Leelamine hydrochloride

• 常用名: Leelamine hydrochloride
• 英文名: Leelamine hydrochloride
• CAS号: 16496-99-4
• 分子量: 321.928
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₃₂ClN
• 熔点: N/A
• 闪点: N/A

Leelamine hydrochloride用途

Leelamine hydrochloride 是一种从松树皮中提取的三环二萜分子。Leelamine hydrochloride 是一种大麻素 1 型 (CB1) 激动剂,也是前列腺癌细胞中 SREBP1 调节的脂肪酸/脂质合成的抑制剂,不受雄激素受体状态的影响。Leelamine hydrochloride 抑制调节脂肪酸合成的雄激素受体 (androgen receptor) 的转录活性。

Leelamine hydrochloride名称

• 中文名: 脱氢松香胺盐酸盐
• 英文名: [(1R,4aS,10aR)-1,4a-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthren-1-yl]methanamine,hydrochloride

Leelamine hydrochloride生物活性

• 描述: Leelamine hydrochloride 是一种从松树皮中提取的三环二萜分子。Leelamine hydrochloride 是一种大麻素 1 型 (CB1) 激动剂,也是前列腺癌细胞中 SREBP1 调节的脂肪酸/脂质合成的抑制剂,不受雄激素受体状态的影响。Leelamine hydrochloride 抑制调节脂肪酸合成的雄激素受体 (androgen receptor) 的转录活性。
• 相关类别:
  研究领域 >> 癌症
  研究领域 >> 内分泌
  信号通路 >> 代谢酶/蛋白酶 >> 脂肪酸合成酶(FAS)
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 大麻素受体
  信号通路 >> 其他 >> 雄激素受体
• 靶点实验:

  CB1

• 参考文献:

  [1]. Kuzu OF, et al. Leelamine mediates cancer cell death through inhibition of intracellular cholesterol transport. Mol Cancer Ther. 2014 Jul;13(7):1690-703.

  [2]. A.O. Ibegbu, et al. Therapeutic Potentials and uses of Cannabinoid Agonists in Health and Disease Conditions. British Journal of Pharmacology and Toxicology 3(2): 76-88, 2012

  [3]. Singh KB, et al. Leelamine is a Novel Lipogenesis Inhibitor in Prostate Cancer Cells In Vitro and In Vivo. Mol Cancer Ther. 2019 Aug 8.

Leelamine hydrochloride物理化学性质

• 分子式: C₂₀H₃₂ClN
• 分子量: 321.928
• 精确质量: 321.222321
• PSA: 26.02000
• LogP: 6.28130
• InChIKey: CVPQLGCAWUAYPF-WFBUOHSLSA-N
• SMILES: CC(C)c1ccc2c(c1)CCC1C(C)(CN)CCCC21C.Cl
• 储存条件: -20°C，干燥，密封

Leelamine hydrochloride安全信息

• 危害码 (欧洲): Xi

Leelamine hydrochloride靶点实验

查看更多实验

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：High Throughput Screening for Foot and Mouth Disease Virus Antivirals 来源：NCGC 靶标：N/A External Id：StopGo1

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Tocris HTS for Inhibitors of Aerobactin Synthetase lucA 来源：23265 External Id：IucA Pilot Assay Tocris Library

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Leelamine hydrochloride英文别名

• Abieta-8(14),9(11),12-trien-18-amine hydrochloride (1:1)
• 1-Phenanthrenemethanamine, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-, (1R,4aS,10aR)-, hydrochloride (1:1)
• 13-Isopropyl-podocarpa-8,11,13-trien-15-amine Hydrochloride
• (1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1,4a-dimethyl-7-(1-methylethyl-1-phenanthrenemethanamine) Hydrochloride
• Dehydroabiethylamine Hydrochloride
• Leelamine Hydrochloride