m-PEG3-CH2COOH结构式
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常用名 | m-PEG3-CH2COOH | 英文名 | m-PEG3-CH2COOH |
|---|---|---|---|---|
| CAS号 | 16024-60-5 | 分子量 | 222.23600 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C9H18O6 | 熔点 | N/A | |
| MSDS | N/A | 闪点 | N/A |
m-PEG3-CH2COOH用途
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m-PEG3-CH2COOH 是一种基于 PEG 的 PROTAC linker,用于 PROTAC 合成。 |
| 中文名 | 3,6,9,12-四氧杂十三烷酸 |
|---|---|
| 英文名 | 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]acetic acid |
| 英文别名 | 更多 |
| 描述 | m-PEG3-CH2COOH 是一种基于 PEG 的 PROTAC linker,用于 PROTAC 合成。 |
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| 相关类别 | |
| 靶点 |
PEGs |
| 体外研究 | PROTACs包含两种不同的配体,它们通过连接体连接；一种是E3泛素连接酶的配体,另一种是靶蛋白的配体。PROTACs利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白。 |
| 参考文献 |
| 分子式 | C9H18O6 |
|---|---|
| 分子量 | 222.23600 |
| 精确质量 | 222.11000 |
| PSA | 74.22000 |
| 储存条件 | 室温，干燥，密封 |
| 危害码 (欧洲) | Xi |
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m-PEG3-CH2COOH 16024-60-5 |
| 文献：ISIS PHARMACEUTICALS, INC.; BUCHARDT, Dorte; NIELSEN, Peter Eigil; EGHOLM, Michael Patent: EP804456 B1, 2002 ; |
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~82%
m-PEG3-CH2COOH 16024-60-5 |
| 文献：Zech, Oliver; Kellermeier, Matthias; Thomaier, Stefan; Maurer, Eva; Klein, Regina; Schreiner, Christian; Kunz, Werner Chemistry - A European Journal, 2009 , vol. 15, # 6 p. 1341 - 1345 |
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~30%
m-PEG3-CH2COOH 16024-60-5 |
| 文献：Rerat, Vincent; Dive, Georges; Cordi, Alex A.; Tucker, Gordon C.; Bareille, Reine; Amedee, Joelle; Bordenave, Laurence; Marchand-Brynaert, Jacqueline Journal of Medicinal Chemistry, 2009 , vol. 52, # 22 p. 7029 - 7043 |
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~96%
m-PEG3-CH2COOH 16024-60-5 |
| 文献：Simeone, Luca; Mangiapia, Gaetano; Vitiello, Giuseppe; Irace, Carlo; Colonna, Alfredo; Ortona, Ornella; Montesarchio, Daniela; Paduano, Luigi Bioconjugate Chemistry, 2012 , vol. 23, # 4 p. 758 - 770 Title/Abstract Full Text View citing articles Show Details Simeone, Luca; Mangiapia, Gaetano; Irace, Carlo; Di Pascale, Antonio; Colonna, Alfredo; Ortona, Ornella; De Napoli, Lorenzo; Montesarchio, Daniela; Paduano, Luigi Molecular BioSystems, 2011 , vol. 7, # 11 p. 3075 - 3086 |
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~96%
m-PEG3-CH2COOH 16024-60-5 |
| 文献：Haines, Alan H.; Karntiang, Pipat Carbohydrate Research, 1980 , vol. 78, p. 205 - 211 |
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m-PEG3-CH2COOH 16024-60-5 |
| 文献：Heidkamp, Katharina; Aytemir, Memet; Vorlop, Klaus-Dieter; Pruesse, Ulf Catalysis Science and Technology, 2013 , vol. 3, # 11 p. 2984 - 2992 |
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m-PEG3-CH2COOH 16024-60-5 |
| 文献：Simeone, Luca; Mangiapia, Gaetano; Vitiello, Giuseppe; Irace, Carlo; Colonna, Alfredo; Ortona, Ornella; Montesarchio, Daniela; Paduano, Luigi Bioconjugate Chemistry, 2012 , vol. 23, # 4 p. 758 - 770 Title/Abstract Full Text View citing articles Show Details Simeone, Luca; Mangiapia, Gaetano; Irace, Carlo; Di Pascale, Antonio; Colonna, Alfredo; Ortona, Ornella; De Napoli, Lorenzo; Montesarchio, Daniela; Paduano, Luigi Molecular BioSystems, 2011 , vol. 7, # 11 p. 3075 - 3086 |
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m-PEG3-CH2COOH 16024-60-5 |
| 文献：Hu, Wei; Yan, Qifan; Zhao, Dahui Chemistry - A European Journal, 2011 , vol. 17, # 25 p. 7087 - 7094 |
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m-PEG3-CH2COOH 16024-60-5 |
| 文献：Tuchscherer; Schaarschmidt; Schulze; Hietschold; Lang Dalton Transactions, 2012 , vol. 41, # 9 p. 2738 - 2746 |
| (monomethoxy)triethylene glycol acetic acid |
| 2-(2-(2-methoxyethoxy)-ethoxy)-ethoxy-acetic acid |
| 3,6,9,12-tetraoxatridecanoic acid |
| CH3O-TEG acetic acid |
| 2,5,8,11-Tetraoxatridecan-13-oic acid |
