Maropitant

• 常用名: Maropitant
• 英文名: Maropitant
• CAS号: 147116-67-4
• 分子量: 468.67300
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₂H₄₀N₂O
• 熔点: N/A
• 闪点: N/A

Maropitant用途

Maropitant是神经激肽(NK1)受体拮抗剂。

Maropitant名称

• 中文名: Maropitant
• 英文名: (2S,3S)-2-benzhydryl-N-[(5-tert-butyl-2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine

Maropitant生物活性

• 描述: Maropitant是神经激肽(NK1)受体拮抗剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 神经激肽受体
  信号通路 >> 神经信号通路 >> 神经激肽受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Hay Kraus BL. Efficacy of maropitant in preventing vomiting in dogs premedicated with hydromorphone. Vet Anaesth Analg. 2013 Jan;40(1):28-34.

  [2]. Lesman SP, Boucher JF, Grover GS, et al. The pharmacokinetics of maropitant citrate dosed orally to dogs at 2 mg/kg and 8 mg/kg once daily for 14 days consecutive days. J Vet Pharmacol Ther. 2012 Nov 20.

  [3]. Alvillar BM, Boscan P, Mama KR, et al. Effect of epidural and intravenous use of the neurokinin-1 (NK-1) receptor antagonist maropitant on the sevoflurane minimum alveolar concentration (MAC) in dogs. Vet Anaesth Analg. 2012 Mar;39(2):201-5.

  [4]. Ramsey DS, Kincaid K, Watkins JA et al. Safety and efficacy of injectable and oral maropitant, a selective neurokinin 1 receptor antagonist, in a randomized clinical trial for treatment of vomiting in dogs. J Vet Pharmacol Ther. 2008 Dec;31(6):538-43. doi: 10.1111/j.1365-2885.2008.00992.x.

  [5]. Benchaoui HA, Cox SR, Schneider RP et al. The pharmacokinetics of maropitant, a novel neurokinin type-1 receptor antagonist, in dogs. J Vet Pharmacol Ther. 2007 Aug;30(4):336-44.

  [6]. Maropitant

Maropitant物理化学性质

• 分子式: C₃₂H₄₀N₂O
• 分子量: 468.67300
• 精确质量: 468.31400
• PSA: 24.50000
• LogP: 6.70600
• 储存条件: 2-8℃

Maropitant英文别名

• 4XE2T9H4DH
• UNII-4XE2T9H4DH
• Maropitant
• Maropitant Citrate Salt
• CS-1065