短叶老鹤草素A

• 常用名: 短叶老鹤草素A
• 英文名: Brevilin A
• CAS号: 16503-32-5
• 分子量: 346.417
• 密度: 1.2±0.1 g/cm3
• 沸点: 494.0±45.0 °C at 760 mmHg
• 分子式: C₂₀H₂₆O₅
• 熔点: N/A
• 闪点: 216.0±28.8 °C

短叶老鹤草素A用途

Brevilin A 是一种从 Centipeda minima 中分离的倍半萜内酯,具有抗癌活性。Brevilin A 是一种选择性的 JAK-STAT 信号通路抑制剂,通过减弱 JAK 信号和 阻塞 STAT3 信号起作用。Brevilin A 通过线粒体途径和 PI3K/AKT/mTOR 失活诱导结肠腺癌细胞 CT26 的凋亡和自噬。

短叶老鹤草素A名称

• 中文名: 短叶老鹤草素 A
• 英文名: Brevilin A

短叶老鹤草素A生物活性

• 描述: Brevilin A 是一种从 Centipeda minima 中分离的倍半萜内酯,具有抗癌活性。Brevilin A 是一种选择性的 JAK-STAT 信号通路抑制剂,通过减弱 JAK 信号和 阻塞 STAT3 信号起作用。Brevilin A 通过线粒体途径和 PI3K/AKT/mTOR 失活诱导结肠腺癌细胞 CT26 的凋亡和自噬。
• 相关类别:
  信号通路 >> 干细胞及 Wnt 通路 >> STAT
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  信号通路 >> JAK/STAT信号通路 >> JAK
  信号通路 >> 表观遗传学 >> JAK
  信号通路 >> 干细胞及 Wnt 通路 >> JAK
  信号通路 >> JAK/STAT信号通路 >> STAT
  信号通路 >> 自噬 >> 自噬
• 靶点实验:

  IC50: 10.6 µM (STAT3 signaling)[1]

• 参考文献:

  [1]. Chen X, et al. Brevilin A, a novel natural product, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells. PLoS One. 2013 May 21;8(5):e63697.

  [2]. You P, et al. Brevilin A induces apoptosis and autophagy of colon adenocarcinoma cell CT26 via mitochondrial pathway and PI3K/AKT/mTOR inactivation. Biomed Pharmacother. 2018 Feb;98:619-625.

短叶老鹤草素A物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 494.0±45.0 °C at 760 mmHg
• 分子式: C₂₀H₂₆O₅
• 分子量: 346.417
• 闪点: 216.0±28.8 °C
• 精确质量: 346.178009
• PSA: 69.67000
• LogP: 2.98
• InChIKey: KUPPZVXLWANEJJ-UXPPPGSFSA-N
• SMILES: CC=C(C)C(=O)OC1C2C(CC(C)C3C=CC(=O)C31C)OC(=O)C2C
• 外观性状: 粉末
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.535
• 储存条件: 2-8℃，干燥，密闭

短叶老鹤草素A安全信息

• 危害码 (欧洲): Xi

短叶老鹤草素A靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Inhibition of STAT3 in human LX2 cells assessed as reduction in TGF-1beta-induced STA... 来源：ChEMBL 靶标：Signal transducer and activator of transcription 3 External Id：CHEMBL4818129

实验名称：Inhibition of STAT3 in human LX2 cells assessed as reduction in TGF-1beta-induced CTG... 来源：ChEMBL 靶标：Signal transducer and activator of transcription 3 External Id：CHEMBL4818130

实验名称：Anti-fibrotic activity against human LX2 cells assessed as reduction in TGF-1beta-ind... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4818127

实验名称：Anti-fibrotic activity against human LX2 cells assessed as reduction in TGF-1beta-ind... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4818128

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

实验名称：Anticancer activity against human nasopharyngeal carcinoma cells measured upto 72 hrs... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4818131

实验名称：Antiviral activity against influenza A virus infected in MDCK cells assessed as reduc... 来源：ChEMBL 靶标：Influenza A virus External Id：CHEMBL4818132

实验名称：Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubat... 来源：ChEMBL 靶标：HeLa External Id：CHEMBL4815370

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t... 来源：NCGC 靶标：N/A External Id：MCC011

共30条，当前第1页，共3页

1

2

3

短叶老鹤草素A英文别名

• (3S,3aR,4S,4aR,7aR,8R,9aR)-3,4a,8-Trimethyl-2,5-dioxo-2,3,3a,4,4a,5,7a,8,9,9a-decahydroazuleno[6,5-b]furan-4-yl (2Z)-2-methyl-2-butenoate