41
• 安全声明 (欧洲): S26
• 危险品运输编码: NONH for all modes of transport

Talsaclidine靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Agonist activity at human muscarinic M4 receptor expressed in CHO cells after 30 mins... 来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M4 External Id：CHEMBL3618846

实验名称：Agonist activity at human muscarinic M4 receptor expressed in CHO cells after 30 mins... 来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M4 External Id：CHEMBL3618845

实验名称：Agonist activity at human muscarinic M3 receptor expressed in CHO cells after 30 mins... 来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M3 External Id：CHEMBL3618844

实验名称：Agonist activity at human muscarinic M3 receptor expressed in CHO cells after 30 mins... 来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M3 External Id：CHEMBL3618843

实验名称：Agonist activity at human muscarinic M5 receptor expressed in CHO cells after 30 mins... 来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M5 External Id：CHEMBL3618848

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

实验名称：Agonist activity at human muscarinic M5 receptor expressed in CHO cells after 30 mins... 来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M5 External Id：CHEMBL3618847

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t... 来源：NCGC 靶标：N/A External Id：MCC011

实验名称：Primary qHTS for Identification of Calcium Integrin Binding Protein 1 (CIB1) Competit... 来源：NCGC External Id：CIB1-p1-p2

共26条，当前第1页，共3页

1

2

3

Talsaclidine英文别名

• WAL 2014
• Talsaclidine